The Relationship Between Arterial Stiffness and Nonalcoholic Fatty Liver Disease

Lee, Yong Jae; Shim, Jae Yong; Moon, Byoung-San; Shin, Youn Ho; Jung, Dong-Hyuk; Lee, Jung Hyun; Lee, Hye Ree

doi:10.1007/s10620-011-1819-3

Cited by 71 publications

(56 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies have shown that age and body mass index (BMI) are independent risk factors for the progression of arterial stiffness (Choi et al, 2013;Pal and Radavelli-Bagatini, 2013). Two Korean studies reported an independent association between baPWV and NAFLD in general subjects including the elderly (Kim et al, 2012;Lee et al, 2012). Considering that the incidence of NAFLD decreases with age (Lonardo et al, 2006) and increases with BMI (Vernon et al, 2011), general subjects may not be representative of the young and middle-aged population which are non-obese, non-hypertensive, and non-diabetic, and thus may not be useful for suggesting the direct association between NAFLD and arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Zhao

Song

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Background and objective: Non-alcoholic fatty liver disease (NAFLD) is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods: A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged (20-65 years) subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results: The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls ((1321±158) cm/s vs. (1244±154) cm/s; P<0.001). The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group (29.3% vs. 16.9%; P<0.001), and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness (both P for trend <0.001). Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions: Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Zhao

Song

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

show abstract

“…Given the different methods used to diagnose NAFLD and different populations chosen to perform studies, results are inconsistent. [5][6][7][8][9][10][11][12][13] In some relatively small samples from the community population, ultrasonographically diagnosed NAFLD has been found to be independently associated with carotid atherosclerosis and arterial stiffness. 6,7 Biopsy-proven NAFLD patients had remarkably greater carotid intimamedia thickness (CIMT) compared with that of age-, sex-, and body mass index (BMI)-matched healthy subjects in a case-control study.…”

mentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Huang

et al. 2012

ATVB

108

View full text Add to dashboard Cite

Objective-To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Methods and Results-A total of 8632 participants aged ≥40 years from Jiading district, Shanghai, were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30.0% in the total population, with 30.3% in men and 29.9% in women, respectively. Subjects with NAFLD had remarkably higher CIMT and ba-PWV compared with those without NAFLD (0.594±0.105 mm versus 0.578±0.109 mm, P<0.0001; 1665±424 cm/s versus 1558±430 cm/s, P<0.0001). Subjects with both NAFLD and metabolic syndrome had significantly higher CIMT and ba-PWV compared with those with neither or either of these 2 diseases after adjustment for age and sex (all P<0.05). Logistic regressions also revealed that NAFLD conferred 35% and 30% increased odds ratios of elevated CIMT and ba-PWV, independent of conventional risk factors and the presence of metabolic syndrome. Key Words: atherosclerosis ◼ brachial-ankle pulse wave velocity ◼ carotid intima-media thickness ◼ metabolic syndrome ◼ nonalcoholic fatty liver disease Conclusion-NAFLD

show abstract

“…Blood viscosity was higher in patients with NAFLD and was independently associated with AWS, even after adjusting for other risk factors. NA-FLD connection with AWS increase was presented in the study of Lee et al (2012). An independent association between PVPW and NAFLD, independently of other cardiovascular risk factors, was found with the help of multivariate regression analysis [116].…”

Section: Arterial Stiffnessmentioning

confidence: 96%

“…In addition, PVPW does not increase in the early stages of atherosclerosis and increases with the development of atherosclerotic plaques, mainly due to calcification of the arterial wall [31]. The increase in AWS in NAFLD was found [115][116][117]. However, the pathogenetic mechanisms of AWS formation in patients with NAFLD are completely unclear.…”

Section: Arterial Stiffnessmentioning

confidence: 99%

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Kuzmіnova

Gribenyuk

Osovska

et al. 2016

Arterial Hypertension

View full text Add to dashboard Cite

The combination of hypertension, obesity and non-alcoholic fatty liver disease occurs in medical practice very often. A number of studies have shown that non-alcoholic fatty liver disease increases the risk of cardiovascular disease independently of other predictors and manifestations of the metabolic syndrome. Current issues of research and identification of common pathogenic relationships of obesity, hypertension, and liver steatosis are investigated in the article. According to the analysed literature, it is indicated that insulin resistance and compensatory hyperinsulinaemia are considered as one of the key factors in the development of this comorbidity. The processes of chronic inflammation are increasing with the growth of adipose tissue volume. Some researchers believe that non-specific systemic inflammation combines arterial hypertension, increased body weight (especially abdominal obesity), steatosis, dyslipidaemia, atherogenesis and arteriosclerosis into a single syndrome. The role of non-alcoholic fatty liver disease in the growth of the thickness of the intima-media complex was studied. It is known that adipose tissue functions as an endocrine organ, expresses genes encoding bioactive substances, and secretes certain cytokines. A strong link between dysfunction of adipose tissue in patients with non-alcoholic fatty liver disease and in such conditions as metabolic syndrome and cardiovascular disease was demonstrated. The dysfunction of the endothelium is also advisable to consider as the connecting link between liver disease, obesity and hypertension. Despite some understanding of common pathogenic mechanisms for the development of non-alcoholic fatty liver disease and hypertension, this comorbid pathology remains the subject of much debate and a variety of studies. key words: arterial hypertension, obesity, non-alcoholic fatty liver disease, insulin resistance, dyslipidaemia, non-specific systemic inflammation, endothelial dysfunction, atherogenesis.

show abstract

The Relationship Between Arterial Stiffness and Nonalcoholic Fatty Liver Disease

Abstract: Arterial stiffness was independently associated with the prevalence risk for NAFLD regardless of classical CVD risk factors.

Cited by 71 publications

References 31 publications

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Contact Info

Product

Resources

About