The relationship between attention deficit hyperactivity disorder and reelin gene polymorphisms in Turkish population

Abstract

PURPOSE: Although attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen psychiatric disorders in childhood, its etiology and pathophysiology are not fully elucidated. The aim of the present study was to investigate the association between ADHD and RELN gene in Turkish children. METHOD: DNA samples were harvested from 102 patients with ADHD and 94 healthy controls. Three single-nucleotide polymorphisms of reelin gene (rs1270519, rs362691, and rs734147) were genotyped using real-time polymerase chain reaction. RESULTS: A significant difference was detected between ADHD and control groups regarding rs1270519 polymorphism while no significant difference was detected between the groups regarding reelin rs362691 and rs734147 polymorphisms. CONCLUSION: It was found that reelin rs12705169 gene polymorphism could play a role in ADHD etiology, indicating the need for further studies to investigate the relationship between ADHD and reelin gene polymorphism.

Genetic Variants and Haplotypes of Tryptophan Hydroxylase 2 and Reelin Genes May Be Linked with Attention Deficit Hyperactivity Disorder in Egyptian Children

“…Despite the fact that potential relationships between RELN gene abnormalities and several psychiatric disorders have been examined, only the link between ADHD and the RELN gene has been reported thus far. Kwon et al 17 26 observed a nonsignificant correlation between RELN rs362691 and RELN rs734147, whereas there was a significant correlation regarding RELN rs12705169 and the occurrence of ADHD among Turkish children.…”

“…The high ranking of comorbidities and family aggregation in both conditions led the authors to hypothesize that comparable inherent aspects can be concerned with ADHD. 26 In autistic children, Reelin was reported as a likely genetic risk factor. Wang and colleagues postulated that RELN rs36269 could pose a greater risk of autism disorder than RELN rs736707 or GGC genetic repetition.…”

“…Kwon et al evaluated the frequencies of eight RELN gene single nucleotide polymorphisms ( RELN rs736707, RELN rs2229864, RELN rs362746, RELN rs362726, RELN rs362691, RELN rs1062831, RELN rs607755, and RELN rs2072403) in Korean children with ADHD, and they suggested that RELN rs736707 was the only SNP that is significantly associated with ADHD in Korean children. Kara et al observed a nonsignificant correlation between RELN rs362691 and RELN rs734147, whereas there was a significant correlation regarding RELN rs12705169 and the occurrence of ADHD among Turkish children.…”

“…The author further argued that these shared contributing factors provide an explanation for why these illnesses are found consistently in the same family and co-occur in the same persons. The high ranking of comorbidities and family aggregation in both conditions led the authors to hypothesize that comparable inherent aspects can be concerned with ADHD …”

“…The findings in the current study indicate that that TPH2 rs11179027 (G/C) and RELN rs736707­(A/G) gene polymorphisms may be affected by sex, which is not the case for TPH2 rs1843809 (G/C) and RELN rs362691 (G/C) gene polymorphisms. Kara et al reported that RELN rs362691 (G/C) gene polymorphism was unaffected by sex while the neurological subtype of ADHD might affect RELN rs736707 (A/G) gene polymorphism and it had no influence on other studied SNPs.…”