2012
DOI: 10.1016/j.clinph.2012.01.028
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The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1G93A mice

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Cited by 36 publications
(47 citation statements)
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References 62 publications
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“…In a study in SOD1 mutant mice, it has been shown that pNfH levels increase as disease progresses up to day 120 [31]. This study did not extend to the end stage of disease (150-180 days) when, as we have shown, few axons remain [32], and we suggest that it is possible that the levels would decline if mice were samples at this later stage.…”
Section: Discussioncontrasting
confidence: 60%
“…In a study in SOD1 mutant mice, it has been shown that pNfH levels increase as disease progresses up to day 120 [31]. This study did not extend to the end stage of disease (150-180 days) when, as we have shown, few axons remain [32], and we suggest that it is possible that the levels would decline if mice were samples at this later stage.…”
Section: Discussioncontrasting
confidence: 60%
“…Motor neurons were identified after staining with thionine (0.1%) in acetate buffer (pH = 3.9). The L4 to L5 regions were identified according to standard anatomical guidelines described in [67] using an Olympus BX61 upright light microscope with 10x, 20x and 40x objectives. Briefly, the L4 and L5 sections were identified according to the area of the gracile fasciculus and dorsal corticospinal tract relative to the spinal cord central canal.…”
Section: Methodsmentioning
confidence: 99%
“…Every tenth consecutive L4 and L5 spinal cord section was counted until the sacral dorsal commissural nucleus appeared concomitant with a decrease in size of the gracile fasciculus and dorsal corticospinal tract, which are markers for L6. Motor neurons were identified by a large, darkly stained cell body, a pale nucleus with a continuous boundary and one or more darkly stained nucleoli [67]. …”
Section: Methodsmentioning
confidence: 99%
“…Using the most reliable electrophysiological method for MUNE, the exponential nature of lower motor neuron loss over time in both ALS patients and SOD1-linked FALS patients has recently been demonstrated in all of the muscles examined (Baumann et al, 2010, 2012). Furthermore, MUNE values obtained with the Bayesian method show a solid correlation with the actual number of lower motor neurons in the spinal cord, determined by histology (Ngo et al, 2012). The exponential kinetics of neuronal cell loss is consistent with the “one-hit” model of neurodegeneration described by Clarke et al (2000).…”
Section: An Alternative View Of Prion-like Propagation In Sod1-linkedmentioning
confidence: 86%