The relationship between birth and placental weights changes with placental size

Salafia, Carolyn M.; Dygulska, Beata; Perez-Avilan, Gabriela; Schmitt, Rebecca; Roberts, Drucilla J.; Ma, Xilu; Misra, Dawn P.; Dunn, Alana Devine; Ngu, Sam; Inany, H.; Khawar, Nayaab; Giashuddin, Shah; Narula, Pramod; Lederman, Sanford

doi:10.1016/j.earlhumdev.2017.05.011

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Earlier reports stated that the placental weight and birth weight showed positive correlation. 9,3,15 Our results supports this earlier reports as there was a significant positive correlation between the placental weight and the neonatal weight in the present study. Udainia and Jainin 2001 also reported linear relation existed between the placenta weight and newborn weight in uncomplicated,mild and severe pregnancy induced hypertension.…”

Section: Discussionsupporting

confidence: 93%

“…2 As placenta plays a key role in the survival of fetus and is the major communication between the mother and fetus, the effect of maternal disorders on the neonatal outcome can be assesed by studying placenta. 3 The placenta at term is almost a circular disk with a diameter of 15-20 cm and thickness of about 3 cm at its center. It feels spongy and weighs about 500 gm, the proportion to the weight of the baby being roughly 1:6 at term.…”

Section: Methodsmentioning

confidence: 99%

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Correlation of placental morphometry with the birth weight of newborn in Kerala population

Rajeev

Goothy

Chitra

2020

J Bangladesh Soc Physiol

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Background:Morphology and morphometric measurements of the placenta will provide an insight into the aetiology of newborn and maternal complications. Objective:This study aimed to observe the gross morphometric assessment of placenta and to correlate the placental indices with birth weight of the baby in hypertensive and normal pregnancies. Methods:The present study was a comparative descriptive study with analytical components. A total of 86 pregnant women comprising 40 normotensive subjects and 46 hypertensive women within the age group of 18-40 years, parity between 1-4, gestational age between 37 weeks-40 weeks, who attended antenatal clinic of the hospital and delivered by either vaginal route or caesarean section were included in this study. After collecting their placenta, the weight, diameter, surface area, thickness, shape of the placentae was recorded. Weight and sex of baby was also recorded. For statistical analysis, Pearson correlation coefficient test was employed. Results: Positive correlation was observed between the placental surface area (p<0.05; p<0.001), diameter (p<0.05; p<0.001) weight (p<0.001; p<0.05) and the corresponding birth weight of the baby among both the normotensive and the hypertensive mothers. All these relationships were statistically significant. Conclusion: From this study, it can be concluded that placental morphometry has a direct relationship with the birth weight of the baby irrespective of the blood pressure of the mother during pregnancy.The study results may help in understanding of the maternal-placental programming of chronic diseases J Bangladesh Soc Physiol. 2020, December; 15(2): 91-97

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Correlation of placental morphometry with the birth weight of newborn in Kerala population

Rajeev

Goothy

Chitra

2020

J Bangladesh Soc Physiol

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“…26 , 27 Further, a higher fetal-placental weight ratio may also indicate reduced reserve capacity, which may increase susceptibility to additional stressors. 26…”

Section: Discussionmentioning

confidence: 99%

“…25 A larger fetal-placental weight ratio may reflect increased placental efficiency to compensate for MVM; however, higher fetal-placental weight ratios are also associated with adverse outcomes, indicating that compensation may be inadequate. 26,27 Further, a higher fetal-placental weight ratio may also indicate reduced reserve capacity, which may increase susceptibility to additional stressors. 26 In the group analysis, we observed that several groups characterized by AI (groups 6b, 7c, 9a) were more common among early PTB.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 Further, a higher fetal-placental weight ratio may also indicate reduced reserve capacity, which may increase susceptibility to additional stressors. 26 In the group analysis, we observed that several groups characterized by AI (groups 6b, 7c, 9a) were more common among early PTB. Mechanistically, this may be a result of preterm birth secondary to premature rupture of membranes/clinical chorioamnionitis.…”

Section: Discussionmentioning

confidence: 99%

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Formulating a Meaningful and Comprehensive Placental Phenotypic Classification

et al. 2021

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Introduction While many placental lesions have been identified and defined, the significance of multiple overlapping lesions has not been addressed. The purpose of our analysis was to evaluate overlapping patterns of placental pathology and determine meaningful phenotypes associated with adverse birth outcomes. Methods Placental pathology reports were obtained from a single hospital between 2009 and 2018. Placental lesions were grouped into four major categories: acute inflammation (AI), chronic inflammation (CI), maternal vascular malperfusion (MVM), and fetal vascular malperfusion (FVM). Within each category, lesions were classified as not present, low grade or high grade. Combinations of pathologies were evaluated in relation to preterm birth (<37 weeks) and small for gestational age (SGA) infant (birthweight <10th percentile). Results During the study period, 19,027 placentas were reviewed by pathologists. Results from interaction models indicate that MVM and MVM in combination with CI and/or FVM are associated with the greatest odds of SGA infant and PTB. When incorporating grade, we identified 21 phenotype groups, each with characteristic associations with the SGA infant and patterns of PTB. Discussion We have developed a comprehensive and meaningful placental phenotype that incorporates severity and multiplicity of placental lesions. We have also developed a web application to facilitate phenotype determination ( https://placentaexpression.shinyapps.io/phenotype ).

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Placental Weight, Shape and Gross Vascular Morphology

Salafia

Roberts

2018

Pathology of the Placenta

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The relationship between birth and placental weights changes with placental size

Cited by 6 publications

References 26 publications

Correlation of placental morphometry with the birth weight of newborn in Kerala population

Correlation of placental morphometry with the birth weight of newborn in Kerala population

Formulating a Meaningful and Comprehensive Placental Phenotypic Classification

Placental Weight, Shape and Gross Vascular Morphology

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