The relationship between body mass index and uric acid: a study on Japanese adult twins

Tanaka, Kentaro; Ogata, Soshiro; Tanaka, Haruka; Omura, K.; Honda, Chika; Hayakawa, Kayoko

doi:10.1007/s12199-015-0473-3

Cited by 68 publications

(53 citation statements)

References 41 publications

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“…Another distinct finding in our study was discovering that the highest sUA levels in this sample were detected among females in early childhood (ages 2–5). Other studies (Suzuki et al, ; Tanaka et al, ) have identified the gender‐specificity of serum uric acid in adult populations, but few among youth. One possible explanation for the high sUA levels detected in girls in early childhood (ages 2–5) is that they had significantly higher BMI percentiles than their male counterparts.…”

Section: Discussionmentioning

confidence: 99%

Association between body mass index and salivary uric acid among Mexican‐origin infants, youth and adults: Gender and developmental differences

Martínez

Ruelas

2016

Developmental Psychobiology

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Uric acid (UA) is the end product of the metabolic breakdown of purine nucleotides. Recent studies have measured UA in saliva in relation to obesity and chronic disease risk. Given the increasing prevalence of metabolic syndrome among Latino youth, we examined gender and age differences in salivary uric acid (sUA) and weight in a sample of Mexican-origin children (n = 65, 2 months to 18 years, 49% female) and adults (n = 46, 19-58 years, 72% female). We measured weight, height, waist, and hip circumference and collected saliva samples (later assayed for sUA). Structural equation models estimated the relationship between age, developmental stage, and weight outcomes in relation to sUA levels between genders, while controlling for race. Results demonstrate that increased sUA levels were related to higher BMI percentiles in females of all ages (β = 0.43, p < .001). There were significant differences in sUA levels between developmental stages for girls, with female toddlers having the highest sUA levels (β = .28, p = .02). In an interaction between BMI z-score and gender between youth and adults, BMI has a larger effect on increasing sUA levels among younger girls (β = 0.27, p < .03) and adult women (β = 0.33, p = .02). Levels of sUA may be gender-specific in relation to BMI and developmental stage.

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Section: Discussionmentioning

confidence: 99%

Association between body mass index and salivary uric acid among Mexican‐origin infants, youth and adults: Gender and developmental differences

Martínez

Ruelas

2016

Developmental Psychobiology

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“…The relation between SUA and anthropometric measures of overall adiposity is well established. Several studies found cross-sectional associations between BMI or WC with SUA or hyperuricemia [26][27][28] . Moreover, SUA levels have predictive ability with respect to weight gain.…”

Section: Discussionmentioning

confidence: 99%

Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging

Rospleszcz

Dermyshi

Müller-Peltzer

et al. 2020

Sci Rep

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Elevated serum uric acid (SUA) is associated with a variety of medical conditions, such as hypertension, diabetes and obesity. Analyses investigating uric acid and obesity were primarily conducted using anthropometric measures like BMI and waist circumference. However, different adipose tissue depots might be differentially affected in uric acid metabolism. We analyzed the relation of SUA with visceral, subcutaneous and hepatic fat as quantified by Magnetic Resonance Imaging in N = 371 individuals from a cross-sectional sample of a population-based cohort. Associations of SUA and fat depots were calculated by regressions adjusted for potential confounders. We found that SUA was correlated with all fat measures (e.g. Pearson's r between SUA and hepatic fat: 0.50, 95%-CI: 0.42, 0.57). Associations with visceral and hepatic fat, but not with subcutaneous fat, remained evident after adjustment for anthropometric measures (e.g. visceral fat: β = 0.51 l, 95%-CI: 0.30 l, 0.72 l). In conclusion, these results show how different adipose tissue compartments are affected by SUA to varying degrees, thus emphasizing the different physiological roles of these adipose tissues in uric acid metabolism.

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“…Furthermore, not only elevated SUA concentrations were associated with the increasing risk of obesity, but obesity was also associated with higher risk of hyperuricemia. For example, Tanaka et al 26. found that BMI was significantly associated with SUA in Japanese adult twins, after adjusting for both genetic and familial environment factors.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes

Chen

Zhao

et al. 2017

Sci Rep

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We aim to explore the associations between serum uric acid (SUA) and obesity and cardio-cerebrovascular events (CCEs) in Chinese inpatients with type 2 diabetes mellitus (T2DM). 2 962 inpatients with T2DM were stratified into quartile based on SUA concentrations. There were significant increases in the prevalence of both obesity (32.6%, 41.9%, 50.1%, and 62.8%, respectively, p < 0.001 for trend) and severe obesity (0.4%, 0.6%, 0.8%, and 1.3%, respectively, p < 0.001 for trend) across the SUA quartiles. A fully adjusted multiple logistic regression analysis revealed that SUA quartiles were independently associated with the presence of obesity (p < 0.001). The prevalence of CCEs was significantly higher in the obese diabetics than in the nonobese diabetics (16.8% vs. 13.2%, p = 0.027). After controlling for multiple confounding factors, BMI levels were also significantly correlated with the presence of CCEs (p = 0.020). However, there was no significant association of SUA quartiles/SUA levels with the presence of CCEs in T2DM. This study suggested that SUA levels were independently associated with obesity but not with CCEs in patients with T2DM. In selected populations such as subjects with T2DM, the role of uric acid in cardiovascular complications might be attributable to other cardiovascular risk factors, such as obesity.

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The relationship between body mass index and uric acid: a study on Japanese adult twins

Cited by 68 publications

References 41 publications

Association between body mass index and salivary uric acid among Mexican‐origin infants, youth and adults: Gender and developmental differences

Association between body mass index and salivary uric acid among Mexican‐origin infants, youth and adults: Gender and developmental differences

Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging

Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes

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