“…However, modern specific studies of this variable by authors such as Jahari AB et al on an Indonesian population (Jahari, 2000), Fleshman AK on an African population (Fleshman, 2000), and Melsen B et al on a population of adopted foreign minors in Denmark (Melsen et al, 1996) clearly identify socio-economic factors and poverty as causing significant delay in the rate of the bone maturation sequence during the prepubertal period. Pathological factors clearly identified as altering bone age maturation rate include, among others, nocturnal enuresis (Dundaroz et al, 2001), GH deficit (Vallejo- Bolaños et al, 1999), obesity , high-level competitive sport activities (Theintz et al, 1993) or bone malformations, and exposure to physical agents causing injury such as frostbite (Freyshmidt et al, 2001). …”