The Relationship between Cancer and Alzheimer's Disease

Tirumalasetti, Fughik; Han, Luke; Birkett, D. Peter

doi:10.1111/j.1532-5415.1991.tb02713.x

Cited by 29 publications

(19 citation statements)

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“…The first evidence came from autopsy studies which found that patients with AD had substantially fewer incident cancers than aged-matched controls. 26,27 This is unexpected, since patients with dementia are generally under-diagnosed with cancer and might be expected to have more incidental tumors. In a study of atomic bomb survivors, people with clinically diagnosed AD had a 70% decreased risk of prior cancer compared to age-matched subjects without dementia, while those with vascular dementia had an 60% increased risk of cancer.…”

Section: An Unusual Cancer Pattern In Pd and Admentioning

confidence: 95%

Understanding the link between cancer and neurodegeneration

Driver

2012

Journal of Geriatric Oncology

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Section: An Unusual Cancer Pattern In Pd and Admentioning

confidence: 95%

Understanding the link between cancer and neurodegeneration

Driver

2012

Journal of Geriatric Oncology

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“…However, as was highlighted [29] , the risk of cancer is also greatly influenced by other fac- tors such as diet and life habits (for example: a fat-and protein-based diet is associated with several common types of cancer like breast and colon cancer), which are also associated with the etiology of cognitive disorder and dementia, which could occur before cancer and its treatment, and these were not controlled in the study cited [28] . On the other hand, regarding Alzheimer's disease, some cross-sectional and case-control studies had previously found a relation between cancer history and Alzheimer's disease [30][31][32] . Recently, in a prospective study, the authors [33] reported that the patients with Alzheimer's disease presented a slower cancer progression (p !…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Cognitive and Functional Impairment in a Community Sample from São Paulo, Brazil

Hototian¹,

Lopes²,

Azevedo³

et al. 2007

Dement Geriatr Cogn Disord

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Aims: To present the prevalence of cognitive and functional impairment (CFI) in community-dwelling elderly subjects from the city of São Paulo. Methods: The population was aged 60 years and older (n = 1,563; 68.7% women and 31.3% men) and lived in different socioeconomic areas. The following instruments were administered to the elderly: the Mini Mental State Examination and the Fuld Object Memory Evaluation. The Informant Questionnaire on Cognitive Decline in the Elderly and the Bayer-Activities of Daily Living scale were administered to an informant. Results: The prevalence of CFI (n = 250) was 16% (95% confidence interval, CI: 14.2–17.8%) or 15.8% (95% CI: 13.8–17.8%). In regression models, the increase in the odds ratio (OR) of CFI was associated with age, for elderly individuals aged 75 years or older, illiterates or with 1–4 years of schooling, and with a history of stroke and diabetes mellitus. On the other hand, for subjects with a tumor history, the OR of CFI was significantly reduced. Conclusion: CFI was high and increased at older ages and in subjects with low education. Potentially changeable factors were identified (stroke and diabetes), and the possible ‘protective effect’ of tumor/cancer against CFI should be further investigated by longitudinal studies.

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“…The first evidence of an inverse association between AD and cancer came from autopsy [82, 83] and case control studies [84, 85]. Over the past decade, a number of cohort studies have found convincing evidence that cancer survivors develop less AD than expected, and that patients with AD develop less cancer [86–90].…”

Section: Epidemiologic Evidence For the Inverse Relationship Betwementioning

confidence: 99%

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

Driver

Zhou

2015

Biochimica et Biophysica Acta (BBA) - General Subjects

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BACKGROUND Pin1 is an intracellular signaling molecule which plays a critical but opposite role in the pathogenesis of Alzheimer’s disease (AD) and many human cancers. SCOPE OF REVIEW We review the structure and function of the Pin1 enzyme, the diverse roles it plays in cycling cells and neurons, the epidemiologic evidence for the inverse association between cancer and AD, and the potential therapeutic implications of Pin1-based therapies. MAJOR CONCLUSIONS Pin1 is a unique enzyme that has effects the function of target proteins by “twisting” them into different shapes. Cycling cells use Pin1 to help coordinate cell division. It is over-expressed and/or activated by multiple mechanisms in many common human cancers, and acts on multiple signal pathways to promote tumorigenesis. Inhibition of Pin1 in animal models has profound anti-tumor effects. In contrast, Pin1 is down-regulated or inactivated by multiple mechanisms in AD brains. The absence of Pin1 impairs tau function and amyloid precursor protein processing, leading to tangle- and amyloid-related pathologies and neurodegeneration in an age-dependent manner, resembling human AD. We have developed cis and trans conformation-specific antibodies to provide the first direct evidence that tau exists in distinct cis and trans conformations and that Pin1 accelerates its cis to trans conversion, thereby protecting against tangle formation in AD. GENERAL SIGNIFICANCE Available studies on Pin1 suggest that cancer and AD may share biological pathways that are deregulated in different directions. Pin1 biology opens exciting preventive and therapeutic horizons for both cancer and neurodegeneration.

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The Relationship between Cancer and Alzheimer's Disease

Cited by 29 publications

References 1 publication

Understanding the link between cancer and neurodegeneration

Understanding the link between cancer and neurodegeneration

Prevalence of Cognitive and Functional Impairment in a Community Sample from São Paulo, Brazil

Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

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