The relationship between central corneal thickness-adjusted intraocular pressure and glaucomatous visual-field loss

Sullivan-Mee, Michael; Halverson, Kathy D.; Saxon, Glenn B.; Saxon, Mollie C.; Shafer, Kathleen M.; Sterling, Jeffrey A.; Sterling, Melissa J.; Qualls, Clifford

doi:10.1016/s1529-1839(05)70298-0

Cited by 20 publications

(8 citation statements)

References 39 publications

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“…Corneal thickness of these subjects was measured using the Orbscan II optical pachometry system (Orbtek, Inc., Salt Lake City, UT) to account for the effect of central corneal thickness on tonometry. All IOP values were corrected using the formula: P = A+(550 -T) / X, where P = IOP in mmHg, A = Goldmann applanation reading in mmHg, T = central corneal thickness in μm, X = the correction ratio [28]. The mean IOP of all eyes was 23.3 ± 0.86 mmHg after compensation for the central corneal thickness.…”

Section: Subjectsmentioning

confidence: 99%

Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

Chu

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Section: Subjectsmentioning

confidence: 99%

Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

Chu

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…[1][2][3] CCT has been identified as a substantial glaucoma risk factor, [4][5][6][7][8] and glaucomatous damage often presents in an asymmetric fashion. 9,10 The percentage of normal-tension and hightension glaucoma patients with unilateral VF loss has been estimated to be approximately 25-35%.…”

Section: Introductionmentioning

confidence: 99%

Differences in central corneal thickness between the paired eyes and the severity of the glaucomatous damage

Iester

Telani

Frezzotti

et al. 2012

Eye

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Purpose To evaluate whether a difference in central corneal thickness (CCT) between the paired eyes could be associated to worse glaucoma in the thinner cornea eye. Methods From 16 different glaucoma centres, at least 50 glaucomatous patients were saved on the Italian Glaucoma Register. Eight hundred and sixteen glaucomatous patients were found in the register. CCT, ophthalmoscopic cup/disc ratio, mean deviation (MD), pattern SD (PSD), and intraocular pressure (IOP). The difference (D) between the paired eyes was calculated for all the considered parameters and two subgroups were created on the basis of DCCT. Because the difference between the two eyes could be positive or negative, the absolute value of D was considered for all the measurements. Three different DCCT cutoffs were selected: 10, 15, and 20 mm. Student's t-test was used to compare the subgroups. Results When the entire group was divided in two subgroups using 20 mm as DCCT cutoff, no significant difference was found for DIOP ( À 0.38 ± 2.53 (mean ± SD) mm Hg and À 0.07 ± 2.35 mm Hg, respectively) between the two subgroups. Significant (Po0.001) difference was found for DMD (6.58 ± 7.30 and 3.14 ± 4.22 dB, respectively), DPSD (3.92 ± 4.01 and 2.16±2.57, respectively), and DC/D (0.11±0.14 and 0.08±0.11, respectively) between the two subgroups. No significant correlation was found between DCCT and the other parameters. Conclusion The DCCT between the two eyes could be associated to a worse glaucoma in the thinner cornea eye. Keywords: glaucoma; central corneal thickness; visual field damage; difference between eyes IntroductionAs glaucoma is a chronic asymmetric progressive degenerative disease of the optic nerve head, most patients with glaucoma can have a different stage of the disease between the two eyes.Although central corneal thickness (CCT) measurements are usually highly symmetric between paired eyes, approximately 6-7% of individuals do manifest significant interocular CCT asymmetry. 1-3 CCT has been identified as a substantial glaucoma risk factor, 4-8 and glaucomatous damage often presents in an asymmetric fashion. 9,10 The percentage of normal-tension and hightension glaucoma patients with unilateral VF loss has been estimated to be approximately 25-35%. 9 Asymmetric CCT was already associated with asymmetric primary open-angle glaucoma (POAG) in a retrospective study. 11 In a later study by the same group, however, asymmetric POAG was associated with asymmetric dynamic contour tonometry but not Goldmann applanation tonometry or CCT. 12 The aim of the study was to evaluate whether a difference in CCT between paired eyes could be associated to worse glaucoma in the thinner cornea eye. Patients and methodsThis is a retrospective, cross-sectional study. Institutional review boards and ethics committees at the institutions gave their approval of this study. This study followed the principles of the Declaration of Helsinki.From 16 different glaucoma centres, at least 50 glaucomatous patients for each centre were saved on the Italian G...

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“…This is consistent with the long-held belief that damage to components of the aqueous outflow pathways by reactive oxygen species (ROS) contributes to elevated IOP, a common feature observed in POAG (Siegfried et al, 2015). In other studies a correlation between CCT, optic nerve head topography, and visual field damage was found (Cankaya et al, 2008; Coman et al, 2014; Iester et al, 2012; Insull et al, 2010; Kaushik et al, 2006; Mokbel and Ghanem, 2010; Pakravan et al, 2007; Papadia et al, 2007; Saenz-Frances et al, 2015; Sullivan-Mee et al, 2005). The relationship between POAG risk and CCT is complex and poorly understood.…”

Section: Genetic Analyses Of Poag-associated Traits (Endophenotypes)mentioning

confidence: 74%

Major review: Molecular genetics of primary open-angle glaucoma

Liu

Allingham

2017

Experimental Eye Research

127

106

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Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.

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The relationship between central corneal thickness-adjusted intraocular pressure and glaucomatous visual-field loss

Cited by 20 publications

References 39 publications

Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

Luminance-modulated adaptation in the global flash mfERG: a preliminary study of early retinal functional changes in high-risk glaucoma patients

Differences in central corneal thickness between the paired eyes and the severity of the glaucomatous damage

Major review: Molecular genetics of primary open-angle glaucoma

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