The Relationship between Changes in Body Mass Index and Retinal Vascular Caliber in Children

Kurniawan, Emil D; Cheung, Carol Y.; Tay, Wan Ting; Mitchell, Paul; Saw, Seang‐Mei; Wong, Tien Yin; Cheung, Ning

doi:10.1016/j.jpeds.2014.08.033

Cited by 23 publications

(37 citation statements)

References 42 publications

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“…[42] found association between obesity and hypermetropia in boys; Kurniawan et al . [47] detected in the entire cohort -2.23±1.45 D SE, although unrelated to obesity. An isolated finding in the series studied by Akinci et al .…”

Section: Resultsmentioning

confidence: 83%

“…Three studies assessed both SAH and overweight [34, 36, 37]. Further five studies assessed SAH [10, 38-41] and the remaining eleven studies assessed the effects of overweight [6, 22, 24, 25, 35, 42-47], as described in Tables ( 1 and 2 ). The methodological quality of the studies is described in (Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Kurniawan et al . [47] found that for every 1 kg/m 2 increase in BMI, retinal venular caliber increased by 0.59μ. Cheung et al .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Ocular Signs Related to Overweight and Arterial Hypertension in Children: A Systematic Review

Schuh¹,

Piccoli²,

Paiani³

et al. 2017

TOOPHTJ

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Background:The ocular effects of obesity and hypertension need to be established and can be used as prognostic markers.Objective:To estimate the prevalence of ophthalmological alterations in children and adolescents who are overweight and/or have SAH.Methods:The database for this study included all observational studies (CS, cohort, case-control and “baseline” description of randomized clinical trials) with children and/or adolescents who were overweight, obese or had SAH and that measured ophthalmological alterations.Results:Comparative studies with healthy children demonstrated positive association between body adiposity with retinal venular dilation, and SAH with retinal arteriolar narrowing. Different retinal fundus cameras and computer-assisted programs to evaluate the retinal vessels, variations in the methods of analysis, adjustments, populations, were the main arguments against formal meta-analysis. The heterogeneity was too high (I2 >90%, in fixed or randomized effects), and the lack of linearity, normal distribution and homoscedasticity did not recommend meta-regression.Conclusion:Obesity and SAH show associations with ophthalmological alterations, especially with retinal vessel diameter. Lack of standardization does not allow a quantitative evaluation.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ocular Signs Related to Overweight and Arterial Hypertension in Children: A Systematic Review

Schuh¹,

Piccoli²,

Paiani³

et al. 2017

TOOPHTJ

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“…Details of the study population and recruitment procedures are described in detail elsewhere22. Briefly, schoolchildren from three schools in Singapore aged seven to nine years at baseline were enrolled and examined in 2001 and 2006.…”

Section: Methodsmentioning

confidence: 99%

Evidence of Microvascular Changes in the Retina following Kawasaki Disease

Chen

Burgner

Wong

et al. 2017

Sci Rep

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It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness. Standardised retinal photographs were graded by trained technicians using a semi-automated software, which quantifies the retinal microvasculature (calibre, branching angle, fractal dimensions, and tortuosity). Retinal venules of Singaporean KD patients were 9.67 μm (95% CI 4.87 to 14.51, p < 0.001) larger than control participants following correction for traditional cardiovascular risk factors. An incremental increase in the size of retinal venules in those with coronary artery abnormalities was observed. There was limited evidence that retinal venules were larger in Australian KD patients with coronary artery abnormalities compared to control participants (7.34 μm, 95% CI 1.30 to 15.99, p = 0.10). Differences in retinal microvasculature were particularly evident in Singaporean KD patients. Larger retinal venules may reflect chronic inflammation and endothelial dysfunction, and are associated with coronary artery disease in adults.

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“…But HOMA-IR levels and incidence of hyperinsulinsm were significantly higher in obese children. CO and IR are also characterized by impaired immunity and a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species [1,[6][7][8][15][16][17]. We thought that dry eye may be correlated with obesity in these children based on the role of this inflammation leading to overweight and obesity.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of ophthalmic manifestations according to insulin resistance, lipid and pubertal status in obese and healthy children

Kurtul¹,

Kabataş²,

Özer³

et al. 2017

Eye Care Vis

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Purpose: We aimed to evaluate the ophthalmic manifestations in terms of insulin resistance (IR), lipid and pubertal status in obese and healthy children.Methods: Subjects (aged from 5 to17 years) were divided into 2 groups according to their body mass index (BMI) percentiles as obese and non-obese and 4 subgroups according to absence or presence of insulin resistance, hyperlipidemia and pubertal status. Sixty obese children (BMI >95th percentile), 58 healthy control subjects with the same age range (BMI <85th percentile) were admitted to this prospective study. Demographic features and laboratory measurements of subjects were recorded. Ophthalmological examination, including ocular surface parameters, intraocular pressure, central corneal thickness (CCT), and biometric measurements were assed among subgroups. Results:The subjects in obese group were significantly more hypertensive than control group [13 patients (21.7%), and 1 patient (1.7%) respectively, (p=0.001)]. Incidence of hyperinsulinism and the homeostasis model assessment for IR (HOMA-IR) levels and of obese children were significantly higher than control group (p=0.003, and p=0.034, respectively). The rate of hypertensive retinopathy was significantly higher in obesity (+) hyperlipidemia (+) subgroup (p=0.002). The mean CCT values were significantly lower in obesity (+) IR (+) subgroup (p=0.023). Schirmer test scores were significantly lower in obesity (-) subgroups regardless of IR, lipid and pubertal status. Conclusions:Our findings suggest that decreased CCT levels may be related to presence of IR in obese children. The coexistence of hypertensive retinopathy with hyperlipidemia may occur in childhood obesity.

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The Relationship between Changes in Body Mass Index and Retinal Vascular Caliber in Children

Cited by 23 publications

References 42 publications

Ocular Signs Related to Overweight and Arterial Hypertension in Children: A Systematic Review

Ocular Signs Related to Overweight and Arterial Hypertension in Children: A Systematic Review

Evidence of Microvascular Changes in the Retina following Kawasaki Disease

Evaluation of ophthalmic manifestations according to insulin resistance, lipid and pubertal status in obese and healthy children

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