The Relationship Between Chemokine and Chemokine Receptor Genes Polymorphisms and Chronic Obstructive Pulmonary Disease Susceptibility in Tatar Population from Russia: A Case Control Study

Korytina, G. F.; Aznabaeva, Yu. G.; Akhmadishina, L. Z.; Kochetova, O. V.; Nasibullin, T. R.; Загидуллин, Н. Ш.; Zagidullin, Shamil; Викторова, Т. В.

doi:10.1007/s10528-021-10087-2

Cited by 8 publications

(10 citation statements)

References 64 publications

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“…All participants of this study provided written informed consent and the study was approved by the Local Research Ethics Committee (Ufa, Protocol No 17, December 07, 2010). We included unrelated subjects of self-reported ethnic Tatar population; all details have been previously described [26,27] . The participants were recruited through the pulmonary departments of Ufa City Hospitals No.…”

Section: Study Populationmentioning

confidence: 99%

“…The smoker group includes 484 COPD patients and 517 healthy individuals, while the non-smoker group includes 117 COPD patients and 100 healthy individuals. Details of inclusion and exclusion criteria for case and control groups have been previously described [24,26] . Briefly, to determine pulmonary function, measures of forced expiratory volume in 1 second (FEV 1 ) and forced vital capacity (FVC) were derived in accordance with American Thoracic Society/European Respiratory Society criteria [28] .…”

Section: Study Populationmentioning

confidence: 99%

“…Briefly, to determine pulmonary function, measures of forced expiratory volume in 1 second (FEV 1 ) and forced vital capacity (FVC) were derived in accordance with American Thoracic Society/European Respiratory Society criteria [28] . COPD was diagnosed according to the Tenth Revision of the International Classification of Diseases (ICD 10) (http:// www.who.int/classifications/icd/en/) and in accordance with the recommendations of the Global Initiative on COPD (GOLD; http www.goldcopd.org) [26,27] . Baseline demographics and clinical characteristics of studied groups are presented in Table 1.…”

Section: Study Populationmentioning

confidence: 99%

“…Eleven SNPs of inflammatory genes (Table 2), including FASLG (rs763110), IL19 (rs2243193), IL20 (rs2981573), IL24 (rs291107), PPBP (rs352010), IL4 (rs2243250), IL4 (rs2070874), С5 (rs17611), FAS (rs1800682), IL4RA (rs1805010), and TGFb1 (rs1800469), were selected for the study based on the following criteria [26,27] : (i) Associations with complex human diseases; (ii) functional effect of SNP on gene expression or relation to non-synonymous substitutions; and (iii) minor allele frequency (MAF) of ≥5% in the European populations (http://www. internationalgenome.org/).…”

Section: Gene and Snps Selection And Genotypingmentioning

confidence: 99%

“…Previously, we identified the association of chemokines genes with COPD risk in the Tatar population from Russia [26] . In this study, we aimed to assess the association of single nucleotide polymorphisms (SNPs) of IL19, IL20, IL24, PPBP, IL4, IL4RA, С5, FAS, FASLG, and TGFb1 genes singly and in combinations with COPD in smokers and non-smokers to evaluate the gene-gene and geneenvironment interactions in COPD development.…”

Section: Introductionmentioning

confidence: 99%

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Gene-gene and gene-environment interactions of the inflammatory gene variants in the development of chronic obstructive pulmonary disease

Korytina¹,

Aznabaeva²,

Nasibullin³

et al. 2022

Global Transl Med

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Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease that is characterized by partly reversible airflow limitation, chronic inflammation, fibrosis of small airways, and destruction of lung parenchyma. We aimed to assess the association of the inflammatory gene loci singly and in combinations with COPD in smokers and non-smokers in ethnic Tatar from Russia to evaluate the gene-gene and gene-environment interactions in COPD development. Eleven loci of inflammatory genes, including IL19, IL20, IL24, PPBP, IL4, IL4RA, С5, FAS, FASLG, and TGFb1, were genotyped in 484 smoking COPD patients, 517 healthy smokers, 117 non-smoking COPD patients, and 100 healthy non-smokers. Significant associations with COPD in smokers were identified for IL19 (rs2243193), IL4 (rs2243250), IL4 (rs2070874), and PPBP (rs352010). In non-smokers, associations were established for IL24 (rs291107), IL4 (rs2070874), and PPBP (rs352010). Associations of inflammatory genes loci IL19 (rs2243193), IL4 (rs2070874), TGFb1 (rs1800469), PPBP (rs352010), and FASLG (rs763110) and smoking index were determined. Associations of FAS (rs1800682), FASLG (rs763110), IL4 (rs2243250), IL4RA (rs1805010), and PPBP (rs352010) loci with pulmonary function variables were observed. The results of gene-gene interactions analysis showed distinctive patterns of association of inflammatory gene loci with COPD in groups stratified by smoking status. The combination of A allele of IL19 (rs2243193), C allele of IL4 (rs2243250), and T allele of PPBP (rs352010) was the main component of the majority of protective gene-gene combination associated with COPD in smokers. The highest risk of COPD was conferred by TT genotype of PPBP (rs352010) in combination with A allele of FAS (rs1800682). While in non-smokers, the most commonly featured was IL24 (rs291107) C allele in protective patterns and IL24 (rs291107) T allele in predisposing combinations. The highest risk of COPD in non-smokers was detected in a gene-gene combination consisting of A allele of IL12RB2 (rs3762317) together with G allele of IL12A (rs2243115), C allele of IL4 (rs2070874), and A allele of IL4RA (rs1805010).

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Section: Study Populationmentioning

confidence: 99%