The Relationship Between Child Mortality Rates and Prevalence of Celiac Disease

Biagi, Federico; Raiteri, Alberto; Schiepatti, Annalisa; Klersy, Catherine; Corazza, Gino Roberto

doi:10.1097/mpg.0000000000001696

Cited by 8 publications

(5 citation statements)

References 50 publications

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“…Specific guidelines are lacking in these geographical areas[ 79 ]. In addition, the incidence of undiagnosed CD in children can be extremely high[ 80 ]. Knowing the high mortality and disability related to untreated CD in childhood, it would be advisable to develop specific protocols for specific geographical areas.…”

Section: Discussionmentioning

confidence: 99%

Current guidelines for the management of celiac disease: A systematic review with comparative analysis

Raiteri¹,

Granito²,

Giamperoli³

et al. 2022

WJG

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BACKGROUND Wheat and other gluten-containing grains are widely consumed, providing approximately 50% of the caloric intake in both industrialised and developing countries. The widespread diffusion of gluten-containing diets has rapidly led to a sharp increase in celiac disease prevalence. This condition was thought to be very rare outside Europe and relatively ignored by health professionals and the global media. However, in recent years, the discovery of important diagnostic and pathogenic milestones has led to the emergence of celiac disease (CD) from obscurity to global prominence. These modifications have prompted experts worldwide to identify effective strategies for the diagnosis and follow-up of CD. Different scientific societies, mainly from Europe and America, have proposed guidelines based on CD's most recent evidence. AIM To identify the most recent scientific guidelines on CD, aiming to find and critically analyse the main differences. METHODS We performed a database search on PubMed selecting papers published between January 2010 and January 2021 in the English language. PubMed was lastly accessed on 1 March 2021. RESULTS We distinguished guidelines from 7 different scientific societies whose reputation is worldwide recognized and representative of the clinical practice in different geographical regions. Differences were noted in the possibility of a no-biopsy diagnosis, HLA testing, follow-up protocols, and procedures. CONCLUSION We found a relatively high concordance between the guidelines for CD. Important modifications have occurred in the last years, especially about the possibility of a no-biopsy diagnosis in children. Other modifications are expected in the next future and will probably involve the extension of the non-invasive diagnosis to the adult population and the follow-up modalities.

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Section: Discussionmentioning

confidence: 99%

Current guidelines for the management of celiac disease: A systematic review with comparative analysis

Raiteri¹,

Granito²,

Giamperoli³

et al. 2022

WJG

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“…The worldwide prevalence of CD is 860 per 100,000 population. 126 The most common cardiac arrhythmia in CD is AF, with a reported incidence 30% higher than in the general population. 127 An elevated risk of ventricular arrhythmias (multiform and repetitive couplets of PVC) has been also reported.…”

Section: Celiac Diseasementioning

confidence: 99%

Cardiac Arrhythmias in Autoimmune Diseases

Gawałko

Balsam

Lodziński

et al. 2020

Circ J

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Autoimmune diseases (ADs) affect approximately 10% of the world's population. Because ADs are frequently systemic disorders, cardiac involvement is common. In this review we focus on typical arrhythmias and their pathogenesis, arrhythmia-associated mortality, and possible treatment options among selected ADs (sarcoidosis, systemic lupus erythematosus, scleroderma, type 1 diabetes, Graves' disease, rheumatoid arthritis, ankylosing spondylitis [AS], psoriasis, celiac disease [CD], and inflammatory bowel disease [IBD]). Rhythm disorders have different underlying pathophysiologies; myocardial inflammation and fibrosis seem to be the most important factors. Inflammatory processes and oxidative stress lead to cardiomyocyte necrosis, with subsequent electrical and structural remodeling. Furthermore, chronic inflammation is the pathophysiological basis linking AD to autonomic dysfunction, including sympathetic overactivation and a decline in parasympathetic function. Autoantibody-mediated inhibitory effects of cellular events (i.e., potassium or L-type calcium currents, M2 muscarinic cholinergic or β1-adrenergic receptor signaling) can also lead to cardiac arrhythmia. Drug-induced arrhythmias, caused, for example, by corticosteroids, methotrexate, chloroquine, are also observed among AD patients. The most common arrhythmia in most AD presentations is atrial arrhythmia (primarily atrial fibrillation), expect for sarcoidosis and scleroderma, which are characterized by a higher burden of ventricular arrhythmia. Arrhythmia-associated mortality is highest among patients with sarcoidosis and lowest among those with AS; there are scant data related to mortality in patients with psoriasis, CD, and IBD.

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“…That the serological prevalence of CD is increasing in the last 70 years, regardless of our greater capacity to diagnose it at least in industrialized countries, is a fact ascertained by independent studies carried out evaluating the CD positivity in blood banks [11][12][13]. Since the genetic predisposition cannot change in such a short period of time, the increased prevalence of CD in the last 50-70 years could be associated with the reduction of infant mortality rates due to the disease [14] or linked to changes in environmental exposures. Nutrition represents one of the major environmental factors, drastically changed during the last 70 years with the so-called westernization of the diet [15] but certainly not the only one.…”

Section: Position Of the Debate On Ancient Heritage And Modern Wheamentioning

confidence: 99%

Differential Physiological Responses Elicited by Ancient and Heritage Wheat Cultivars Compared to Modern Ones

et al. 2019

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Although ancient, heritage, and modern wheat varieties appear rather similar from a nutritional point of view, having a similar gluten content and a comparable toxicity linked to their undigested gluten peptide, whenever the role of ancient end heritage wheat grains has been investigated in animal studies or in clinical trials, more anti-inflammatory effects have been associated with the older wheat varieties. This review provides a critical overview of existing data on the differential physiological responses that could be elicited in the human body by ancient and heritage grains compared to modern ones. The methodology used was that of analyzing the results of relevant studies conducted from 2010 through PubMed search, by using as keywords “ancient or heritage wheat”, “immune wheat” (protein or peptides), and immune gluten (protein or peptides). Our conclusion is that, even if we do not know exactly which molecular mechanisms are involved, ancient and heritage wheat varieties have different anti-inflammatory and antioxidant proprieties with respect to modern cultivars. It is, therefore, reasonable to assume that the health proprieties attributed to older cultivars could be related to wheat components which have positive roles in the modulation of intestinal inflammation and/or permeability.

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The Relationship Between Child Mortality Rates and Prevalence of Celiac Disease

Cited by 8 publications

References 50 publications

Current guidelines for the management of celiac disease: A systematic review with comparative analysis

Current guidelines for the management of celiac disease: A systematic review with comparative analysis

Cardiac Arrhythmias in Autoimmune Diseases

Differential Physiological Responses Elicited by Ancient and Heritage Wheat Cultivars Compared to Modern Ones

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