The relationship between childhood abuse and depression in a sample of Chinese people who use methamphetamine

Chen, Yanling; Zhang, Junjie; Sun, Yehuan

doi:10.1016/j.ijchp.2019.06.003

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…Some have suggested that self-reported psychotic illness is more prevalent among individuals using crystal methamphetamine than among those using other forms of methamphetamine, which may be associated with the purity of crystal methamphetamine and the self-selection of individuals who use this form of the drug. The psychiatric comorbidity of MUD is complex because there is evidence for both preexisting factors that increase the risk for psychiatric disorders (eg, a 44% prevalence of moderate to severe childhood abuse or neglect) . Moreover, early lifetime adversity, such as emotional or sexual trauma, may also increase the likelihood of MUD owing to the fact that some individuals use methamphetamine as a coping method .…”

Section: Clinical Presentationmentioning

confidence: 99%

Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

2020

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In the wake of the opioid crisis, methamphetamine has reemerged as a challenge to mental health clinicians and researchers alike. Methamphetamine is now available in different forms such as ice, powder, and pills, with different pharmacokinetic characteristics that make them popular among certain types of individuals. 1 Recent seizure data suggest that methamphetamine production and trafficking are spreading into new areas of the globe. 2 According to the Automation of Reports and Consolidated Orders System, methamphetamine consumption increased 4-fold between 2015 and 2016 and total stimulant use doubled in the last decade. 3 From 2011 through 2016, the age-adjusted rate of drug overdose deaths involving methamphetamine more than tripled. 4 Moreover, drug overdose deaths involving cocaine, amphetamines, or both substances combined increased 42.4% from 12 122 in 2015 to 17 258 in 2016. 5 Based on the most recent data from the National Survey on Drug Use and Health, 6 the 12-month prevalence of individuals aged 12 years or older reporting methamphetamine use has increased by 195% from its low in 2010 to 2018 (Figure 1), and it is estimated that 1.86 million Americans used methamphetamine in 2018. These numbers underline the importance of paying attention to the possibility of the next substance use crisis. However, whereas opioid use disorder can be treated pharmacologically 7 and behaviorally, 8 there are significant challenges for the treatment of methamphetamine use disorder (MUD). This review focuses on 3 specific aspects of MUD. First, the neurobiology of methamphetamine is more complex than the traditional view of it as a monoaminergic modulator. Second, the clinical presentation is not limited to the symptoms associated with use disorder but extend to medical presentations, most notably the cardiovascular and cerebrovascular systems. Third, pharmacologic interventions focused on modulating the monoaminergic pathways have largely failed, and new pharmacologic approaches are necessary to focus on novel treatment targets. In the final section, several suggestions will be proposed for both clinicians and researchers to advance the understanding of MUD. Biological Pathways, Neural Basis, and CognitionMethamphetamine has been conceptualized primarily as a releaser of dopamine, serotonin, noradrenaline, and adrenaline from nerve terminals in the central and peripheral nervous system, 9 which occurs via several different mechanisms, including (1) redistributing catecholamines from synaptic vesicles to the cytosol, (2) reversing the plasma membrane transport of neurotransmitters, (3) blocking the activity of monoamine transporters, (4) decreasing the expression of dopamine transporters at the cell surface, (5) inhibiting monoamine oxidase activity, and (6) increasing the activity and IMPORTANCE The prevalence of and mortality associated with methamphetamine use has doubled during the past 10 years. There is evidence suggesting that methamphetamine use disorder could be the next substance use crisis in the United ...

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Section: Clinical Presentationmentioning

confidence: 99%

Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

2020

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“…22 Childhood trauma is a primary risk factor for the development of depressive disorders, post-traumatic stress disorder, implicit emotion regulation deficits, and addictive behavior. [23][24][25] LBA in China suffered a lot of psychotic-trauma experiences (e.g, sexual abuse, bullying victimization) that resulted in loneliness, self-harm behaviors, suicidal ideation and depression. [26][27][28][29] Physical neglect in LBA may result in more severe conduct problems, inattention and hyperactivity index than NLBA.…”

Section: R E T R a C T E Dmentioning

confidence: 99%

RETRACTED: Childhood trauma and internet addiction predict depression on left behind adolescents

Dong

et al. 2021

International Journal of Electrical Engineering & Education

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Objective Parents’ labor migration has resulted in a great quantity of Left Behind Adolescents (LBA) in China. This study aims to examine if childhood trauma and internet addiction does predict depression on LBA in comparison to Non-Left Behind Adolescents (NLBA) in China. Methods Participants in the study includes a sample of 1890 adolescents aged 12 to 27, including 102 LBA and 1399 NLBA in China. All participants completed the self-report questionnaires, Childhood Trauma Questionnaire (CTQ-28), Internet Addiction Test (IAT), and the Beck Depression Inventory (BDI). Results There was a significant difference in IAT and CTQ between LBA and NLBA (P < 0.05). The frequent childhood trauma type was physical neglect (48%), followed by emotional neglect (32.3%). Males reported higher levels of emotional and physical abuse and physical neglect than female counterparts in LBA. The prevalence of depression (23.5%) and internet addiction (29.4%) were higher among LBA than NLBA. There were no significant differences in depression (p > 0.05). There were positive correlations between CTQ (except emotional neglect), BDI, and IAT. Multiple linear regressions indicated that emotional abuse and neglect, internet addiction, and poor academic performance were significant predictors for depression among LBA. Conclusion Childhood trauma and internet addiction were directly related to symptoms of depression in LBA, There is an urgent need for targeted interventions for LBA to prevent negative mental health outcomes.

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“…Possible reasons might be the mitigating effect of resilience on the potential long-term effects of ACEs, which may shape the mechanisms of benign resilience, a currently unquanti ed resilience that on the one hand mitigates childhood adversity and on the other hand avoids the emergence of risky behaviors in adulthood thereby reducing the risk of infectious diseases [26,42]. Additionally, we found an association between ACEs and amphetamine-type stimulant abuse, and a study in Anhui Province, China, also showed that 44.6% of methamphetamine users reported negative childhood events [43].…”

Section: Discussionmentioning

confidence: 54%

Pathways of effects of adverse childhood experiences on infectious diseases among border drug-use adults: A Structural Equation Modeling

Zhang,

He,

et al. 2023

Preprint

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Background Injection of drug abuse could result in infectious disease, and adverse childhood experiences (ACEs) possibly are associated with infectious disease. However, there is a paucity of literature on a direct or indirect relationship between ACEs, injection of drug use and infectious disease. We thus identified the pathway of influence of ACEs in adulthoods and injection of drug use on infectious disease by structural equation models (SEM). Methods A cross-sectional study was conducted by respondent driving sampling and consecutive sampling among adult drug users in southwest of China in 2021. R software 4.2.1 was used to conduct descriptive, univariate, and SEM analysis. Results There were 404 participants in total, with an average age of 34 and most males (98.3%) and minorities (79.6%). 95.5% of respondents experienced ACEs with 46.6% of reporting 4 or more ACEs. Correlations in SEM showed that infectious disease was directly positively affected by injection of drug use (β = 0.184), and directly negatively affected by ACEs (β=-0.188). Age(β = 0.029), Ethnic(β=-0.021), Education(β = 0.019), Gender(β = 0.022), Sex partners (β=-0.017), and ACEs (β=-0.029) had indirect effects on infectious disease. Conclusions ACEs could be a direct or indirect predictor for infectious disease in adulthood, injection of drug use could be a risk factor and moderate other factors of infection of infectious disease. Strategies for creating a positive home environment, minimizing traumatic or stressful childhood experiences, and increasing awareness of the risks associated with drug injection use are all ways to lower the chance of contracting infectious diseases.

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The relationship between childhood abuse and depression in a sample of Chinese people who use methamphetamine

Cited by 16 publications

References 30 publications

Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

Neurobiology, Clinical Presentation, and Treatment of Methamphetamine Use Disorder

RETRACTED: Childhood trauma and internet addiction predict depression on left behind adolescents

Pathways of effects of adverse childhood experiences on infectious diseases among border drug-use adults: A Structural Equation Modeling

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