Perhaps there is no other research topic like the concept of quality of life (QOL) that has attracted so much research attention from different disciplines. A review of the major databases shows that much research effort has been spent to understand the theoretical and practical aspects of the concept. Using the search term ''QOL'', computer search conducted in July 2004 showed that there were 11 867 citations in PsycINFO, 2 843 citations in Sociological Abstracts, 415 citations in Social Work Abstracts, 4 204 citations in ERIC, 59 932 citations in MEDLINE, and 13 672 citations in CINAHL. Despite the abundance of research in the study of QOL, there are several interesting developments and missing gaps that can be identified in the existing literature. With reference to these developments and missing gaps, several possible research directions can be considered.First, with the growing popularity of ecological models asserting that human behavior is embedded in different ecological systems (e.g., family system and macro socio-cultural system), it is obvious that a more holistic understanding of the concept of QOL and the related phenomena with reference to different systems is called for (Shek, 2003b). Regarding the different systems in which the person is embedded, the family system can be regarded as an important developmental context, particularly in the Asian culture. However, a survey of the literature shows that related QOL research with reference to the family system (e.g., family QOL) is not substantial. In addition, the role of culture (e.g., cultural beliefs) in the development of QOL is far from clear. Finally, despite the growing emphasis on