The relationship between choroidal blood flow and glaucoma progression in a Japanese study population

Kiyota, Naoki; Shiga, Yukihiro; Omodaka, Kazuko; Nakazawa, Toru

doi:10.1007/s10384-022-00929-w

Cited by 5 publications

(3 citation statements)

References 51 publications

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“…In fact, an approximately 12.4% decrease in PR, from 86.1 to 75.4 bpm, would move PR from outside the 25th to 75th percentiles to inside the percentiles for PR for a typical 60-year-old woman [ 41 ], so it is possible that this PR normalization improved local circulation. As we recently showed, there is an association between lower choroidal MBR and faster MD slope [ 20 ]; thus, the link between improved choroidal MBR and an amelioration of VF defect progression in this study was reasonable.…”

Section: Discussionsupporting

confidence: 68%

“…Although the present study population was divided into 2 clusters, it is likely that a larger number of clusters would have been found with a larger population. Third, while choroidal MBR is reportedly not influenced by glaucoma severity, it may be affected by aging [ 20 ]. This makes it challenging to isolate the direct impact of β-blocker eye drops on PR over time.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular BF was assessed with the LSFG-NAVI device (Softcare Co., Ltd., Fukutsu, Japan), which measures MBR in arbitrary units (AU) [ 19 ]. We used parapapillary choroidal MBR as an indicator of choroidal BF to determine the effect of the β-blocker eye drop add-on on ocular BF, because choroidal BF is less affected secondarily to glaucoma severity and is less autoregulated than optic nerve head (ONH)-tissue BF, as we have shown previously [ 20 , 21 ]. To guarantee image quality, only LSFG data with ONH vascular cloud ≥ 0.28 were used [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

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The Effect of β-Blocker Eye Drops on Pulse Rate, Ocular Blood Flow, and Glaucoma Progression: A Retrospective Longitudinal Study

Kiyota,

Shiga,

Ninomiya

et al. 2024

Adv Ther

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Introduction Our study was conducted to determine factors associated with the effectiveness of a β-blocker eye drop add-on in altering pulse rate (PR) in glaucoma patients. Methods This retrospective study examined 236 eyes of 138 patients who received a β-blocker eye drop add-on during follow-up. Patients were included if at least one PR measurement was available both before and after the add-on was started. We collected data on ophthalmic parameters: longitudinal PR; longitudinal choroidal blood flow, represented by laser speckle flowgraphy-measured mean blur rate (MBR); and diacron-reactive oxygen metabolites (d-ROMs). We used a multivariable linear mixed-effects model to investigate the effectiveness of the β-blocker eye drop add-on in altering PR and examined factors contributing to a larger PR alteration after the add-on was started by analyzing the effect on PR of the interaction term between the add-on and clinical factors. We used the k-means method to classify the patients. Results The β-blocker eye drop add-on reduced PR (− 7.61 bpm, P < 0.001). Female gender, higher PR when the add-on was started, lower central corneal thickness, and a higher d-ROM level were associated with greater reduction in PR ( P < 0.05). In a cluster of patients with these clinical features, choroidal MBR increased by + 3.42% when we adjusted for change over time; MD slope, which represents the speed of glaucoma progression, improved by + 0.64 dB/year ( P < 0.05). Conclusions We identified a glaucoma subgroup in which PR decreased, choroidal blood flow increased, and glaucoma progression slowed after a β-blocker eye drop add-on was started. Supplementary Information The online version contains supplementary material available at 10.1007/s12325-023-02762-0.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%