The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease

Lee, Bor‐Jen; Lin, Yi-Chin; Huang, Yann-Chang; Ko, Ya‐Wen; Hsia, Simon; Lin, Ping-Ting

doi:10.1100/2012/792756

Cited by 59 publications

(52 citation statements)

References 29 publications

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“…This solubility means that CoQ can protect lipoproteins and lipids from peroxidation and oxidative damage [8]. CoQ 10 also serves alongside other antioxidants, such as vitamins C and E, to combat free-radical damage arising from energetic mitochondrial reactions [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Cellular factories for coenzyme Q10 production

et al. 2017

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Coenzyme Q10 (CoQ10), a benzoquinone present in most organisms, plays an important role in the electron-transport chain, and its deficiency is associated with various neuropathies and muscular disorders. CoQ10 is the only lipid-soluble antioxidant found in humans, and for this, it is gaining popularity in the cosmetic and healthcare industries. To meet the growing demand for CoQ10, there has been considerable interest in ways to enhance its production, the most effective of which remains microbial fermentation. Previous attempts to increase CoQ10 production to an industrial scale have thus far conformed to the strategies used in typical metabolic engineering endeavors. However, the emergence of new tools in the expanding field of synthetic biology has provided a suite of possibilities that extend beyond the traditional modes of metabolic engineering. In this review, we cover the various strategies currently undertaken to upscale CoQ10 production, and discuss some of the potential novel areas for future research.

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Section: Introductionmentioning

confidence: 99%

Cellular factories for coenzyme Q10 production

et al. 2017

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“…However, some studies have placed in question the effect of SOD activity in CAD [13, 20, 21]. Gupta et al reported that SOD activity decreased with the development of CAD [21].…”

Section: Introductionmentioning

confidence: 99%

Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease

Chang

et al. 2016

BioMed Research International

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Aims. To measure plasma levels of superoxide dismutases 1, 2, and 3 (SOD1, 2, 3) and determine whether SODs can function as biomarkers for coronary artery disease (CAD). Patients & Methods. Patient groups were as follows: patients with stable angina pectoris (SAP, n = 33), patients with acute coronary syndrome (ACS, n = 49), and controls (n = 42). Protein quantification was done using ELISA. Results. The concentrations of plasma SOD1 and SOD2 were higher in CAD than in healthy controls. No difference in SOD3 levels between CAD and control groups was found. Limited correlations were found between SODs and gender, age, and severity of coronary artery stenosis. Conclusions. Plasma levels of SOD1 and SOD2 were elevated in patients with CAD and might serve as surrogate biomarkers for CAD.

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“…за счёт эндогенного синтеза и поступления с пищей. Cтарение и патологические процессы ведут к снижению уровней убихинона в крови и тканях [9][10][11], поэтому CoQ 10 рекомендован для профилактики и в дополнение к традиционной терапии сердечно-сосудистых, неврологических и ряда других заболеваний. Содержащие CoQ 10 препараты и биологически активные добавки предназначены для приёма внутрь, биодоступность CoQ 10 при котором крайне мала [12].…”

Section: Introductionunclassified

HPLC estimation of coenzyme Q10 redox status in plasma after intravenous coenzyme Q10 administration

et al. 2015

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The pharmacokinetics of the total pool of coenzyme Q10 (CoQ10), its oxidized (ubiquinone) and reduced (ubiquinol, CoQ10H2) forms have been investigated in rats plasma during 48 h after a single intravenous injection of a solution of solubilized CoQ10 (10 mg/kg) to rats. Plasma levels of CoQ10 were determined by HPLC with spectrophotometric and coulometric detection. In plasma samples taken during the first minutes after the CoQ10 intravenous injection, the total pool of coenzyme Q10 and proportion of CoQ10H2 remained unchanged during two weeks of storage at -20°C. The kinetic curve of the total pool of coenzyme Q10 corresponds to a one-part model (R2 = 0.9932), while the corresponding curve of its oxidized form fits to the two-part model. During the first minutes after the injection a significant portion of plasma ubiquinone undergoes reduction, and after 7 h the concentration of ubiquinol predominates. The decrease in the total plasma coenzyme Q10 content was accompanied by the gradual increase in plasma ubiquinol, which represented about 90% of total plasma CoQ10 by the end of the first day. The results of this study demonstrate the ability of the organism to transform high concentrations of the oxidized form of CoQ10 into the effective antioxidant (reduced) form and justify prospects of the development of parenteral dosage forms of CoQ10 for the use in the treatment of acute pathological conditions.

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The Relationship between Coenzyme Q10, Oxidative Stress, and Antioxidant Enzymes Activities and Coronary Artery Disease

Cited by 59 publications

References 29 publications

Cellular factories for coenzyme Q10 production

Cellular factories for coenzyme Q10 production

Elevated Levels of Plasma Superoxide Dismutases 1 and 2 in Patients with Coronary Artery Disease

HPLC estimation of coenzyme Q10 redox status in plasma after intravenous coenzyme Q10 administration

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