The Relationship Between Cognitive Function, Depressive Behaviour and Sleep Quality with 24-h Urinary Sodium Excretion in Patients with Essential Hypertension

Afsar, Barış

doi:10.1007/s40292-013-0002-7

Cited by 19 publications

(40 citation statements)

References 21 publications

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“…Contrary to our hypothesis, and to results of some prior studies (5, 6, 19), we did not find that higher sodium intake was associated with poorer cognitive performance. Instead, we found that lower dietary sodium was associated with poorer performance on tests of global (MMSE) and executive (Trails B) cognitive function independent of lifestyle, comorbidities medication use and kidney function.…”

Section: Discussioncontrasting

confidence: 99%

“…Direct comparison of the studies is hampered by methodological differences, and differences in study samples. The study by Afsar (19) examined urine sodium excretion levels in a younger sample of adults in Turkey, recently diagnosed with essential hypertension. Results showed that lower urine sodium excretion levels were associated with higher MMSE scores (19).…”

Section: Discussionmentioning

confidence: 99%

“…In a small cross-sectional study (n=119) of middle-aged to early older-aged adults (average age 54.2 years, maximum 70 years) newly diagnosed with hypertension, higher sodium intake, measured by 24-hour urinary sodium excretion, was associated with poorer cognitive function (19). A large, prospective study of 6,426 women aged 65–79 from the Women’s Health Initiative Memory Study (WHIMS) did not find a significant association between sodium intake, as determined with the Block FFQ, and development of mild cognitive impairment (MCI) or AD over a 9-year follow-up period (6).…”

Section: Introductionmentioning

confidence: 99%

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Association between dietary sodium intake and cognitive function in older adults

Rush

Kritz‐Silverstein

Laughlin

et al. 2017

The Journal of nutrition, health and aging

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OBJECTIVES To examine the association of dietary sodium intake with cognitive function in community-dwelling older adults. DESIGN Cross-sectional study SETTING Southern California community PARTICIPANTS White men (n=373) and women (n=552), aged 50–96 years from the Rancho Bernardo Study, a longitudinal study of cardiovascular disease risk factors and healthy aging. MEASUREMENTS During the 1992–1996 research clinic visit, a food frequency questionnaire was used to determine daily sodium intake; cognitive function was assessed with Trails Making Test, part B (Trails B), Mini-Mental State Exam (MMSE), and Verbal Fluency Test (VFT); and medical, clinical and demographic information was obtained. Linear regression was used to assess the association between calorie-adjusted sodium intake and cognitive test scores with adjustment for demographic, behavioral and health measures. Logistic regression examined the odds of having cognitive impairment by sodium intake. RESULTS Lower sodium intake was associated with poorer performance on Trails B (p=0.008) and MMSE (p=0.003) after controlling for age, sex, and education. Associations did not differ by sex, but there was a significant interaction by age for the Trails B: older (≥80 years), but not younger, adults showed worse performance with lower sodium intake (p=0.03). Associations remained significant after additional adjustment for smoking, alcohol intake, exercise, body weight, cardiovascular risk factors, kidney function, diuretic medication use, and diet quality. Lower daily sodium intake was associated with increased odds of cognitive impairment on the MMSE (score < 26; OR per SD decrease = 1.12, 95% CI 1.08, 1.16). CONCLUSION Lower sodium intake was associated with worse cognitive function in older community-dwelling adults. For the maintenance of cognitive health, older adults may be advised to avoid very low sodium diets.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between dietary sodium intake and cognitive function in older adults

Rush

Kritz‐Silverstein

Laughlin

et al. 2017

The Journal of nutrition, health and aging

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“…Several studies have shown that high-salt diet, which is a common environmental factor in western countries as well as in more and more developing countries, is associated with cognitive decline [3,4,5]. Moreover, high-salt diet impairs cognitive function in mouse models [6].…”

Section: Discussionmentioning

confidence: 99%

“…Several independent epidemiological investigations have shown that high-salt diet is associated with cognitive decline in human [3,4,5]. Recently, it’s found that high-salt diet could impair cognitive function in wild-type mice [6].…”

Section: Introductionmentioning

confidence: 99%

Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells

et al. 2015

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Recent studies suggest that high-salt diet is associated with cognitive decline in human and mouse. The fact that genetic factors account for less than 50% cases of sporadic Alzheimer’s disease (AD) highlights the important contribution of environmental factors, such as high-salt diet, in AD pathogenesis. However, whether and how high-salt diet fits the “amyloid cascade” hypothesis remains unexplored. Here, we show sodium chloride (NaCl) could increase Aβ levels in the medium of HEK293 cells overexpressing amyloid precursor protein (APP) or C99 fragment. NaCl treatment dose not affect APP level, gamma secretase level or activity. Instead, NaCl treatment suppresses the capacity of cells to clear Aβ and reduces Apolipoprotein E (ApoE) level. Finally, NaCl treated THP-1 or BV2 cells are inefficient in clearing Aβ when co-cultured with rat primary neurons. Our study suggests that high-salt diet may increase AD risk by directly modulating Aβ levels.

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Salt Intake and Cognitive Function

Rossi

Strazzullo

2013

High Blood Press Cardiovasc Prev

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The Relationship Between Cognitive Function, Depressive Behaviour and Sleep Quality with 24-h Urinary Sodium Excretion in Patients with Essential Hypertension

Cited by 19 publications

References 21 publications

Association between dietary sodium intake and cognitive function in older adults

Association between dietary sodium intake and cognitive function in older adults

Sodium Chloride Increases Aβ Levels by Suppressing Aβ Clearance in Cultured Cells

Salt Intake and Cognitive Function

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