The relationship between compensatory hyperplasia of the myodural bridge complex and reduced compliance of the various structures within the cranio‐cervical junction

Song, Xue; Gong, Jin; Yu, Sheng-Bo; Yang, Heng; Song, Yang; Zhang, Xuhui; Zhang, Jing; Hack, Gary D.; Li, Tai-Lai; Chi, Yan-Yan; Zheng, Nan; Sui, Hong-Jin

doi:10.1002/ar.25040

Cited by 12 publications

(8 citation statements)

References 38 publications

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“…It has been reported in our previous study that hyperplastic changes of the MDBC in this model resulted in increased stiffness of the SDM and reduced compliance of various structures within the cranio-cervical junction 21 . In a hypothesis study about the pathophysiology of symptomatic adult Chiari malformation Type I, it was mentioned that the stiff dura may limit the natural expansion of the subarachnoid space, thereby changing the pressure environment of CSF flow 22 .…”

Section: Discussionsupporting

confidence: 49%

“…In our previous animal study, according to the fibrogenic effect of bleomycin, we found that injection of bleomycin into the posterior atlanto-occipital interspace of rats led to proliferative changes in the MDBC fibers and an increased sectional area of the RCDmi, as demonstrated by histological and semi-quantitative studies 21 . Thus, the same methods were used in the present study and yielded consistent results.…”

Section: Discussionmentioning

confidence: 69%

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Evidence for chronic headaches induced by pathological changes of myodural bridge complex

Song,

Yu,

Yuan

et al. 2024

Sci Rep

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Clinical studies have shown that there may be a certain relationship between pathological changes of the myodural bridge complex (MDBC) and chronic headaches of unknown cause. But there is still a lack of experimental evidence to explain the possible mechanism. This study aims to further confirm this relationship between MDBC and chronic headaches and explore its potential occurrence mechanism in rats. Bleomycin (BLM) or phosphate-buffered saline (PBS) was injected into the myodural bridge fibers of rats to establish the hyperplastic model of MDBC. After 4 weeks, the occurrence of headaches in rats was evaluated through behavioral scores. The immunohistochemistry staining method was applied to observe the expression levels of headache-related neurotransmitters in the brain. Masson trichrome staining results showed that the number of collagen fibers of MDBC was increased in the BLM group compared to those of the other two groups. It revealed hyperplastic changes of MDBC. The behavioral scores of the BLM group were significantly higher than those of the PBS group and the blank control group. Meanwhile, expression levels of CGRP and 5-HT in the headache-related nuclei of the brain were increased in the BLM group. The current study further confirms the view that there is a relationship between pathological changes of MDBC and chronic headaches of unknown cause. This study may provide anatomical and physiological explanations for the pathogenesis of some chronic headaches of unknown cause.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 69%

Evidence for chronic headaches induced by pathological changes of myodural bridge complex

Song,

Yu,

Yuan

et al. 2024

Sci Rep

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“…In these experiments, surgical disruption of the myodural bridge increased the bulk flow of CSF out of the spinal compartment (presumably by dilating the rostral portion of the spinal dura) and increased the propagation time of the secondary pulsations (presumably by creating localized turbulence at the foramen magnum). A recent contribution [35] examined how pathological conditions within the myodural bridge could alter compliance of structures around the foramen magnum in mice. Our conclusion is similar, but we would argue that the relationship between the myodural bridge, dural compliance, and CSF pressure is a regular part of the CSF dynamics influencing the flow and pressure of the CSF in both the healthy and pathological states.…”

Section: Discussionmentioning

confidence: 99%

Dynamic asymmetry in cerebrospinal fluid pressure: An indicator of regional differences in compliance

English¹,

Taylor²,

Cramberg³

et al. 2023

Surgical Neurology International

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Background: Dural compliance influences the shape and magnitude of the cerebrospinal fluid (CSF) pulsations. In humans, cranial compliance is approximately 2× greater than spinal compliance; the differential has been attributed to the associated vasculature. In alligators, the spinal cord is surrounded by a large venous sinus, which suggests that the spinal compartment may have higher compliance than is found in mammals. Methods: Pressure catheters were surgically implanted into the cranial and spinal subdural spaces of eight subadult American alligators (Alligator mississippiensis). The CSF was propelled through the subdural space by orthostatic gradients and rapid changes in linear acceleration. Results: CSF pressure recordings taken from the cranial compartment were consistently, and significantly, larger than those taken from the spinal compartment. After the myodural bridge of Alligator was surgically released, the asymmetry in CSF pressure was decreased. Conclusion: Unlike the situation in humans, the spinal compartment of Alligator has greater compliance than the cranial compartment, presumably due to the presence of the large spinal venous sinus surrounding the dura. The change in CSF pressures after myodural surgical release supports the hypothesis that the myodural bridge functions, at least in part, to modulate dural compliance and the exchange of CSF between the cranial and spinal compartments.

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“…[ 34 ] Some scholars thought that MDBC could modulate the compliance of SDM. [ 35 , 36 ] The SDM is attached to the periphery of the foramen magnum and the internal aspects of the posterior C1 and C2 vertebral bodies, and to the coccyx through the filum terminale. The SDM also invests on the spinal nerve roots as far as the level of the intervertebral foramen.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of craniosacral therapy in the human suboccipital region on hamstring muscle: A meta-analysis based on current evidence

Jiang

Samuel

et al. 2023

Medicine

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Background: Craniosacral therapy (CST) has remained controversial in the treatment of musculoskeletal disorders. To our knowledge, there is no larger sample size of research to demonstrate the effectiveness of craniosacral therapy in the human suboccipital region on hamstring muscle. Methods: To study whether the CST in the human suboccipital region could have a remote effect on the flexibility of the hamstring muscles, the Cochrane Library, Medline/Pubmed, CNKI, Embase, and Google Scholar were searched. Clinical trials assessing the effects of CST in short hamstring syndrome patients were eligible. Mean differences (MD) and 95% confidence intervals (CI) were calculated for the straight leg raise test (primary outcomes). The quality of the included studies was assessed using the Newcastle-Ottawa Scale. RevMan 5.3 software was used for data analysis. Results: Five controlled trials with a total of 238 participants were included. CST could effectively relieve the symptoms of short hamstring syndrome patients [the overall MD −9.47, 95% confidence interval (CI) −15.82 to −3.12, P < .000001]. The CST was better than the proprioceptive neuromuscular facilitation technique (MD 3.09, 95% CI 1.48–4.70, P = .0002). Sensitivity analysis shows that the frequency of treatment and who did the experiment might be the main sources of impact results. Conclusion: CST could change the flexibility of the hamstring muscles. CST had a better curative effect when compared to proprioceptive neuromuscular facilitation technique on the hamstring muscles.

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The relationship between compensatory hyperplasia of the myodural bridge complex and reduced compliance of the various structures within the cranio‐cervical junction

Cited by 12 publications

References 38 publications

Evidence for chronic headaches induced by pathological changes of myodural bridge complex

Evidence for chronic headaches induced by pathological changes of myodural bridge complex

Dynamic asymmetry in cerebrospinal fluid pressure: An indicator of regional differences in compliance

Effectiveness of craniosacral therapy in the human suboccipital region on hamstring muscle: A meta-analysis based on current evidence

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