The Relationship between Controlling Nutritional (CONUT) Score and Clinical Markers among Adults with Hepatitis C Virus Related Liver Cirrhosis

Nishikawa, Hiroki; Enomoto, Hirayuki; Ishii, Noriko; Iwata, Yoshinori; Takata, Ryo; Nishimura, Takashi; Aizawa, Nobuhiro; Sakai, Yoshiyuki; Ikeda, Naoto; Hasegawa, Kunihiro; Takashima, Tomoyuki; Iijima, Hiroko; Nishiguchi, Shuhei

doi:10.3390/nu10091185

Cited by 17 publications

(8 citation statements)

References 34 publications

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“…The correlation between CONUT score and CTP score was higher than that between CONUT and MELD score, which was similar to the conclusions obtained by previous studies [22]. A number of retrospective studies on patients with hepatitis C cirrhosis have shown that the CONUT score can re ect the liver reserve function, the larger the CONUT score value, the larger the CTP score, the worse the liver function [23,24];An inverse association between CONUT score and liver function was similarly con rmed in a single-center cross-sectional study of 126 patients with liver cirrhosis in Spain [25]. In this study, the CTP score and MELD score of the high CONUT group were signi cantly higher than those of the low CONUT group, and the liver reserve function was signi cantly worse in the high CONUT group.…”

Section: Discussionsupporting

confidence: 88%

CONUT score to evaluate the prognosis of patients with cirrhosis complicated with esophageal and gastric variceal bleeding after initial endoscopic treatment

cai

Liu

Cheng

et al. 2023

Preprint

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Objective: The nutritional status of patients with liver cirrhosis complicated with EGVB controlled with initial endoscopic treatment in our hospital was evaluated according to the CONUT score. We compared the clinical data and prognosis of patients with different levels of nutritional status, and then investigated the role of CONUT score before endoscopic treatment on its prognosis. Methods: This is a retrospective study and obtain informed consent from all the study participants by telephone and wetchat.The patients diagnosed with liver cirrhosis complicated with Esophageal and gastric variceal bleeding (EGVB) in our hospital from April 2018 to November 2018 were retrospectively selected, and then controlled successfully by endoscopic operation. A total of 166 patients were included in this study. Patients were divided into two groups: the low CONUT score group and the high CONUT score group, based on the optimal cut-off points determined using receiver operating characteristic (ROC) analysis. The differences in baseline data, endoscopic data, treatment effects, and survival analysis were compared between the two groups of patients. Conclusion COUNT score affects prognosis of patients with EGVB.

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Section: Discussionsupporting

confidence: 88%

CONUT score to evaluate the prognosis of patients with cirrhosis complicated with esophageal and gastric variceal bleeding after initial endoscopic treatment

cai

Liu

Cheng

et al. 2023

Preprint

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“…As well known, ESLD causes a reduction in the biosynthetic activity of the liver, translating into lower levels of circulating proteins such as albumin and apolipoproteins. Consequently, the CONUT score reflects the actual liver functional reserve, being particularly useful in the specific setting of patients with more advanced liver disease (34). As a confirmation of this datum, we observed higher CONUT values and lower median levels of cholesterol and albumin in the high CCI group, namely the group comprising more advanced ESLD cases.…”

Section: Discussionsupporting

confidence: 80%

CONUT Score Predicts Early Morbidity After Liver Transplantation: A Collaborative Study

et al. 2022

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Introduction: Liver transplantation (LT) is burdened by the risk of post-operative morbidity. Identifying patients at higher risk of developing complications can help allocate resources in the perioperative phase. Controlling Nutritional Status (CONUT) score, based on lymphocyte count, serum albumin, and cholesterol levels, has been applied to various surgical specialties, proving reliable in predicting complications and prognosis. Our study aims to investigate the role of the CONUT score in predicting the development of early complications (within 90 days) after LT.Methods: This is a retrospective analysis of 209 patients with a calculable CONUT score within 2 months before LT. The ability of the CONUT score to predict severe complications, defined as a Comprehensive Complication Index (CCI) ≥42.1, was examined. Inverse Probability Treatment Weighting was used to balance the study population against potential confounders.Results: Patients with a CCI ≥42.1 had higher CONUT score values (median: 7 vs. 5, P-value < 0.0001). The CONUT score showed a good diagnostic ability regarding post-LT morbidity, with an AUC = 0.72 (95.0%CI = 0.64–0.79; P-value < 0.0001). The CONUT score was the only independent risk factor identified for a complicated post-LT course, with an odds ratio = 1.39 (P-value < 0.0001). The 90-day survival rate was 98.8% and 87.5% for patients with a CONUT score <8 and ≥8, respectively.Conclusions: Pre-operative CONUT score is a helpful tool to identify patients at increased post-LT morbidity risk. Further refinements in the score composition, specific to the LT population, could be obtained with prospective studies.

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“…Some authors have reported that certain objective assessment indexes reflecting the immune-nutritional status of patients, such as the prognostic nutritional index (PNI) [16], the controlling nutritional status (CONUT) score [17], and the nutritional risk index (NRI) [18,19], which are calculated using serum albumin level and lymphocyte count, represent useful screening tools for patient prognosis in several diseases [20,21,22,23,24,25]. PNI was at first described as a simple and objective indicator of postoperative outcomes in patients undergoing cancer surgery [16,26].…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Nutritional Index and Nutritional Risk Index Are Associated with Disease Activity in Patients with Systemic Lupus Erythematosus

et al. 2019

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The prognostic nutritional index (PNI), controlling nutritional status (CONUT) score and nutritional risk index (NRI) have been described as useful screening tools for patient prognosis in several diseases. The aim of this study was to examine the relationship between PNI, CONUT and NRI with clinical disease activity and damage in 173 patients with systemic lupus erythematous (SLE). Disease activity was assessed with the SLE disease activity index (SLEDAI-2K), and disease-related organ damage was assessed using the SLICC/ACR damage index (SDI) damage index. PNI and NRI were significantly lower in active SLE patients than in inactive SLE patients (p < 0.001 and p = 0.012, respectively). PNI was inversely correlated with the SLEDAI score (p < 0.001) and NRI positively correlated with SLEDAI and SDI scores (p = 0.027 and p < 0.001). Linear regression analysis adjusting for age, sex and medications showed that PNI was inversely correlated with SLEDAI (β (95% CI) = −0.176 (−0.254, −0.098), p < 0.001) and NRI positively correlated with SLEDAI (β (95% CI) = 0.056 (0.019, 0.093), p = 0.003) and SDI (β (95% CI) = 0.047 (0.031, 0.063), p < 0.001). PNI (odds ratio (OR) 0.884, 95% confidence interval (CI) 0.809–0.967, p = 0.007) and NRI ((OR) 1.067, 95% CI 1.028–1.108, p = 0.001) were independent predictors of active SLE. These findings suggest that PNI and NRI may be useful markers to identify active SLE in clinical practice.

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The Relationship between Controlling Nutritional (CONUT) Score and Clinical Markers among Adults with Hepatitis C Virus Related Liver Cirrhosis

Cited by 17 publications

References 34 publications

CONUT score to evaluate the prognosis of patients with cirrhosis complicated with esophageal and gastric variceal bleeding after initial endoscopic treatment

CONUT score to evaluate the prognosis of patients with cirrhosis complicated with esophageal and gastric variceal bleeding after initial endoscopic treatment

CONUT Score Predicts Early Morbidity After Liver Transplantation: A Collaborative Study

The Prognostic Nutritional Index and Nutritional Risk Index Are Associated with Disease Activity in Patients with Systemic Lupus Erythematosus

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