The coronavirus COVID-19 pandemic is an unprecedented health crisis. Many governments around the world have responded by implementing lockdown measures of different degrees of intensity. To be effective, such measures must rely on citizens’ compliance and collaboration. In the present study (N = 1896), we examined predictors of compliance with social distancing norms, and intentions to disclose the disease to authorities and acquaintances/friends, in the US, Italy and South Korea. We investigated the role of cultural orientations of horizontal and vertical individualism and collectivism, trust in the government’s action, and self-conscious emotions of shame and guilt related to the disease. Across countries, vertical collectivism predicted stronger shame whereas horizontal collectivism predicted stronger trust in the government’s action. Only in the US, vertical collectivism was associated with stronger trust. Subsequently, shame predicted lower compliance and intentions to disclose the disease, guilt was associated with stronger intentions to disclose the disease to the authorities, and trust was associated with stronger compliance and intentions to disclose the disease to authorities. Unlike Italy and South Korea, the association between trust on compliance was not statistically significant in the US, Implications of the findings, and directions for future research are discussed.