The Relationship between Dialysis Metrics and Patient-Reported Cognition, Fatigue, and Physical Function

Sturgill, Daniel; Bal, Naveet; Nagavally, Sneha; Wolfgram, Dawn

doi:10.1159/000508919

Cited by 8 publications

(6 citation statements)

References 28 publications

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“…Patients on hemodialysis with comorbidities often experience fatigue, and a positive correlation between exercising for less than 1 h daily and fatigue was identified [ 56 ]. However, few studies have explored whether Kt/V scores and anxiety are correlated [ 57 ]. Hornik et al [ 58 ] reported that relative to patients on hemodialysis who engaged in a low level of physical activity on an irregular basis, those who engaged in a high level of physical activity on a regular basis have a lower comorbidity rate; their study also posited that regular physical activity improves the effect of hemodialysis on patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Physical Activity and Psychological Distress in Patients Receiving Hemodialysis with Comorbidities: A Cross-Sectional Study

Hsu

Tzeng

2022

IJERPH

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Comorbidities cause psychological distress to patients on hemodialysis and cause their physical function to deteriorate. This study aims to examine whether physical patterns are associated with anxiety, depression and fatigue among patients with and without comorbidities who are on hemodialysis. To this end, a cross-sectional survey was administered to 120 patients on hemodialysis. Data were collected using the International Physical Activity Questionnaire—Short Form, Beck Depression Inventory—Second Edition, Beck Anxiety Inventory, and Brief Fatigue Inventory—Taiwan Version. An independent sample t test and generalized linear model analyses were conducted. The results revealed that patients with comorbidities exhibited more severe levels of depression (p < 0.001), anxiety (p < 0.001), and fatigue (p = 0.010) than patients without comorbidities. Additionally, patients on hemodialysis with a high physical activity level (≥600 metabolic equivalent of task per min/week) exhibited less depression (B = −4.03; p < 0.001; 95% confidence interval [CI] = −6.04, −2.03) and anxiety (B = −2.64; p = 0.002; 95% CI = −4.27, −1.00) severity than those with a low physical activity level; those who engaged in weekly physical activities exhibited less fatigue severity (B = −1.17; p = 0.001; 95% CI = −1.84, −0.49) and fatigue interference (B = −0.61; p = 0.015; 95% CI = −1.10, −0.12). For patients on hemodialysis, having comorbidities was correlated with more severe levels of depression, anxiety, and fatigue. Weekly moderate-intensity physical activities were revealed to be correlated with less severity levels of depression, anxiety, and fatigue. The study findings aid the development of interventions for promoting physical activity among patients on hemodialysis to prevent the exacerbation of complications caused by comorbidities and psychological distress.

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Section: Discussionmentioning

confidence: 99%

Correlation between Physical Activity and Psychological Distress in Patients Receiving Hemodialysis with Comorbidities: A Cross-Sectional Study

Hsu

Tzeng

2022

IJERPH

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“…Various studies have shown a relationship between PDF and sociodemographic factors such as age, gender and employment status; medical problems such as anaemia, malnutrition, sleep disorders and secondary hyperparathyroidism; changes in clinical variables such as albumin, Kt/V and the urea reduction rate; and psychological conditions such as anxiety, stress and depression 7,11,12 …”

Section: Introductionmentioning

confidence: 99%

“…10 Various studies have shown a relationship between PDF and sociodemographic factors such as age, gender and employment status; medical problems such as anaemia, malnutrition, sleep disorders and secondary hyperparathyroidism; changes in clinical variables such as albumin, Kt/V and the urea reduction rate; and psychological conditions such as anxiety, stress and depression. 7,11,12 There is no consensus decision or a specific diagnostic tool with proven validity and reliability as regards defining PDF and its severity. 5,9 Although the vitality subdimension of the SF-36 QoL Scale and the Visual analogue scale (VAS) are frequently used in the relevant studies, 5,13 it is not possible to define the severity and incidence of PDF.…”

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confidence: 99%

The reliability and validity of the Turkish version of the postdialysis fatigue scale

et al. 2021

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Aim Haemodialysis (HD) commonly leads to postdialysis fatigue (PDF) and, thus, worsens the quality of life and the clinical outcomes. The aim of this study was to translate, linguistically validate and determine the psychometric properties of the “Postdialysis Fatigue” Scale for Turkish patients with HD. Study Design A methodological study. Methods The standard lingual translation and validation methods for the initial translation of the PDF Scale and then assessed the psychometric properties of reliability and validity of the translated scale. Visual analogue scale (VAS) and Piper Fatigue Scale were used to assess concurrent and construct validity. In addition, postdialysis recovery time was used it as an indirect measurement method for PDF. Results A total of 93 patients participated in the study. The Cronbach's alpha coefficient of PDF was 0.773. There was a statistically significant relationship between the test and retest scores (ICC: 0.973; P < .001). PDF Scale was acceptable with 11 items. There was a positive correlation with a statistically significant relationship was present between the PDF scores and Piper Fatigue Scale (r = .488; P < .001) and VAS score (r = .656; P < .001). There was a statistically significant positive correlation between the PDF Scale and the postdialysis recovery time (r = .270; P = .009), Conclusion The study results have shown that the Turkish form of the PDF Scale is a valid and reliable tool in patients undergoing HD treatment. Postdialysis recovery time may be used as an indirect measurement method to evaluate PDF.

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“…Further, PROMIS domains demonstrated greater reliability over a broader range of symptom severity or functional impairment compared with SF-12 or SF-36 (31,32). The precise, versatile PROMIS item banks (administered either as four-or eight-item short forms, or computer adaptive test) have also already been used as outcome measures studies (33,34) and in clinical practice for symptom monitoring (35)(36)(37). In addition, PROPr, and the overall mental and physical health summary scores (38), provide reliable measures of health utility and overall HRQOL.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of PROMIS Preference Scoring System (PROPr) in Patients Undergoing Hemodialysis or Kidney Transplant

Dewitt

Tang

Breitner

et al. 2021

CJASN

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Background and Objectives A preference-based health utility score (PROPr) can be calculated using Patient-Reported Outcomes Measurement Information System domain scores. We assessed the construct validity of PROPr among patients treated with kidney replacement therapy (hemodialysis or kidney transplant). Design, setting, participants and measurements Secondary analysis of data collected in multicenter, cross-sectional studies of adults treated with kidney replacement therapy, recruited between April 2016 to March 2020 in Toronto, Canada. All participants provided informed consent. The outcome was PROPr score. Co-administered outcome variables included the Short form 6-domain (SF-6D) and EuroQol 5-domain 5-level (EQ-5D-5L) scores. Socioeconomic and clinical variables included age, sex, diabetes, estimated Glomerular Filtration Rate (eGFR), serum albumin, hemoglobin, kidney replacement therapy and Charlson-comorbidity index. Construct validity was assessed through correlations between PROPr and SF-6D or EQ-5D-5L and associations between PROPr and other exposure variables. Health condition impact estimates (coefficients for health conditions compared to a referent category: e.g. dialysis vs kidney transplant) were calculated using multivariable linear regression. Results Mean (SD) age of the 524 participants was 57 (17) years, 58% were male and 45% white. Median (IQR) score was 0.39 (0.24-0.58) for PROPr, 0.69 (0.58-0.86) for SF-6D and 0.85 (0.70-0.91) for EQ-5D-5L. Large correlations were observed between PROPr vs SF-6D (0.79, 95%CI: 0.76 - 0.82) and EQ-5D-5L (0.71, 95%CI: 0.66 - 0.75). Both PROPr and the other utility indices demonstrated health condition impact in the expected direction. For example, the estimate for PROPr was -0.17 (95%CI: -0.13, -0.21) for dialysis (versus kidney transplant), -0.05 (95%CI: -0.11, 0.01, P=0.08) for kidney transplant recipients with eGFR <45 vs ≥45 ml/min/1.73m2 and -0.28 (95%CI: -0.22, -0.33) for moderate/severe versus no/mild depressive symptoms. Conclusions Our results support the validity of PROPr among patients treated with kidney replacement therapy.

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The Relationship between Dialysis Metrics and Patient-Reported Cognition, Fatigue, and Physical Function

Cited by 8 publications

References 28 publications

Correlation between Physical Activity and Psychological Distress in Patients Receiving Hemodialysis with Comorbidities: A Cross-Sectional Study

Correlation between Physical Activity and Psychological Distress in Patients Receiving Hemodialysis with Comorbidities: A Cross-Sectional Study

The reliability and validity of the Turkish version of the postdialysis fatigue scale

Evaluation of PROMIS Preference Scoring System (PROPr) in Patients Undergoing Hemodialysis or Kidney Transplant

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