The relationship between different C-peptide level and insulin dose of insulin pump

Wei, Yihan; Quan, Li; Zhou, Ting; Du, Guoli; Jiang, Sheng

doi:10.1038/s41387-020-00148-7

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Patients with LADA have low C‐peptide levels and show slower progression in islet cell destruction than those with type 1 diabetes mellitus 22 . C‐peptide is a marker secreted by islet β‐cells, and is not affected by exogenous insulin, which can reflect insulin content in the body and residual function of islet β‐cells 23 . Therefore, it is crucial for LADA patients to improve glycemic control and preserve β‐cell function.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta‐analysis

Lin

Cai

Tang

et al. 2022

J of Diabetes Invest

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Aims/Introduction The optimal therapy for latent autoimmune diabetes in adults (LADA) remains undefined. Increasing evidence has shown that sitagliptin and insulin treatment can benefit patients with LADA, but the efficacy still lacks systematic evaluation. We carried out this systematic review and meta‐analysis to summarize the current data on the efficacy and safety of sitagliptin combined with insulin on LADA, providing a reliable reference for the effective therapeutic treatment of LADA patients. Materials and Methods We retrieved the literature in PubMed, Cochrane Library, Embase, Web of Science and CNKI from inception to August 2021. Randomized controlled trials comparing the effects of sitagliptin plus insulin with insulin alone in LADA patients were identified. The outcome measures included parameters of glycemic control, β‐cell function, body mass index and adverse events. The Review Manager 5.2 and Stata 14.0 were utilized for data analysis. Results Eight randomized controlled trials involving 295 participants were identified. Sitagliptin and insulin treatment lowered hemoglobin A1c (weighted mean difference −0.36, 95% confidence interval −0.61 to −0.10, I 2 = 91.6%), increased fasting C‐peptide (weighted mean difference 0.08, 95% confidence interval −0.02 to 0.17, I 2 = 88.8%) and had fewer adverse events compared with insulin alone. The inter‐study heterogeneity, potential publication bias and other factors might interpret asymmetrical presentation of funnel plots. There was no significant association between sitagliptin plus insulin treatment and levels of hemoglobin A1c or fasting C‐peptide, regardless of the duration of intervention and sample size. Conclusions Sitagliptin combined with insulin can achieve better glycemic control and improve islet β‐cell function with lower incidence of hypoglycemia compared with insulin alone, which provides an effective and tolerated therapeutic regimen for LADA patients. However, further well‐designed and rigorous randomized controlled trials are required to validate this benefit due to the limited methodology quality of included trials.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta‐analysis

Lin

Cai

Tang

et al. 2022

J of Diabetes Invest

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“…Circular dichroism studies showed that all four binders were largely helical as designed and thermostable up to 95 °C (Supplementary Fig. 1b) C-peptide is a 31 residue peptide secreted by islet β cells that is made from the same precursorproinsulin -as insulin 24 . Measurement of plasma C-peptide levels is important for accurate classification and diagnosis of type I and type II diabetes 25 .…”

Section: Mainmentioning

confidence: 99%

Diffusing protein binders to intrinsically disordered proteins

Liu,

Wu,

Choi

et al. 2024

Preprint

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Proteins which bind intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) with high affinity and specificity could have considerable utility for therapeutic and diagnostic applications. However, a general methodology for targeting IDPs/IDRs has yet to be developed. Here, we show that starting only from the target sequence of the input, and freely sampling both target and binding protein conformation, RFdiffusion can generate binders to IDPs and IDRs in a wide range of conformations. We use this approach to generate binders to the IDPs Amylin, C-peptide and VP48 in a range of conformations with Kds in the 3 -100nM range. The Amylin binder inhibits amyloid fibril formation and dissociates existing fibers, and enables enrichment of amylin for mass spectrometry-based detection. For the IDRs G3bp1, common gamma chain (IL2RG) and prion, we diffused binders to beta strand conformations of the targets, obtaining 10 to 100 nM affinity. The IL2RG binder colocalizes with the receptor in cells, enabling new approaches to modulating IL2 signaling. Our approach should be widely useful for creating binders to flexible IDPs/IDRs spanning a wide range of intrinsic conformational preferences.

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“…C peptide is a polypeptide comprising 31 amino acids with a molecular weight of 3600. C-peptide is cleaved from pro-insulin, retained in secretory granules, and subsequently released into the bloodstream in levels equal to those of insulin during insulin biosynthesis 5 . The development of inter-chain disulfide bonds and accurate folding are both dependent on the presence of C-peptide, which fulfils an important role in the process of insulin manufacturing by acting as a connection between the A and B chains 6 .…”

Section: Introductionmentioning

confidence: 99%

Association between Serum C-peptide Level and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients on Oral Anti-diabetic Drug

Das,

Tasnim,

Islam

2023

Bangladesh J Med Sci

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Background: Diabetic Nephropathy (DN) treatment focuses mostly on preventing or delaying disease development. The most recent research indicates that C-peptide may have a favourable biological effect on DN. In type 2 Diabetes Mellitus, the link between C-peptide level and DN is poorly understood (DM). The purpose of this study is to evaluate the relation between serum C-peptide and diabetic nephropathy in type 2 DM patients taking an oral anti diabetic medication. Methods: From July 2019 to June 2020, a cross-sectional observational study was done at the Department of Pharmacology and Therapeutics at Dhaka Medical College, Dhaka. A total of 63 randomly selected type 2 diabetes patients met the inclusion criteria. SPSS was used to collect, record, and evaluate biochemical values including FBG, 2hrs ABF, HbA1c, urine for microalbumin, serum creatinine, and serum C-peptide. Result: Among 63 study participants, 40 (63.5%) were female and 23 (36.5%) were male. Mean age of patients was 50.30±10.55 years. Mean duration of DM of total study subjects was 6.29±3.15 years. Out of total study subjects, 17.5% (11) had low serum C-peptide, 74.6% (47) had normal serum C-peptide and 7.9% (5) had high serum C-peptide level. Correlations of clinical and biochemical variables showed negative correlation between serum C-peptide level and microalbumin, DM duration, FBS, 2hrs ABF, HbA1c, creatinine. Mean urine albumin was higher in patients with low serum C-peptide level. The microalbumin level and the duration of DM of study subjects are significantly associated with serum C-peptide. Conclusion: In this study we have found that type 2 diabetic individuals with low serum C-peptide levels have a high frequency of diabetic nephropathy and that serum C-peptide levels are significantly associated with diabetic nephropathy. Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 768-772

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The relationship between different C-peptide level and insulin dose of insulin pump

Cited by 4 publications

References 17 publications

Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta‐analysis

Efficacy and safety of sitagliptin and insulin for latent autoimmune diabetes in adults: A systematic review and meta‐analysis

Diffusing protein binders to intrinsically disordered proteins

Association between Serum C-peptide Level and Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients on Oral Anti-diabetic Drug

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