The relationship between elevated serum uric acid and arterial stiffness in a healthy population

Jiang, Ye; Ge, Jianli; Zhang, Yuyan; Wang, Fangfang; Ji, Yuan; Li, Haiyan

doi:10.1177/1708538120913721

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…In addition, gout nephropathy, a form of chronic tubulointerstitial nephritis, induced by the deposition of urate precipitates in the distal collecting ducts and the medullary interstitium may cause progressive chronic kidney disease [4]. Furthermore, gout and hyperuricemia have been associated with a subset of comorbidities including metabolic syndrome, diabetes, hypertension as well as cardiovascular and cerebrovascular disease [5][6][7][8][9][10][11][12][13]. In most patients, the onset of gout occurs after the age of 60, with the incidence being about three times higher in men than in women [14].…”

Section: Introductionmentioning

confidence: 99%

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

Eckenstaler

Benndorf

2021

IJMS

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Urate homeostasis in humans is a complex and highly heritable process that involves i.e., metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate excretion. Importantly, disturbances in urate excretion are a common cause of hyperuricemia and gout. The majority of urate is eliminated by glomerular filtration in the kidney followed by an, as yet, not fully elucidated interplay of multiple transporters involved in the reabsorption or excretion of urate in the succeeding segments of the nephron. In this context, genome-wide association studies and subsequent functional analyses have identified the ATP-binding cassette (ABC) transporter ABCG2 as an important urate transporter and have highlighted the role of single nucleotide polymorphisms (SNPs) in the pathogenesis of reduced cellular urate efflux, hyperuricemia, and early-onset gout. Recent publications also suggest that ABCG2 is particularly involved in intestinal urate elimination and thus may represent an interesting new target for pharmacotherapeutic intervention in hyperuricemia and gout. In this review, we specifically address the involvement of ABCG2 in renal and extrarenal urate elimination. In addition, we will shed light on newly identified polymorphisms in ABCG2 associated with early-onset gout.

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Section: Introductionmentioning

confidence: 99%

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

Eckenstaler

Benndorf

2021

IJMS

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“…Few studies in the literature have investigated orthostatic BP changes with uric acid. In one study, Jiang et al found no relationship between serum uric acid levels and arterial stiffness causing OH development [16]. In another study, he found that association of high serum uric acid and increased arterial stiffness was dependent on cardiovascular risk factors in female population [17].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Orthostatic Hypotension in Patients with Diabetic Nephropathy

Aytaş

Kazancıoğlu

Elçioğlu

et al. 2021

Kidney Blood Press Res

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Introduction: Orthostatic hypotension (OH) affects 5–20% of the population. Our study investigates the presence of OH in diabetic nephropathy (DNP) patients and the factors affecting OH in comparison with nondiabetic chronic kidney disease (NDCKD) patients. Method: Patients presented to the nephrology clinic, and those who consented were included in the study. DNP was defined by kidney biopsy and/or clinical criteria. NDCKD patients of the same sex, age, and eGFR were matched to DNP patients. Demographic parameters and medications were obtained from the records. OH was determined by Mayo clinic criteria. The same researcher used an electronic device to measure blood pressure (BP). All samples were taken and analyzed the same day for biochemical and hematologic parameters and albuminuria. Results: 112 (51 F, 61 M, mean age: 62.56 ± 9.35 years) DNP and 94 (40 F, 54 M, mean age: 62.23 ± 10.08 years) NDCKD patients were included. There was no significant difference between DNP and NDCKD groups in terms of OH prevalence (70.5 vs. 61.7%, p = 0.181). Male patients had significantly higher OH prevalence than female patients (74.7 vs. 60.0%, p = 0.026). There was no significant difference in change in systolic BP between the groups (24.00 [10.00–32.00] mm Hg vs. 24.00 [13.75–30.25] mm Hg, p = 0.797), but the change in diastolic BP was significantly higher in the DNP group (8.00 [2.00–13.00] mm Hg vs. 6.00 [2.00–9.00] mm Hg, p = 0.025). In the DNP group, patients with OH had significantly higher uric acid levels than those without OH (7.18 ± 1.55 vs. 6.36 ± 1.65 mg/dL, p = 0.017). And, 73.7% of patients on calcium channel blockers developed OH (p = 0.015), and OH developed in 80.6% of 36 patients on alpha-blockers (p = 0.049). Conclusion: OH prevalence is very high in CKD, and etiology of CKD does not have a statistically significant effect on the frequency of OH, despite a difference that could be meaningful clinically. Therefore, patients with CKD are checked for OH, with or without concurrent diabetes mellitus. Evaluation of postural BP changes should be a part of nephrology practice.

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“…with claudication) or asymptomatic PAD would also have involvement of another arterial bed. 3–5 Polyvascular disease imposes the highest risk for new or recurrent cardiovascular events around the world. 6–8…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, the polyvascular condition is more frequent in patients who present with PAD, than in those with CAD or CVD presentations. 3–5 PAD can, therefore, be considered a marker of disseminated atherosclerosis. These facts represent the main foundation of the INDAGA studies, a series of three multicenter registries designed to assess PAD in high-risk stable outpatients attending Internal Medicine, Cardiology, and Neurology clinics in Mexico.…”

Section: Introductionmentioning

confidence: 99%

Peripheral artery disease in outpatients with a recent history of acute coronary syndrome or at high atherothrombotic risk

et al. 2020

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Objectives The frequency and implications of peripheral artery disease (PAD) in some risk groups are not entirely characterized in Latin America. We studied PAD prevalence, risk factors, and six-month outcomes in stable outpatients with a history of a recent acute coronary syndrome (ACS), or at high coronary risk. Methods We recruited 830 outpatients in 43 Mexican sites (median age: 64.8 years; 57.8% men). Inclusion criteria were age >18 years, and ACS within 30 days, or age <55 years plus ≥2 major vascular risk factors, or age ≥55 years plus ≥1 vascular risk factors. Patients received standardized assessments at baseline and six-month follow-up for medical history, ankle-brachial index (ABI), and the Edinburgh Claudication Questionnaire (ECQ). Results ABI <0.8 was found in 10.5%, <0.9 in 22.5%, >1.3 in 4.8%, and >1.4 in 3.6%, without differences according to sex or selection criteria. Positive ECQ was found in 7.6%. ABI <0.9 was directly associated with age, diabetes, ACS, and chronic kidney disease, but inversely associated with BMI >27. The six-month case-fatality and atherothrombotic events rates were 1.6% and 3.6%, respectively. In patients with ABI <0.9 and ABI <0.8, the six-month case-fatality rates were 2.5% ( p = 0.27) and 5.4% ( p = 0.03), respectively. In a Cox proportional-hazards model, baseline factors associated with death were age ≥65, ABI <0.8, and ACS. Conclusions Subclinical PAD is more common than symptomatic claudication in high-risk coronary outpatients. Low ABI is associated with reduced short-term survival in patients with recent ACS or at high coronary risk.

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The relationship between elevated serum uric acid and arterial stiffness in a healthy population

Cited by 6 publications

References 32 publications

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout—An Update

Comparative Evaluation of Orthostatic Hypotension in Patients with Diabetic Nephropathy

Peripheral artery disease in outpatients with a recent history of acute coronary syndrome or at high atherothrombotic risk

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