The relationship between endogenous testosterone and lipid profile in middle-aged and elderly Chinese men

Zhang, Nan; Zhang, Haiqing; Zhang, Xu; Zhang, Bingchang; Wang, Furong; Wang, Chenggang; Zhao, Meng; Yu, Chunxiao; Gao, Ling; Zhao, Jiajun; Guan, Qingbo

doi:10.1530/eje-13-0802

Cited by 55 publications

(44 citation statements)

References 49 publications

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“…Conversely, high levels of testosterone are related to favorable cardiovascular risk profile [4]. Furthermore, an inverse relationship between testosterone and atherogenic lipid profile including total cholesterol, LDL-cholesterol and triglycerides has been demonstrated, while the association of HDL cholesterol with testosterone is positive [5]. Expanding further these observations, we recently showed that low plasma testosterone is associated with adverse cardiovascular outcomes in middle-aged hypertensive patients [6].…”

Section: Introductionmentioning

confidence: 79%

Inverse association of total testosterone with central haemodynamics and left ventricular mass in hypertensive men

et al. 2016

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Section: Introductionmentioning

confidence: 79%

Inverse association of total testosterone with central haemodynamics and left ventricular mass in hypertensive men

et al. 2016

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“…Blood samples were obtained from all the subjects from 8:00 to 10:00 after a minimum 10-h overnight fast [9, 38, 39]. Serum TSH, FT3, FT4, FSH, LH, T, ACTH and COR levels were determined by chemiluminescent methods (Roche, Basel, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

et al. 2016

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Lipotoxicity seriously harms human health, but it is unclear whether lipotoxicity is detrimental to the pituitary. We investigated the correlation between serum triglyceride and pituitary axis hormone levels in epidemiological and animal studies. In the epidemiological study, serum thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were greater in male patients with isolated hypertriglyceridemia than in controls, whereas adrenocorticotropin (ACTH) levels were lower in the patients with hypertriglyceridemia. Pituitary hormone levels correlated with triglyceride levels, even after adjustment for potential confounders. In the animal study, male rats were fed a high-fat or control diet for 28 weeks. As the duration of high-fat feeding increased, the serum and pituitary triglyceride concentrations increased. At early times, the high-fat diet elevated serum TSH and triiodothyronine. At later times, much higher serum TSH levels coupled with reduced thyroxine were observed in the high-fat group. Serum levels of pituitary-gonadal and pituitary-adrenal axis hormones were not affected by the diet. The mRNA and protein expression of Tshβ were greater in the high-fat group than in the control group, whereas expression of Fshβ, Lhβ and Acth had no difference between the groups. Overall, serum triglyceride levels were associated with pituitary-thyroid axis hormone levels.

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“…Testosterone deficiency is thought to promote atherosclerosis by modulating lipid metabolism [8]. Several clinical and epidemiological studies have reported that serum testosterone levels are inversely correlated with total cholesterol and LDL cholesterol levels [9-11]. Moreover, animal studies have also demonstrated markedly increased serum cholesterol levels in testosterone-deficient male mice [12,13].…”

Section: Introductionmentioning

confidence: 99%

Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet

et al. 2015

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BackgroundTestosterone deficiency is associated with increased serum cholesterol levels. However, how testosterone deficiency precisely affects cholesterol metabolism remains unclear. Therefore, in the current study, we examined the effect of testosterone deficiency on cholesterol metabolism and liver gene expression in pigs fed a high-fat and high-cholesterol (HFC) diet.MethodsSexually mature male miniature pigs (6–7 months old) were randomly divided into 3 groups as follows: intact male pigs fed an HFC diet (IM + HFC), castrated male pigs fed an HFC diet (CM + HFC), and castrated pigs with testosterone replacement fed an HFC diet (CM + HFC + T). Serum testosterone levels and lipid profiles were measured, and gene expression levels associated with hepatic cholesterol metabolism were determined. Furthermore, total hepatic cholesterol contents and the activities of enzymes mediating hepatic cholesterol metabolism were measured.ResultsSerum testosterone levels were significantly decreased in CM + HFC pigs, and testosterone replacement attenuated castration-induced testosterone deficiency. Castration significantly increased the serum levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides, as well as hepatic lipid contents in pigs fed an HFC diet. Compared with IM + HFC and CM + HFC + T pigs, low-density lipoprotein receptor (LDLR) mRNA expression and protein levels were significantly decreased in the livers of CM + HFC pigs. In contrast, we found that compared with IM + HFC pigs, hepatic proprotein convertase subtilisin/kexin type 9 (PCSK9) mRNA and serum PCSK9 protein levels were significantly increased in CM + HFC pigs. Moreover, testosterone treatment reversed the increase in PCSK9 expression in CM + HFC pigs. However, neither castration nor testosterone replacement affected the expression of the other hepatic genes that were tested.ConclusionsThis study demonstrated that castration-induced testosterone deficiency caused severe hypercholesterolemia in pigs fed an HFC diet; furthermore, these effects could be reversed by testosterone replacement therapy. Altered hepatic PCSK9 and LDLR expression, resulting in reduced LDL-cholesterol clearance, may contribute to the increased serum cholesterol levels induced by testosterone deficiency and an HFC diet. These results deepen our understanding of the underlying molecular mechanisms that mediate the effects of testosterone deficiency on cholesterol metabolism.

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The relationship between endogenous testosterone and lipid profile in middle-aged and elderly Chinese men

Cited by 55 publications

References 49 publications

Inverse association of total testosterone with central haemodynamics and left ventricular mass in hypertensive men

Inverse association of total testosterone with central haemodynamics and left ventricular mass in hypertensive men

Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet

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