The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes

Su, Ying; Liu, Xiamin; Sun, Yanming; Jin, Hongbo; Fu, Ruibin; Wang, Y.-Y.; Wu, Yinghui; Luan, Yuanyuan

doi:10.1111/j.1742-1241.2008.01776.x

Cited by 90 publications

(67 citation statements)

References 34 publications

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“…[9][10] Decreased NO bioavailability due to increased oxidative stress or quenching of NO by advanced glycation end-products may underlie the impairment in FMD. [11][12][13] This alteration to NO physiology may play a key role in the hypertension associated with T2DM and its attendant morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

Gilchrist

Winyard

Aizawa

et al. 2013

Free Radical Biology and Medicine

222

209

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Diets rich in green, leafy vegetables have been shown to lower BP and reduce the risk of cardiovascular disease. Green, leafy vegetables and beetroots are particularly rich in inorganic nitrate. Dietary nitrate supplementation, via sequential reduction to nitrite and NO, has previously been shown to lower BP and improve endothelial function in healthy humans.We sought to determine if supplementing dietary nitrate with beetroot juice, a rich source of nitrate, will lower BP, improve endothelial function and insulin sensitivity in individuals with type 2 diabetes (T2DM). Twenty-seven patients, age 67.2 +/-4.9 years, (18 male) were recruited for a double blind, randomised, placebo-controlled crossover trial. Participants were randomised to begin in either order a 2 week period of supplementation with 250 ml beetroot juice daily (active) or 250 ml nitratedepleted beetroot juice (placebo). At the conclusion of each intervention period 24 hour ambulatory blood pressure monitoring, tests of macro and microvascular endothelial function and a hyperinsulinaemic isoglycaemic clamp were performed. After two weeks administration of beetroot juice mean ambulatory systolic BP was unchanged: 134.6 ± 8.4 mmHg versus 135.1 ± 7.8 mmHg (mean ± SD) placebo vs. active -mean difference of -0.5 mmHg (placebo-active), p=0.737 (95% CI -3.9 to 2.8). There were no changes in macrovascular or microvascular endothelial function or insulin sensitivity. Supplementation of the diet with 7.5 mmoles of nitrate per day for 2 weeks caused an increase in plasma nitrite and nitrate concentration, but did not lower BP, improve endothelial function or insulin sensitivity in individuals with T2DM.3

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Section: Introductionmentioning

confidence: 99%

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

Gilchrist

Winyard

Aizawa

et al. 2013

Free Radical Biology and Medicine

222

209

View full text Add to dashboard Cite

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“…Oxidative stress appears to be involved in aging and various diseases, including DM [35]. The glucolipotoxicity is complicated with endothelial dysfunction and susceptible to oxidative stress, as higher blood glucose level is associated with free radical-mediated lipid peroxidation [36]. Oxygen free radicals in DM can cause peroxidative breakdown of phospholipids that lead to accumulation of malondialdehyde (MDA).…”

Section: Oxidative Stress and Endothelial Dysfunctionmentioning

confidence: 99%

Endothelial Dysfunction in Type 2 Diabetes Mellitus

et al. 2015

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Endothelial dysfunction is an imbalance in the production of vasodilator factors and when this balance is disrupted, it predisposes the vasculature towards prothrombotic and pro-atherogenic effects. This results in vasoconstriction, leukocyte adherence, platelet activation, mitogenesis, pro-oxidation, impaired coagulation and nitric oxide production, vascular inflammation, atherosclerosis and thrombosis. Endothelial dysfunction is focussed as it is a potential contributor to the pathogenesis of vascular disease in diabetes mellitus. Under physiological conditions, there is a balanced release of endothelial-derived relaxing and contracting factors, but this delicate balance is altered in diabetes mellitus and atherosclerosis, thereby contributing to further progression of vascular and endorgan damage. This review focuses on endothelial dysfunction in atherosclerosis, insulin resistance, metabolic syndrome, oxidative stress associated with diabetes mellitus, markers and genetics that are implicated in endothelial dysfunction.

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“…Ожирение является только нача-лом каскада физиологических событий, которые ведут к различным ассоциированным с возрастом заболеваниям, включая сахарный диабет (СД). В настоящее время известно, что гипергликемия, даже на стадии предиабета (нарушении толерантно-сти к глюкозе), увеличивает окислительный стресс и, в конечном счете, приводит к клеточному старению [29]. Клеточное старение и апоптоз происходят не только в эндотелиальных и гладкомышечных клет-ках сосудов, но и в эндотелиальных клетках-предше-ственницах [30].…”

Section: окислительный стресс атеросклероз и длина тело-мерunclassified

Telomere Length and Atherosclerosis

Драпкина¹,

Shepel²

2016

Russ J Cardiol

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The relationship between endothelial dysfunction and oxidative stress in diabetes and prediabetes

Abstract: The results showed that endothelial dysfunction and increased OS were present in subjects with IGT and IFG, indicating endothelial damage in these stages.

Cited by 90 publications

References 34 publications

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes

Endothelial Dysfunction in Type 2 Diabetes Mellitus

Telomere Length and Atherosclerosis

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