The relationship between eosinophilia and slow coronary flow

Abstract

AimThe pathophysiology of slow coronary flow (SCF) involves atherosclerosis, small vessel dysfunction, platelet function disorders, and inflammation. It has been known that eosinophils also play a significant role in inflammation, vasoconstriction, thrombosis, and endothelial dysfunction. We propose to evaluate the relationship between eosinophilia and SCF.MethodsAll patients who underwent coronary angiography between January 2011 and December 2013 were screened retrospectively. Of 6,832 patients, 102 patients with SCF (66 males, mean age 52.2±11.7 years) and 77 control subjects with normal coronary angiography (50 males, mean age 50.7±8.1 years) were detected. Baseline characteristics, hematological test results, and biochemical test results were obtained from the hospital database.ResultsBaseline characteristics of the study groups were comparable between groups. There was no significant difference between groups regarding leukocyte count, paletelet count, and mean platelet volume. However, patients with SCF had a higher eosinophil count than the controls (0.24±0.17×103/μL vs 0.16±0.15×103/μL, P=0.002). In addition, eosinophil count was found to be correlated with thrombolysis in myocardial infarction (TIMI) frame count in the SCF group (r=0.3, P<0.01). There was no significant correlation between eosinophil count and the number of coronary arteries showing slow flow.ConclusionPatients with SCF have higher blood eosinophil count, and this may play an important role in the pathogenesis of SCF. Elevated baseline eosinophil count may indicate the presence of SCF.

New inflammatory indicators: association of high eosinophil-to-lymphocyte ratio and low lymphocyte-to-monocyte ratio with smoking

“…Both high monocyte, eosinophil, and neutrophil counts and a low lymphocyte count reflect systemic inflammation and physiologic stress and contribute to the development of cardiovascular disease. 28–33…”

“…Both high monocyte, eosinophil, and neutrophil counts and a low lymphocyte count reflect systemic inflammation and physiologic stress and contribute to the development of cardiovascular disease. [28][29][30][31][32][33] The relationships between the LMR, ELR, and NLR and adverse events in patients with oncological and cardiac diseases have been revealed in several recent studies. The NLR, ELR, and LMR, which are easily calculated from the CBC count, have been shown to be potential diagnostic and prognostic indicators of some malignant subtypes and cardiac diseases.…”

Complete blood cell count components and coronary slow-flow phenomenon

“…We read the article by Altas et al8 regarding the relationship between the eosinophil count and the CSFP with great interest. They showed that of the complete blood count components (white blood cells, neutrophils, eosinophils, hemoglobin, and platelets), eosinophils were associated with the CSFP.…”

Eosinophil percentage as a new prognostic marker in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

“…Clinical manifestations of these procoagulant and prothrombotic issues are well described in patients with peripheral eosinophilia such as hypereosinophilic syndromes [21,22]. Furthermore, relatively high peripheral EOS content has been found in patient with vasospastic angina, unstable angina pectoris, instent restenosis, coronary slow flow, and syndrome X [23][24][25][26][27]. After 20 years of follow-up, EOS level was significantly associated with increased risk of future cardiovascular events, and EOS cationic protein was defined as a new biomarker of coronary atherosclerosis [28].…”