The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles

Kutlu, Tayfun; Özkaya, Enis; Sanverdi, Ilhan; Devranoğlu, Belgin; İpekçi, Cansu; Konukçu, Birsen; Şahin, Yavuz; Karateke, Ateş

doi:10.4274/tjod.45656

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Saleh et al (23) also shown that the progesterone level in the HCG injection day is not a predictive factor for pregnancy consequences. Kutlu et al (24) in assessment of patients under IUI treatment showed no difference regarding progesterone level at the time of HCG injection, between cases with or without positive pregnancy.…”

Section: Discussionmentioning

confidence: 92%

Survey of Relation between Midcycle Progesterone Level with IUI Cycles Success Rate

Ghasemzadeh

Mostafavi

Nouri

et al. 2020

ABCMed

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Introduction: Assisted reproductive technology is used routinely for treatment of infertile spouses. Previous studies reported conflicting results regarding effect of progesterone rise at the HCG injection day. The aim of current study is to evaluate the effects of mid cycle progesterone levels in IUI cycles. Methods: In this analytical cross-sectional study, the outcome of treatment in 200 IUI cycles were evaluated. Patients’ demographic findings, progesterone level at the day of HCG injection, number of follicles >16 mm, endometrial thickness and clinical pregnancy rate were recorded. For better evaluation, progesterone levels were divided to <0.5, 0.5-1.5 and >1.5 ng/dl. Results: Patients’ mean age was 29.70±4.38 years. The progesterone levels of <0.5, 0.5-1.5 and >1.5 ng/dl was detected in 24.5%, 56% and 19.5% of patients, respectively. The rate of clinical pregnancy was 27.5%. Cases with positive pregnancy had significantly lower progesterone levels (0.88±0.31 vs.1.11±0.80, p=0.04). The highest pregnancy rate was in progesterone levels 0.5-1.5 compared to levels <0.5 and >1.5 ng/dl (42% vs. 12.2% vs. 5.2%, p<0.001). There was no significant correlation between progesterone levels with endometrial thickness (r=-0.130, p=0.06) and number of follicles >16 mm(r=0.02, p=0.77). Conclusion: The results of current study showed that the increase in progesterone levels at the day of HCG injection accompanies with lower pregnancy rate. However, this increase has no correlation with number of mature follicles and endometrial thickness.

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Section: Discussionmentioning

confidence: 92%

Survey of Relation between Midcycle Progesterone Level with IUI Cycles Success Rate

Ghasemzadeh

Mostafavi

Nouri

et al. 2020

ABCMed

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“…Additionally, compared with the standard regimen, the number of oocytes retrieved and E2 level on hCG trigger day in mild stimulation regimen were significantly decreased. Serum E 2 level reflects the quality of oocytes (19), and it has been shown to promote follicle production, upregulate gonadotropin receptors expression, repress the apoptosis of granulosa cell, and the number of dominant follicles is positively correlated with E 2 levels (20). A previous study also showed that the mild stimulation regimen (CC/LE in combination with Gn) reduced E 2 level on hCG trigger day and decreased the number of mature oocytes when compared with the standard regimen, thereby decreasing the chance of receiving live frozen embryos (21).…”

Section: Discussionmentioning

confidence: 99%

PPOS Protocol Effectively Improves the IVF Outcome Without Increasing the Recurrence Rate in Early Endometrioid Endometrial Cancer and Atypical Endometrial Hyperplasia Patients After Fertility Preserving Treatment

Chen

Cheng²,

et al. 2021

Front. Med.

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Objective: To investigate the effectiveness and recurrence risk of different ovulation stimulation protocols in early-stage endometrioid endometrial cancer (EEC) and atypical endometrial hyperplasia (AEH) patients after successful fertility preserving treatment.Design: A retrospective review of clinical files between June 2012 and July 2018.Setting: University hospital.Patients: Ninety seven women (74 AEH and 23 early-stage EEC patients) underwent in vitro fertilization (IVF) and frozen-thawed embryo transfer (FET) after successful fertility preserving treatment. All patients received megestrol acetate which was initiated immediately after AEH or EEC diagnosis by hysteroscopy. Fertility treatment was initiated after confirmation of complete response by two consecutive hysteroscopic evaluations and endometrium biopsy in a 3-month interval. Women with tubal factors underwent IVF treatment directly. Women who failed to conceive spontaneously within 12 months or after other infertility treatments like ovulation induction for 6 consecutive months or 2 consecutive artificial insemination failures were also offered IVF treatment.Main Outcome Measure (s): The clinical and laboratory embryo data, clinical pregnancy outcomes and endometrial disease recurrence rates.Results: Compared with the standard regimen group, the good-quality embryo rate was higher in progestin primed ovarian stimulation (PPOS) regimen group (P = 0.034). Univariate analysis showed significant differences in age (P = 0.033), treatment time of endometrial lesions (P < 0.001), and duration of Gn treatment (P = 0.018) between the recurrent and non-recurrent groups. In the adjusted model of multivariate logistic regression analysis, the age (P = 0.014) at ovulation induction and treatment time of endometrial lesions (P < 0.001) were significantly correlated with the recurrence of endometrial disease.Conclusions: The PPOS protocol is a feasible and safe strategy to stimulate ovulation during IVF after fertility preservation therapy, and the age at ovulation induction and treatment time of endometrial lesions are two stable predictors of recurrence in endometrial diseases.

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“…The comparison revealed significantly increased levels of progesterone after trigger in both groups; however, although there were estradiol level drops in both groups, the drop in the group with negative pregnancy tests was statistically significant. Significant drops in estradiol concentrations after ovulation trigger are associated with IUI cycle treatment failure [44].…”

Section: Recent Advancesmentioning

confidence: 99%

Intrauterine Insemination: Fundamentals Revisited

Allahbadia

2017

J Obstet Gynecol India

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The relationship between estradiol-progesterone alterations after ovulation trigger and treatment success in intrauterine insemination cycles

Cited by 4 publications

References 29 publications

Survey of Relation between Midcycle Progesterone Level with IUI Cycles Success Rate

Survey of Relation between Midcycle Progesterone Level with IUI Cycles Success Rate

PPOS Protocol Effectively Improves the IVF Outcome Without Increasing the Recurrence Rate in Early Endometrioid Endometrial Cancer and Atypical Endometrial Hyperplasia Patients After Fertility Preserving Treatment

Intrauterine Insemination: Fundamentals Revisited

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