The Relationship between Fish Intake and the Prevalence of Asthma: The Tokorozawa Childhood Asthma and Pollinosis Study

Takemura, Yousuke; Sakurai, Yoshinori; Honjo, Satoshi; Tokimatsu, Akira; Gibo, Motonobu; Hara, Tomokuni; Kusakari, Akira; Kugai, Nobuo

doi:10.1006/pmed.2001.0978

Cited by 62 publications

(63 citation statements)

References 21 publications

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“…The rest of the studies which identified a protective effect of fish conducted their analysis for the study population as a whole. Two studies were identified that found a negative effect of fish consumption on atopic/allergic outcomes in infants/ children [44,45]. Both studies had a cross-sectional design, measuring exposure and outcome at the same time point.…”

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 97%

“…Nine studies observed a beneficial effect of fish intake during infancy/ childhood and atopic outcomes in those infants/children [36][37][38][39][40][41][42][43][44]. Two of the studies observed a negative effect of fish intake on childhood atopy [45,46], and three studies observed no associations [47][48][49].…”

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 97%

“…Also, the study conducted by Huang et al [44] included oily fish in the questionnaire. As far as the atopic outcome measures are concerned, in the study of Takemura et al [45] questionnaires about atopy were answered by parents whereas in the study of Huang et al [44] questionnaires were answered by children. Both studies were focused on clinical outcomes and included a component of doctor diagnosis in their questionnaires.…”

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 99%

“…Both studies used a FFQ. The FFQ in the study of Takemura et al [45] was completed by parents. The study of Huang et al [44], apart from the FFQ, used a 24-h recall and compared the effect between quartiles of intake rather than consumption frequencies.…”

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 99%

See 3 more Smart Citations

Atopy Risk in Infants and Children in Relation to Early Exposure to Fish, Oily Fish, or Long-Chain Omega-3 Fatty Acids: A Systematic Review

Kremmyda

Vlachava

Noakes

et al. 2009

Clinic Rev Allerg Immunol

165

129

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There are two main families of polyunsaturated fatty acids (PUFAs), the n-6 and the n-3 families. It has been suggested that there is a causal relationship between n-6 PUFA intake and allergic disease, and there are biologically plausible mechanisms, involving eicosanoid mediators of the n-6 PUFA arachidonic acid, that could explain this. Fish and fish oils are sources of long-chain n-3 PUFAs and these fatty acids act to oppose the actions of n-6 PUFAs. Thus, it is considered that n-3 PUFAs will protect against atopic sensitization and against the clinical manifestations of atopy. Evidence to examine this has been acquired from epidemiologic studies investigating associations between fish intake in pregnancy, lactation, infancy, and childhood, and atopic outcomes in infants and children and from intervention studies with fish oil supplements in pregnancy, lactation, infancy, and childhood, and atopic outcomes in infants and children. All five epidemiological studies investigating the effect of maternal fish intake during pregnancy on atopic or allergic outcomes in infants/children of those pregnancies concluded protective associations. One study investigating the effects of maternal fish intake during lactation did not observe any significant associations. The evidence from epidemiological studies investigating the effects of fish intake during infancy and childhood on atopic outcomes in those infants or children is inconsistent, although the majority of the studies (nine of 14) showed a protective effect of fish intake during infancy or childhood on atopic outcomes in those infants/children. Fish oil supplementation during pregnancy and lactation or during infancy or childhood results in a higher n-3 PUFA status in the infants or children. Fish oil provision to pregnant women is associated with immunologic changes in cord blood and such changes may persist. Studies performed to date indicate that provision of fish oil during pregnancy may reduce sensitization to common food allergens and reduce prevalence and severity of atopic dermatitis in the first year of life, with a possible persistence until adolescence with a reduction in eczema, hay fever, and asthma. Fish oil provision to infants or children may be associated with immunologic changes in the blood but it is not clear if these are of clinical significance and whether they persist. Fish oil supplementation in infancy may decrease the risk of developing some manifestations of allergic disease, but this benefit may not persist as other factors come into play. It is not clear whether fish oil can be used to treat children with asthma as the two studies conducted to date give divergent results. Further studies of increased long-chain n-3 PUFA provision in during pregnancy, lactation, and infancy are needed to more clearly identify the immunologic and clinical effects in infants and children and to identify protective and therapeutic effects and their persistence.

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Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 97%

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 97%

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 99%

Section: Pufas Eicosanoids Inflammatory Processes and Atopymentioning

confidence: 99%

See 2 more Smart Citations

Atopy Risk in Infants and Children in Relation to Early Exposure to Fish, Oily Fish, or Long-Chain Omega-3 Fatty Acids: A Systematic Review

Kremmyda

Vlachava

Noakes

et al. 2009

Clinic Rev Allerg Immunol

165

129

View full text Add to dashboard Cite

show abstract

“…Patal et al (2002) demonstrated an association between consumption of oily fish and symptomatic wheeze in individuals with and without physician diagnosed asthma. Takemura et al (2002) assessed the relationship between dietary fish intake and the prevalence of asthma among a Japanese childhood population and their results indicated that the frequency of fish intake was positively related to the prevalence of asthma. In a prospective 4-y cohort study of introduction of a fish diet during the first year of life and the risk of developing asthma and allergic rhinitis was evaluated (Nafstad et al, 2003).…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

Mickleborough

Rundell

2005

Eur J Clin Nutr

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Nutraceuticals: Formulations and Commercialization

Zaman

Milani

Bhatt

et al. 2019

Kirk-Othmer Encyclopedia of Chemical Technology

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Nutraceuticals are currently growing alternative option for prevention as well as treatment for many acute and chronic illnesses. At some stage where a single pharmaceutical drug acts as a solo performer to treat the illness, the herbal remedy provides group of ingredients together to eradicate the disease. Many of the pharmaceutical drugs are from herbal origin and acts as a potent solo performer against the disease or disorder. While on the other side group of active ingredients present in herbal remedy may stimulate the effect of main active constituent to treat the disease. The resulting effect of course depends on how each of the ingredient are interacting with each other to stimulate the actions of each other. Though there is vast research going on development of nutraceuticals, the challenges associated with nutraceuticals such as variation in active ingredient content, difficulty in purification, lack of appropriate nomenclature, lack of confine regulations, formulation related challenges as well as solubility problems leads researchers as well as formulators in a direction to find out unmet need to overcome these challenges. The concept of solo and concert performance in regards to nutraceuticals and challenges related to nutraceuticals are described here in this article.

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The Relationship between Fish Intake and the Prevalence of Asthma: The Tokorozawa Childhood Asthma and Pollinosis Study

Cited by 62 publications

References 21 publications

Atopy Risk in Infants and Children in Relation to Early Exposure to Fish, Oily Fish, or Long-Chain Omega-3 Fatty Acids: A Systematic Review

Atopy Risk in Infants and Children in Relation to Early Exposure to Fish, Oily Fish, or Long-Chain Omega-3 Fatty Acids: A Systematic Review

Dietary polyunsaturated fatty acids in asthma- and exercise-induced bronchoconstriction

Nutraceuticals: Formulations and Commercialization

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