The relationship between folic acid and colorectal cancer; a literature review

Kherbek, Haidara; Daoud, Rima; Soueycatt, Tania; Soueycatt, Youssef; Ali, Zain; Ehsan, Julia; Alshehabi, Zuheir; Georgeos, Michael

doi:10.1016/j.amsu.2022.104170

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…This profile showed a significant association with upper gastrointestinal cancer [ 22 ]. A review carried out in 2022 investigated folic acid levels and the risk of colorectal cancer in studies published from 1994 to 2022 and demonstrated that folic acid is a modulator of the risk of developing colorectal cancer [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Homocystein, Vitamin B12 and Folic Acid as Screening Biomarkers in Early Diagnosis and Gastric Cancer Monitoring

Alcântara,

Sant’Anna,

Alcântara

et al. 2024

Medical Sciences

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Gastric cancer has been demonstrating a reduction in the number of cases over the past decades, largely attributed to advancements in public health practices and increased accessibility to educational initiatives for the general population. Nevertheless, it persists as the third leading cause of mortality globally among both men and women. These fatalities are typically associated with delayed disease detection. The current study assessed the levels of homocysteine, vitamin B12, and folic acid as a means of establishing a screening biomarker profile that could be integrated into routine testing protocols to facilitate swift diagnosis of the illness. A total of 207 control subjects and 207 individuals with gastric cancer were scrutinized, with biochemical measurements conducted using chemiluminescence for homocysteine, folic acid, and vitamin B12. The two groups were matched based on age, tumor location, subtype, tumor classification, presence of Epstein-Barr Virus infection (EBV), and Helicobacter pylori (H. pylori). Significant statistical variances were identified in the mean levels of the triad of substances among cancer patients when compared to the control group for all corresponding variables. In conclusion, our study indicated that analyzing the triad of homocysteine, vitamin B12, and folic acid holds diagnostic value for gastric cancer and could potentially serve as an effective screening marker for this type of cancer in the future.

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Section: Discussionmentioning

confidence: 99%

Homocystein, Vitamin B12 and Folic Acid as Screening Biomarkers in Early Diagnosis and Gastric Cancer Monitoring

Alcântara,

Sant’Anna,

Alcântara

et al. 2024

Medical Sciences

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“…A literature review indicated that excessive intake of folate can increase the likelihood of precancerous cell growth. 17 A randomized clinical trial (RCT) indicated a correlation between folic acid supplementation and an increased risk in pre-existing lesions and adenoma multiplicity. 77 There has been substantial interest in this topic.…”

Section: Folic Acid and Cancer Protectionmentioning

confidence: 99%

“…A literature review reported that the risk of rectal cancer is higher in people who have Kirsten rat sarcoma (K-Ras)-mutated tumors with high folate consumption. 17 Furthermore, research has indicated that high folate levels in heavy smokers can possibly exacerbate the cancer-causing effects of smoking. 18 In this review, we delve into the contrasting data surrounding folic acid and its impacts on cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Folic acid: friend or foe in cancer therapy

Thabet,

Alessa,

Al-Smadi

et al. 2024

J Int Med Res

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Folic acid plays a crucial role in diverse biological processes, notably cell maturation and proliferation. Here, we performed a literature review using articles listed in electronic databases, such as PubMed, Scopus, MEDLINE, and Google Scholar. In this review article, we describe contradictory data regarding the role of folic acid in cancer development and progression. While some studies have confirmed its beneficial effects in diminishing the risk of various cancers, others have reported a potential carcinogenic effect. The current narrative review elucidates these conflicting data by highlighting the possible molecular mechanisms explaining each point of view. Further multicenter molecular and genetic studies, in addition to human randomized clinical trials, are necessary to provide a more comprehensive understanding of the relationship between folic acid and cancer.

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“… 148 Fibrous fruits and vegetables may also exhibit an extra anti-colorectal cancer effect due to several protective substances they contain such as folic acid, flavonoids, polyphenolic compounds (including epigallocatechin-3-gallate), selenium, calcium, vitamins A, D, E, and C. 149 Folic acid (vitamin B9) has been demonstrated to have a protective effect against colorectal cancer when balanced at physiological levels through diet. 150 In addition, fiber intake changes the composition of gut microbiota by enriching SCFA-producing bacteria including Bifidobacteriaceae, Enterobacteriaceae, Eubacteriaceae, Lach-nospiraceae, and Ruminococcaceae among several others. 87 …”

Section: Dietary Mediators Of Colorectal Cancer Pathogenesis and Deve...mentioning

confidence: 99%

Microbiome Dysbiosis, Dietary Intake and Lifestyle-Associated Factors Involve in Epigenetic Modulations in Colorectal Cancer: A Narrative Review

Kwao-Zigah,

Bediako-Bowan,

Boateng

et al. 2024

Cancer Control

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Background: Colorectal cancer is the second cause of cancer mortality and the third most commonly diagnosed cancer worldwide. Current data available implicate epigenetic modulations in colorectal cancer development. The health of the large bowel is impacted by gut microbiome dysbiosis, which may lead to colon and rectum cancers. The release of microbial metabolites and toxins by these microbiotas has been shown to activate epigenetic processes leading to colorectal cancer development. Increased consumption of a ‘Westernized diet’ and certain lifestyle factors such as excessive consumption of alcohol have been associated with colorectal cancer. Purpose: In this review, we seek to examine current knowledge on the involvement of gut microbiota, dietary factors, and alcohol consumption in colorectal cancer development through epigenetic modulations. Methods: A review of several published articles focusing on the mechanism of how changes in the gut microbiome, diet, and excessive alcohol consumption contribute to colorectal cancer development and the potential of using these factors as biomarkers for colorectal cancer diagnosis. Conclusions: This review presents scientific findings that provide a hopeful future for manipulating gut microbiome, diet, and alcohol consumption in colorectal cancer patients’ management and care.

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The relationship between folic acid and colorectal cancer; a literature review

Cited by 7 publications

References 35 publications

Homocystein, Vitamin B12 and Folic Acid as Screening Biomarkers in Early Diagnosis and Gastric Cancer Monitoring

Homocystein, Vitamin B12 and Folic Acid as Screening Biomarkers in Early Diagnosis and Gastric Cancer Monitoring

Folic acid: friend or foe in cancer therapy

Microbiome Dysbiosis, Dietary Intake and Lifestyle-Associated Factors Involve in Epigenetic Modulations in Colorectal Cancer: A Narrative Review

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