The relationship between genotype, psychiatric symptoms and quality of life in adult patients with sickle cell disease in São Paulo, Brazil: a cross-sectional study

Abstract

A relação entre genótipo, sintomas psiquiátricos e qualidade de vida em pacientes adultos com doença falciforme em São Paulo, Brasil: um estudo transversal ) showed lower scores for the "general health" and "role-physical" HRQoL domains, without interference from psychiatric symptoms. In the "role-physical" domain, the more severe genotype operated as a protective factor for HRQoL (β = 0.255; P = 0.007). CONCLUSION: The more severe genotypes worsened HRQoL in two domains of physical health (general health and role-physical), but they did not have any influence on mental health, thus suggesting that physicians should be more attentive to aspects of HRQoL relating to the functionality of sickle cell disease patients, so as to be aware of the limitations that these patient live with. RESUMOCONTEXTO E OBJETIVO: A qualidade de vida relacionada à saúde (QVRS) pode ser piorada em pacientes com doença falciforme na presença de transtornos psiquiátricos. O objetivo deste estudo é descrever a sintomatologia psiquiátrica presente no paciente brasileiro com doença falciforme e avaliar a relação desses sintomas com o genótipo da doença e a QVRS do sujeito. ) apresentaram menores médias nos domínios de QVRS de "saúde geral" e de "aspectos físicos", sem interferência dos sintomas psiquiátricos. No domínio "aspectos físicos", o genó-tipo mais grave funcionou como fator protetor da QVRS (β = 0,255; P = 0,007). CONCLUSÃO: Os genótipos mais graves pioraram a QVRS em dois domínios do componente físico ("aspectos físicos" e "saúde geral"), mas não influenciaram o componente mental, sugerindo que o médico deve estar atento aos aspectos da QVRS relacionados com a funcionalidade do portador da doença falciforme, conhecendo as limitações com as quais o paciente convive. IMSc. Psychologist,

Depression, quality of life, and medical resource utilization in sickle cell disease

“…In Brazil, a report on 110 SCD patients found that one-third had depression, and this drove the HRQoL scores lower in this subgroup. 50 In a cohort of children and adolescent SCD patients, depression was also associated with worse HRQoL scores in all domains. 51 Depression was found to be associated with neurocognitive deficits in other patient populations.…”

Quality of life in adults with sickle cell disease: an integrative review of the literature

“…Socio-demographic and genotype aspects of study participants Among the 22 articles selected, the majority of the participants were: women in 21 (95.5%) (1)(2)(3)(4)(5)7,(13)(14)(15)(16)(17)(18)(20)(21)(22)(23)(24)(25)(26)(27)(28) , with HbSS / Sβº Tal genotypes in 19 (86.4%) (1)(2)(4)(5)7,(13)(14)(15)(16)(17)(19)(20)(22)(23)(24)(25)(26)(27)(28) ; unmarried children in 13 (59.1%) (1,(3)(4)(5)13,15,(20)(21)(22)(23)(24)…”

“…This review demonstrated that six HRQoL assessment scales were used, three generic and three specific. The generic ones were: Medical Outcome Study 36 item Short Form -SF36 (n = 11) (1,4,(13)(14)(16)(17)21,23,(26)(27)(28) ; World Health Organization Quality of Life Assessment Instrument Bref -WHOQOL-Bref (n = 7) (3,15,(19)(20)22,(24)(25) and EuroQol EQ-5D (n = 1) (18) .…”

“…Patients with FD had QOL (n = 6) (3,12,14,23,26,28) , HRQoL worse than the general population (n = 3) (13,14,27) , work (n = 3) (22)(23)25) and low-paid jobs (n = 1) (23) .…”

“…One study showed that symptoms of depression were present in 30% of participants, anxiety symptoms in 12.7% and alcohol abuse in 9.1% (26) . It was also possible to verify that pain (13,(15)(16)(17)(18)(19)25,28) and psychological distress (18) contributed to reduce the HRQoL scores, and their score was significantly reduced when pain levels increased (13) .…”