The Relationship Between Glycosylated Hemoglobin and Myocardial Perfusion Imaging

Fillipon, Nicole M. Lynn; Kitkungvan, Danai; Dani, Sourbha S.; Downey, Brian C.

doi:10.1002/clc.22028

Cited by 7 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 SBP and DBP were significantly higher (p<0.05) in T2DM compared to controls. Our results are also supported by similar studies in India 26 and in USA, 27 which showed significantly higher (p<0.05) SBP and DBP in T2DM patients compared to normal controls. The hypertension is also suggestive of cardiovascular complications in DM patients.…”

Section: Discussionsupporting

confidence: 90%

The role of glycated hemoglobin (HbA1c) and serum lipid profile measurements to detect cardiovascular diseases in type 2 diabetic patients

Naeem

Khattak

Rehman

et al. 2016

SE Asia J. Pub. Health

View full text Add to dashboard Cite

Patients with diabetes are considered to be at more risk of dyslipidemia and hypertension, hence targets for cardiovascular diseases. This study describes the possible role of Glycated Hemoglobin (HbA1c) and serum lipid profile as a biomarker in the detection of cardiovascular diseases. A cross-sectional study was carried out on 54 (33 males and 21 females) type 2 diabetes (T2DM) patients at Ayub Teaching Hospital (ATH), Abbottabad and Mardan Medical Complex (MMC), Mardan, Khyber Pukhtunkhwa (KP), Pakistan. The control group comprised of 20 (13 males and 7 females) healthy human samples. The patients had significantly higher (p<0.05) Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), HbA1c, Fasting Blood Glucose (FBG), Total Cholesterol (TC), Triglyceride (TG) compared to control subjects. Only High Density Lipoprotein (HDL) was found to be significantly (p<0.05) lower in the patients compared to controls. With regards to gender, in the female patients SBP, DBP, TC and Low Density Lipoprotein (LDL) were significantly higher (p<0.05) compared to males patients. The HbA1c was found to be significantly higher (p<0.05) in males. Results also revealed that patients having HbA1c>7.0%, had higher TG than those with HbA1c≤7.0%. Furthermore, 14.2% patients with HbA1c>7.0% had cerebrovascular diseases and 28% have ischemic heart diseases. The findings of the current study suggests association of HbA1c with lipid profile in T2DM patients and both might be used as a predictor of cardiovascular diseases in such patients.

show abstract

Section: Discussionsupporting

confidence: 90%

The role of glycated hemoglobin (HbA1c) and serum lipid profile measurements to detect cardiovascular diseases in type 2 diabetic patients

Naeem

Khattak

Rehman

et al. 2016

SE Asia J. Pub. Health

View full text Add to dashboard Cite

show abstract

“…The UK Prospective Diabetes Study showed that better glycemic control was associated with a reduction in both CAD prevalence and mortality after a mean of 10 years of follow-up.¹ 7 Although this is a cross-sectional and retrospective study, poorer glycemic control amongst the subjects with diabetes was associated with more extensive ischemia and infarction on MPI scanning. These findings are in accord with those reported by DeLuca et al and Nicole et al 11 , 12 In a retrospective chart review, DeLuca et al demonstrated that the prevalence of silent myocardial ischemia detected by MPI in diabetic patients who had no known CAD was higher in those with HbA 1c ≥7.6% than in those with HbA 1c <7.6% (50% versus 28%, P <0.005). Nicole et al demonstrated that the risk and prevalence of abnormal MPI (ischemia, infarction, or mixed defect) in patients with symptoms of CAD was greater in diabetic patients than in those without diabetes (41% versus 28%, P <0.001).…”

Section: Discussionsupporting

confidence: 89%

“…In addition, the prevalence of silent myocardial ischemia was greater in patients with poorly controlled diabetes (HbA 1c >7.6%) as compared with those with optimal glycemic control (HbA 1c <7.6%).¹¹ Another study found that the risk for abnormal MPI and the prevalence of myocardial ischemia (detected by MPI) was greater in subjects with diabetes than in subjects without diabetes, and more abnormalities were found in those with poor glycemic control. 12 Similarly, Ravipati et al noted that higher HbA 1c levels were associated with more severe angiographically determined CAD.¹³…”

Section: Introductionmentioning

confidence: 96%

“…Several studies have examined the relationship between long-term glucose control, measured by glycated hemoglobin (HbA 1c ) in patients with diabetes, and the extent and severity of CAD. 11 , 12 DeLuca et al noted that the prevalence of silent myocardial ischemia detected by stress or pharmacological MPI in patients who had no previous history of CAD was greater in those with diabetes than in those without diabetes. In addition, the prevalence of silent myocardial ischemia was greater in patients with poorly controlled diabetes (HbA 1c >7.6%) as compared with those with optimal glycemic control (HbA 1c <7.6%).¹¹ Another study found that the risk for abnormal MPI and the prevalence of myocardial ischemia (detected by MPI) was greater in subjects with diabetes than in subjects without diabetes, and more abnormalities were found in those with poor glycemic control.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus

Shmendi

Pirie

Naidoo

et al. 2014

DMSO

View full text Add to dashboard Cite

BackgroundThe relationship between myocardial perfusion imaging (MPI) abnormalities, diabetes mellitus, and glucose control in South African populations is unknown. It was hypothesized that in subjects undergoing MPI for suspected coronary artery disease (CAD), those with diabetes would have more extensive perfusion defects and that diabetes control would influence MPI abnormalities. The aim of this study was to examine the relationship between the severity of CAD diagnosed with MPI in subjects with and without diabetes and to determine the relationship between diabetes control and extent of CAD.MethodsThis study was a retrospective chart review of 340 subjects in whom MPI scans were performed over a 12-month period.ResultsSubjects with diabetes had a higher prevalence of abnormal MPI, with more extensive ischemia, compared with subjects without diabetes (85.6% versus 68%; odds ratio 2.81, P<0.01). Glycated hemoglobin ≥7.0% was associated with a higher risk of abnormal MPI, with more extensive ischemia, compared with subjects having diabetes and glycated hemoglobin <7.0% (odds ratio 2.46, P=0.03) and those without diabetes (odds ratio 4.55, P=0.0001).ConclusionSubjects with diabetes have more extensive myocardial ischemia when compared with subjects without diabetes. Furthermore, poorer diabetes control is associated with more abnormalities on MPI scanning.

show abstract

“… 40 Lynn Fillipon et al discovered that long-term glycemic control in patients with diabetes can weaken CHD and its associated complications. 41 …”

Section: Discussionmentioning

confidence: 99%

Development and External Validation of Nomogram to Identify Risk Factors for CHD in T2DM in the Population of Northwestern China

Meng¹,

Yang²,

Wang³

et al. 2023

DMSO

View full text Add to dashboard Cite

Purpose Cardiovascular disease is the leading cause of mortality in patients with type 2 diabetes mellitus (T2DM). This study aimed to develop and validate a nomogram for predicting the risk factors for coronary heart disease (CHD) in T2DM in the population of northwestern China. Patients and Methods The records of 2357 T2DM patients who were treated in the First Affiliated Hospital of Xinjiang Medical University from July 2021 to July 2022 were reviewed. After some data (n =239) were excluded, 2118 participants were included in the study and randomly divided into a training set (n =1483) and a validation set (n = 635) at a ratio of 3:1. Univariate and stepwise regression analysis was performed to screen risk factors and develop predictive models. The results of logistic regression are presented through a nomogram. The C-index, receiver operating characteristic (ROC) curve, calibration plot, and decision curve analysis (DCA) were employed to verify the distinction, calibration, and clinical practicality of the model. Results The stepwise logistic regression analysis suggested that independent factors in patients with T2DM combined with CHD were age, gender, hypertension (HTN), glycated hemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and Uygur, which were associated with the occurrence of CHD. The nomogram demonstrated good discrimination with a C-index of 0.771 (95% CI, 0.741, 0.800) in the training set and 0.785 (95% CI, 0.743, 0.828) in the validation set. The area under curve (AUC) of the ROC curves were 0.771 (95% CI, 0.741, 0.800) and 0.785 (95% CI, 0.743, 0.828) in the training and validation sets, respectively. The nomogram was well-calibrated. The DCA revealed that the nomogram was clinically valuable. Conclusion A nomogram based on 7 clinical characteristics was developed to predict CHD in patients with T2DM.

show abstract

The Relationship Between Glycosylated Hemoglobin and Myocardial Perfusion Imaging

Cited by 7 publications

References 17 publications

The role of glycated hemoglobin (HbA1c) and serum lipid profile measurements to detect cardiovascular diseases in type 2 diabetic patients

The role of glycated hemoglobin (HbA1c) and serum lipid profile measurements to detect cardiovascular diseases in type 2 diabetic patients

Myocardial perfusion imaging for evaluation of suspected ischemia and its relationship with glycemic control in South African subjects with diabetes mellitus

Development and External Validation of Nomogram to Identify Risk Factors for CHD in T2DM in the Population of Northwestern China

Contact Info

Product

Resources

About