The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study

Abstract

There was no significant association between seropositivity for HBsAg or anti-HCV and PC. Further studies are warranted to clarify the association between HBV infection and PC in regions where HBV is endemic.

Chronic Hepatitis B Virus Infection and Risk of Pancreatic Cancer: A Meta-analysis

“…After review, two studies were excluded with the following reasons: a study of HCV infection (El-Serag et al, 2009); a case report (Yoo et al, 2009). Thus, eight articles met the inclusion criteria (de Gonzalez et al, 2008;Hassan et al, 2008;Gordon et al, 2009;Iloeje et al, 2009;Hong et al, 2010;Zhu et al, 2011;Ben et al, 2012;Wang et al, 2012), six of these studies were conducted only in East Asia (de Gonzalez et al, 2008;Iloeje et al, 2009;Hong et al, 2010;Zhu et al, 2011;Ben et al, 2012;Wang et al, 2012) and two in USA (Hassan et al, 2008;Gordon et al, 2009).…”

“…In most of the studies (de Gonzalez et al, 2008;Hassan et al, 2008;Gordon et al, 2009;Zhu et al, 2011;Ben et al, 2012;Wang et al, 2012), pancreatic cancer was diagnosed according the histology. In other studies (Iloeje et al, 2009;Hong et al, 2010), pancreatic cancer is confirmed by histology or diagnosed by symptoms, signs and more than two types of imaging tools. Enzyme-linked immunosorbent assay was used to test the presence of HBsAg and hepatitis B core antigen antibody (anti-HBc), hepatitis B e antigen (HBeAg) and hepatitis B e antibody (anti-HBe).…”

“…Of these eight studies, five were conducted in a hospital-based case-control study design (Hassan et al, 2008;Hong et al, 2010;Zhu et al, 2011;Ben et al, 2012;Wang et al, 2012), three in cohort design (de Gonzalez et al, 2008;Gordon et al, 2009;Iloeje et al, 2009 al., 2012), two in USA (Hassan et al, 2008;Gordon et al, 2009). The selection of controls varied substantially.…”

“…The selection of controls varied substantially. Controls were acute patients (Hassan et al, 2008;Hong et al, 2010;Zhu et al, 2011;Ben et al, 2012;Wang et al, 2012), patients with active HBV infection (Gordon et al, 2009), or volunteers for checkup (de Gonzalez et al, 2008;Gordon et al, 2009;Iloeje et al, 2009). All groups of controls appeared to be selected on the basis of convenience.…”

“…Also, some cohort and case-control studies (de Gonzalez et al, Lei Li 1,3 , Bo Wu 2 , Li-Bo Yang 3 , Guan-Cheng Yin 3 , Ji-Yong Liu 1 * 2008; Hassan et al, 2008;Iloeje et al, 2009;Gordon et al, 2009;Hong et al, 2010;Zhu et al, 2011;Wang et al, 2012;Ben et al, 2012) have been conducted to estimate the relationship between chronic hepatitis B virus infection and pancreatic cancer. But the results were controversial.…”