The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea

Fırat, Selma; Türkkanı, Mustafa Hamidullah; Çiftçi, Bülent; Çiftçi, Tansu Ulukavak; Erdoğan, Yurdanur

doi:10.1007/s11325-011-0492-2

Cited by 81 publications

(38 citation statements)

References 32 publications

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“…[424344] However, other authors concluded that CRP, TNF-α, and IL6 levels in patients with OSAHS are elevated, independently of obesity, and are related to increased metabolic and cardiovascular diseases, sleepiness, and fatigue. [45464748] In our study, there is no association between IL-17, VD, and BMI. Hence, it can be hypothesized that OSAHS is associated with VD deficiency and serum levels of IL-17 increase independently of obesity.…”

Section: Discussioncontrasting

confidence: 62%

Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome

et al. 2017

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PURPOSE:We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea–hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17).METHODS:Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected. The serum levels of VD and IL-17 were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively.RESULTS:Ninety-two severe OSAHS patients and thirty controls were enrolled in the study. All OSAHS patients had VD deficiency. The mean level of VD was at 7.9 ng/ml among OSAHS group versus 16.8 ng/ml among control group. IL-17A levels were elevated (20.3 pg/ml) in OSAHS group compared to healthy group (10.05 pg/ml). VD levels were negatively correlated with nocturia severity (r = −0.26; P = 0.01) and positively correlated with mean O2 saturation (r = 0.59; P = 0.02) and lowest O2 saturation (r = 0.3; P = 0.03). IL-17 levels were positively correlated with nocturia severity (r = 0.24; P = 0.03) and negatively correlated with mean O2 saturation (r = −0.42; P = 0.03). A significant negative association was observed between IL-7 and VD levels (r = −0.64, P = 0.2 10−4). The magnitude of this correlation was higher for important nocturia, lower MSaO2, or higher BMI.CONCLUSIONS:VD deficiency in patients with severe OSAHS is common with a negative association between IL-17 and VD serum levels. Hypoxia could play an important role in this association. Further studies are needed to clarify this relationship.

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Section: Discussioncontrasting

confidence: 62%

Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome

et al. 2017

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“…In OSAS patients, several inflammatory factors can be found in high concentrations, which can be used as biological markers [32], such as interleukin-6 (IL-6) [33], interleukin-8 (IL-8) [34,35], tumor necrosis factor-α (TNF-α) [35], vascular endothelial growth factor (VEGF) [36], leptine [37,38], and C-reactive protein (CRP) [39,40].…”

Section: Inflammatory Markersmentioning

confidence: 99%

The role inflammatory response genes in obstructive sleep apnea syndrome: a review

et al. 2015

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“…Some studies have identified an independent association between sleep characteristics (namely, disordered breathing, duration, and quality ratings) and inflammation (22-33). Other studies have reported that associations between these sleep characteristics and inflammation are accounted for by confounders like disease and adiposity (34-39)).…”

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confidence: 99%

Actigraphy- and Polysomnography-Measured Sleep Disturbances, Inflammation, and Mortality Among Older Men

et al. 2016

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Objectives To evaluate whether objectively-measured sleep characteristics are associated with mortality risk independent of inflammatory burden and comorbidity. Methods The MrOS Sleep Study (conducted in 2003-2005) included community-dwelling older men (n=2531; average age of 76.3 (5.5 s.d.)). Sleep measures from in-home polysomnography and wrist actigraphy and assessments of serum inflammatory markers levels (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), tumor necrosis factor-α soluble receptor II (sTNF-RII) and interferon–γ (IFN-γ)) were obtained. Vital status was ascertained over an average follow-up of 7.4 (1.9 s.d.) years. Results Three of the seven main sleep measures examined were independently associated with greater inflammatory burden. Mortality risk associated with prolonged (≥10% total sleep time) blood oxygen desaturation and short (<5 hours) sleep duration was attenuated to non-significance after adjusting for inflammatory burden or medical burden/lifestyle factors. Severe blood oxygen desaturation (adjusted hazard ratio (aHR)=1.57, 95% confidence interval (CI): 1.11-2.22), sleep fragmentation (aHR=1.32, 95% CI: 1.12-1.57), and a lower percentage of sleep in rapid eye movement (REM; aHR per s.d.=0.90, 95% CI: 0.93-0.97) were independently associated with mortality. Conclusions Short sleep duration and prolonged blood oxygen desaturation were independently associated with inflammatory burden, which attenuated associations between these sleep characteristics and mortality. Medical and lifestyle factors also substantially attenuated most sleep-mortality associations, suggesting complex relations between sleep, inflammation, and disease. Sleep fragmentation, severe blood oxygen desaturation, and the percentage of sleep time in REM were independently related to mortality risk. Future studies with repeated measures of mediators/confounds will be necessary to achieve a mechanistic understanding of sleep-related mortality risk.

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The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea

Abstract: Patients with OSA have elevated serum levels of hs-CRP, a marker for inflammation and an independent risk predictor for cardiovascular morbidity. The severity of OSA is responsible for the elevation of hs-CRP.

Cited by 81 publications

References 32 publications

Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome

Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome

The role inflammatory response genes in obstructive sleep apnea syndrome: a review

Actigraphy- and Polysomnography-Measured Sleep Disturbances, Inflammation, and Mortality Among Older Men

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