The relationship between HL-A antigens and lymphocyte response in ragweed allergy

Yoo, T. J.; Flink, Ronald J.; Thompson, John S.

doi:10.1016/0091-6749(76)90075-0

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Much of the interest in the genetic basis of the immune response to specific allergens has focused on genes in the human MHC, major histocompatibility complex [9,[17][18]. Early family studies, using complex allergens, had indicated tbat a genetic loeus for sensitivity was likely to reside in the human MHC [9,[19][20]. Studies using simple purified allergens bave supported thehypothesis that an immune response locus may reside in tbis region [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97

Rich

Roitman-Johnson

Greenberg

et al. 1992

Clin Experimental Allergy

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Both genetic and environmental influences have been implicated in the pathogenesis of atopic disease. A recent report suggested that a major gene providing susceptibility to atopy was transmitted in a pattern consistent with autosomal dominant inheritance and evidence was presented that places the disease locus near the D11S97 marker on human chromosome 11q. In this report, we present three large, highly characterized pedigrees in which atopy is transmitted in a pattern consistent with autosomal dominant inheritance. Genotypes at the D11S97 and HLA loci were evaluated using both lod score and sib pair methods of analysis. In these pedigrees, we reject close moderate linkage (up to 10 cM) of atopy with both D11S97 and HLA.

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Section: Discussionmentioning

confidence: 99%

Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97

Rich

Roitman-Johnson

Greenberg

et al. 1992

Clin Experimental Allergy

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“…In 1971, Thorsby et al [12] found an increased frequency of HLA-A1, B8 in children with severe asthma. Ragweed hay fever was correlated to HLA antigens in 7 families, so that in 26 family members with ragweed hay fever, 20 had ragweed hay fever associated haplotype and positive, skin tests [7], The investigation was later confirmed [14]. In a Minnesota family of 57 members suffering from ragweed hay fever, a correlation was found between a positive skin test for the major allergen in ragweed pollen and haplotype HLA-A2, B12 [1], and in another study [8] an association between HLA-B7 and rag weed hay fever with positive skin tests for the minor allergen Ra5.…”

Section: Discussionmentioning

confidence: 70%

HLA Antigens in Atopic Dermatitis

Larsen¹,

Grunnet²,

Vase³

1980

Dermatology

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“…Several studies (Levine et al 1972, Marsh et al 1973, Yoo et al 1976, Bruce et al 1976, Scholtz et al. 1976, Seignalet et al 1976, Marsh and Bias 1977 have shown a certain association between atopy and different HLA antigens or haplotypes, within the same family, but without demonstrating a definite association with one specific antigen or haplotype.…”

mentioning

confidence: 95%

The relationship between HLA antigens and Bermuda grass hayfever

et al. 1978

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Associations between atopic diseases and lymphocyte antigens seem to be possible, but not certain (for a review see McMichael and McDevitt 1977). Several studies (Levine et al. 1972, Marsh et al. 1973, Yoo et al. 1976, Bruce et al. 1976, Scholtz et al. 1976, Seignalet et al. 1976, Marsh and Bias 1977 have shown a certain association between atopy and different HLA antigens or haplotypes, within the same family, but without demonstrating a definite association with one specific antigen or haplotype. Rachelefsky and coworkers (1976) found a strong association between atopic asthma and B lymphocyte group 2, which was not paralleled by an association with the HLA complex. Since hayfever is the classical, representative atopic disease, we present here the HLA typing of 141 patients suffering from Bermuda grass hayfever. These patients comprise two groups: 86 of them were studied during the 1975 season; 65 during the 1976 season; and 10 during both seasons. The diagnosis of hayfever was based on a positive correlation between: (a) family history (several cases of proven atopy in three consecutive generations); (b) clinical picture (seasonal rhinitis, conjunctivitis, and asthma during the Bermuda grass blooming season only); and (c) positive skin tests to whole Bermuda grass extract, obtained from the Hollister-Stier Laboratory. The controls were pooled from data on a recently typed healthy Jewish population (Brautbar et al. 1977, Gazit et al. 1978a, b, c, Zamir et al. 1978) so as to match the stratification of the patients into individuals of Ashkenazi (Russia, Poland, and Roumania) and Sephardic (Marocco and Iraq) origin, in a total of 597 controls for 65 patients.For HLA typing the standard N.I.H. technique was employed (Brand et aL 1970) and the lymphocytes were typed for 9 and 16 antigens at locus A and B, respectively, with 120 alloantisera obtained from the N.I.H. serum bank and from local preparations. The results in both groups (1975 and 1976) show an association with allele B27, at a significance of 1%, and this suggests more than a spurious correlation.The data were subjected to a relative risk analysis. The Haldane (1955) relative risk evaluation uses the formula:

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The relationship between HL-A antigens and lymphocyte response in ragweed allergy

Cited by 9 publications

References 6 publications

Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97

Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97

HLA Antigens in Atopic Dermatitis

The relationship between HLA antigens and Bermuda grass hayfever

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