The Relationship between Hue Discrimination and Contrast Sensitivity Deficits in Patients with Diabetes Mellitus

Trick, Gary L.; Burde, Ronald M.; Cordon, Mae O.; Santiago, Julio V.; Kilo, Charles

doi:10.1016/s0161-6420(88)33125-8

Cited by 137 publications

(116 citation statements)

References 16 publications

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“…A variety of alterations in the VCS spatial-frequency profile have been observed in ocular diseases such as glaucoma, which manifests a low spatial-frequency deficit (70)(71)(72), macular disease (73,74), retinitis pigmentosa (75)(76)(77)(78), type 1 diabetes before observable retinopathy (79)(80)(81), and other distal visual conditions (82,83). With damage more proximal to the visual cortex, VCS deficits have been observed in cases of optic nerve neuropathy (84), optic nerve compression (85), and cerebral lesions (86).…”

Section: Discussionmentioning

confidence: 99%

Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity.

Schreiber¹,

Hudnell²,

Geller³

et al. 2002

Environ Health Perspect

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Tetrachloroethylene (also called perchloroethylene, or perc), a volatile organic compound, has been the predominant solvent used by the dry-cleaning industry for many years. The U.S. Environmental Protection Agency (EPA) classified perc as a hazardous air pollutant because of its potential adverse impact on human health. Several occupational studies have indicated that chronic, airborne perc exposure adversely affects neurobehavioral functions in workers, particularly visual color discrimination and tasks dependent on rapid visual-information processing. A 1995 study by Altmann and colleagues extended these findings, indicating that environmental perc exposure at a mean level of 4,980 microg/m(3) (median=1,360 microg/m(3)) alters neurobehavioral functions in residents living near dry-cleaning facilities. Although the U.S. EPA has not yet set a reference concentration guideline level for environmental exposure to airborne perc, the New York State Department of Health set an air quality guideline of 100 microg/m(3). In the current residential study, we investigated the potential for perc exposure and neurologic effects, using a battery of visual-system function tests, among healthy members of six families living in two apartment buildings in New York City that contained dry-cleaning facilities on the ground floors. In addition, a day care investigation assessed the potential for perc exposure and effects among workers at a day care center located in the same one-story building as a dry-cleaning facility. Results from the residential study showed a mean exposure level of 778 microg/m(3) perc in indoor air for a mean of 5.8 years, and that perc levels in breath, blood, and urine were 1-2 orders of magnitude in excess of background values. Group-mean visual contrast sensitivity (VCS), a measure of the ability to detect visual patterns, was significantly reduced in the 17 exposed study participants relative to unexposed matched-control participants. The groups did not differ in visual acuity, suggesting that the VCS deficit was of neurologic origin. Healthy workers in the day care investigation were chronically exposed to airborne perc at a mean of 2,150 microg/m(3) for a mean of 4.0 years. Again, group-mean VCS, measured 6 weeks after exposure cessation, was significantly reduced in the nine exposed workers relative to matched controls, and the groups did not differ significantly in visual acuity. These results suggested that chronic, environmental exposure to airborne perc adversely affects neurobehavioral function in healthy individuals. Further research is needed to assess the susceptibility of the young and elderly to perc-induced effects, to determine whether persistent solvent-induced VCS deficits are a risk factor for the development of neurologic disease, and to identify the no observable adverse effect level for chronic, environmental, perc exposure in humans.

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Section: Discussionmentioning

confidence: 99%

Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity.

Schreiber¹,

Hudnell²,

Geller³

et al. 2002

Environ Health Perspect

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“…More severe vision problems such as glaucoma, diabetic retinopathy, macular degeneration, optic neuropathies, and amblyopia may cause degradation of the entire contrast sensitivity curve. [28][29][30][31][32][33][34] In our study, contrast sensitivity curves both under photopic and mesopic conditions did not show any pathological patterns. Although it was statistically insignificant, at the highest spatial frequency (18 cpd) the difference in contrast sensitivity scores was higher than that of other frequencies.…”

Section: Discussionmentioning

confidence: 70%

The effects of posterior continuous curvilinear capsulorhexis on contrast sensitivity

Bozkurt

Yazıcı

Pekel

et al. 2009

Eye

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Purpose We aimed at evaluating the effects of posterior continuous curvilinear capsulorhexis (PCCC) on contrast sensitivity. Materials and methods In this prospective, randomized, bilateral clinical study, 40 eyes of 20 patients who underwent bilateral cataract surgery were included. The phacoemulsification machine, viscoelastic substances, surgical tools, and intraocular lenses (IOLs) were the same for both eyes. The only difference was that we conducted the PCCC procedure before IOL implantation to one of the eyes of the patients. The selection of the eye that underwent the PCCC procedure was decided randomly. Results The mean photopic contrast sensitivity values at spatial frequencies of 1.5, 3, 6, 12, and 18 cpd (cycles per degree) were 41.55, 59.90, 61.25, 32.35, and 9.75, respectively, and for the control group these values were 39. 05, 56.60, 57.95, 29.80, and 8.75, respectively. The mean mesopic contrast sensitivity values at special frequencies of 1.5, 3, 6, 12, and 18 cpd were 41.20, 54.75, 55.55, 31.70, and 9.00, respectively, and for the control group these values were 38.35, 51.70, 52.15, 30.05, and 8.00, respectively. The mean contrast sensitivity values of the eyes that underwent the PCCC procedure were slightly better than the fellow eyes at all spatial frequencies, but the difference was statistically insignificant (P40.05). Conclusions In early post-operative period, the PCCC procedure exerts some positive effects on contrast sensitivity although these effects are statistically insignificant.

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“…Contrast trick et al 15 compared the capacity for these two parameters to identifying the early visual dysfunction in patients with diabetes. they found that 37.8 % of subjects without retinopathy had abnormalities in both tests.…”

Section: Contrast Sensitivity Testsmentioning

confidence: 99%

Psychophysical Exams as Early Indicators of Diabetic Retinopathy

Pescosolido¹,

Buomprisco²

2013

European Ophthalmic Review

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Retinopathy is a serious and common complication of diabetes that represents the leading cause of blindness, among people of working age, in developed countries. It is estimated that the number of people with diabetic retinopathy (DR) will increase from 126.6 million in 2011 to 191 million by 2030. The visual function that seems to be affected first in the course of DR is probably the contrast sensitivity; in addition, being mainly a macular function, the perception of colour is also compromised. Moreover, the duration of the disease, the levels of glycated haemoglobin (HbA 1c ) and the presence of cystoid macular oedema are strongly associated with the impairment of fixation stability in patients with diabetes with clinically significant macular oedema, suggesting the possible diagnostic role of microperimetry.The test of contrast sensitivity and the microperimetry and the chromatic sensitivity tests have proved to be useful, safe, reproducible and inexpensive tools to diagnose the disease early. KeywordsDiabetic retinopathy, contrast sensitivity, chromatic sensitivity, microperimetry Epidemiological NotesRetinopathy occurs in about 85 % of diabetic patients and, over time, can lead, in a significant percentage of cases, to the complete loss of vision, representing the most common cause of blindness among

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The Relationship between Hue Discrimination and Contrast Sensitivity Deficits in Patients with Diabetes Mellitus

Cited by 137 publications

References 16 publications

Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity.

Apartment residents' and day care workers' exposures to tetrachloroethylene and deficits in visual contrast sensitivity.

The effects of posterior continuous curvilinear capsulorhexis on contrast sensitivity

Psychophysical Exams as Early Indicators of Diabetic Retinopathy

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