The relationship between <i>ACE/AGT</i> gene polymorphisms and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes

Qiao, Yong-Chao; Wang, Min; Zhang, Xiaoxi; Tian, Fang; Chen, Yin-ling; Zhao, Hai-Lu

doi:10.1177/1470320317752955

Cited by 7 publications

(9 citation statements)

References 46 publications

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“…There have been only two studies on this locus in Asians, so further research is needed to verify our results. 20 Sensitivity analysis further validated that the AGT T174M polymorphism is significantly correlated with DN risk. There is no evidence of possible publication bias in the present meta-analysis.…”

Section: Discussionmentioning

confidence: 86%

Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

Liu

Wang

2019

J Renin Angiotensin Aldosterone Syst

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Objective:Although the angiotensinogen (AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN.Methods:We retrospectively extracted relevant studies from Embase as well as PubMed databases. Additionally, a fixed- or random-effects model was employed for calculation of pooled odds ratio (OR) along with 95% confidence interval (CI).Results:In total, we identified six studies (1179 cases and 927 controls) regarding the AGT gene T174M polymorphism. The pooled ORs for the association between the AGT T174M polymorphism and DN risk were not statistically significant under all genetic models (M vs T: OR = 1.22, 95% CI = 0.84–1.75; MM vs TT: OR = 1.94, 95% CI = 0.93–4.04; MT vs TT: OR = 1.11, 95% CI = 0.76–1.63; the dominant model: OR =1.19, 95% CI = 0.80–1.77; the recessive model: OR = 1.94, 95% CI = 0.93–4.03). Subgroup analyses based on the type of race showed the M allele of the AGT T174M polymorphism increased DN risk in Asians, but not in Caucasians.Conclusions:Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.

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Section: Discussionmentioning

confidence: 86%

Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

Liu

Wang

2019

J Renin Angiotensin Aldosterone Syst

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“…A number of important research papers have extensively searched the link of ACE I/D and AGT M235T with several diseases, mainly hypertension 22,10 and diabetes, [23][24][25] often with highly inconsistent findings throughout various ethnic populations worldwide; associations with overweight and obesity, an important risk factor for cardiovascular diseases, have also been reported. 9,26,27 In this context, ACE I/D and AGT M235T polymorphisms association studies in the Tunisian population are very limited, with reports linking them to obesity.…”

Section: Discussionmentioning

confidence: 99%

Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population

Khamlaoui

Mehri

Hammami

et al. 2020

J Renin Angiotensin Aldosterone Syst

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Objective: This study aims to determine whether genetic variants in ACE I/D and AGT M235T are associated with overweight-obesity and body mass index (BMI) in a Tunisian population. Methods: We designed an age- and sex-matched case-control study. The height and weight were measured and BMI was calculated. A total of 259 overweight-obese patients and 369 healthy controls were genotyped for the ACE I/D and AGT M235T genes using polymerase chain reaction and restriction fragment length polymorphism. Results: ACE I/D and AGT M235T genes were associated with BMI, waist circumference and overweight-obesity (p⩽0.001). In an additive model, the I and the M alleles in ACE and AGT variants, respectively, were associated with a lower BMI: –1.45 and −2.29 units, respectively. ACE I/D genotypes were associated with dyslipidemia; AGT M235T genotypes with dyslipidemia and total cholesterol. Conclusion: These data suggest that variations in ACE I/D and AGT M235T affect the risk of overweight-obesity, BMI and dyslipidemia, and could point to a key molecular pathway of metabolic syndrome and its related comorbidities.

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“…Fulya YUKCU et al The effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor a1166c gene polymorphisms… xx ACE2, AT1R, and AT2R are the components of RAS (7). Single nucleotide polymorphisms of DN associated genes have been found to have a major impact on the outcome of the disease, but no gene has been identifi ed to be conclusively indicating the presence of DN (20).…”

Section: U N C O R R E C T E Dmentioning

confidence: 99%

“…It is known that the renin-angiotensin system (RAS) plays an important role in renal hemodynamic alterations in DN and that genes involved in the RAS predispose to the development of DN (5,6). Renin, angiotensinogen (AGT), angiotensin-converting enzyme (ACE), ACE2, angiotensin II type 1 receptor (AT1R), and angiotensin II type 2 receptor (AT2R) are the components of the renin-angiotensin system (RAS) (7). The AT1R, a G-proteincoupled receptor, mediates the impact of angiotensin II on vasoconstriction and cell transport of molecules (8).…”

Section: Introductionmentioning

confidence: 99%

The effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor a1166c gene polymorphisms on the development of diabetic nephropathy in type 2 diabetes mellitus patients

Yükçü¹,

Sipahi²,

Guldiken³

et al. 2023

BLL

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AIMS: Diabetic nephropathy is one of the major complications of Type 2 diabetes mellitus. In this study, we aimed to investigate the effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms on the development of diabetic nephropathy in patients with type 2 diabetes mellitus. METHODS: This study included 100 type-2 diabetes mellitus patients with diabetic nephropathy patients (patient group) and 99 type-2 diabetes mellitus patients without diabetic nephropathy (control group). Polymerase chain reaction and restriction fragment length polymorphism methods were used to identify polymorphisms in the angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C genes. RESULTS: There was no signifi cant difference in genotype frequencies of M235T gene polymorphism between patient and control groups (χ 2 = 4.01, df = 2, p = 0.13). There was no signifi cant difference in genotype frequencies of T174M gene polymorphism between patient and control groups (X 2 = 0.36, df = 2, p = 0.83). There was no signifi cant difference in genotype frequencies of A1166C gene polymorphism between patient and control groups (χ 2 = 0.51, df = 2, p = 0.77). CONCLUSIONS: The results showed no signifi cant difference in angiotensinogen M235T/T174M and angiotensin type 1 receptor A1166C gene polymorphisms between the patient and control groups. Future studies are needed to validate the results of this study and to explore underlying mechanisms (Tab.

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The relationship between ACE/AGT gene polymorphisms and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes

Cited by 7 publications

References 46 publications

Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

Association of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen (AGT M235T) polymorphisms with the risk of obesity in a Tunisian population

The effects of angiotensinogen M235T/T174M and angiotensin type 1 receptor a1166c gene polymorphisms on the development of diabetic nephropathy in type 2 diabetes mellitus patients

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