The relationship between IL-17A and IL-22 expression and clinical severity in patients with moderate/severe persistent allergic rhinitis

Shahsavan, Shaghayegh; Pirayesh, Ashkan; Samani, Omid Zargari; Shirzad, Hedayatollah; Zamani, Mohamad Ali; Amani, Soroush; Kazemi, Seyyedeh Maryam; Moghni, Mandana; Deris, Fatemeh; Bageri, Nader; Salimzadeh, Loghman; Tavakoli, Ghadir; Arjenaki, Mostafa Gholami

doi:10.1016/j.amjoto.2018.12.009

Cited by 9 publications

(11 citation statements)

References 25 publications

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“…In the present study, histopathological observations indicated a high degree of eosinophil infiltration in the interstitium of the nasal mucosa and an increase in the thickness of the nasal mucosa in the mouse model of AR. Furthermore, the degree of eosinophil infiltration and the thickness of the nasal mucosa were reduced by IL-37, which is consistent with the results of a study performed by Shahsavan et al (29). These results indicated that IL-37 may attenuate the allergic inflammatory response by decreasing eosinophil infiltration in the interstitium of the nasal mucosa.…”

Section: Discussionsupporting

confidence: 91%

IL‑37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis

2020

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Allergic rhinitis (AR) is the allergic inflammation of immune cells in the nasal mucosa, caused by an abnormal T-cell response. Interleukin (IL)-37, a unique member of the IL-1 family with broad anti-inflammatory roles in various autoimmune diseases, participates in the immune regulation of AR. However, the regulatory mechanism of IL-37 in AR has remained elusive. In the present study, a mouse model of AR was established by treating mice with ovalbumin (OVA). Following systemic administration of IL-37, the effects of the cytokine on allergic symptoms were evaluated. The nasal mucosal infiltration of eosinophils was assessed by histopathological observation. The serum and nasal lavage fluid concentrations of immunoglobulin (Ig)E, IgG1, IgG2a, interferon (IFN)-γ, IL-4, IL-13, IL-17a and CC motif cytokine ligand (CCL)11 were determined by ELISA. Treatment with OVA resulted in allergic symptoms, including enhanced eosinophil infiltration in the nasal mucosa, increased thickness of the nasal mucosa and increased levels of IgE, IgG1, IgG2a, IL-4, IL-13, IL-17a and CCL11, but the level of IFN-γ was indicated to decrease. After IL-37 treatment, the frequency of nasal rubbing and sneezing was reduced compared with that in the OVA group. IL-37 administration also decreased the number of eosinophils in the nasal mucosa and the thickness of the nasal mucosa, as well as the serum and nasal lavage fluid levels of IgE, IgG1, IgG2a, IL-4, IL-13, IL-17a and CCL11, but the level of IFN-γ decreased. In addition, the OVA-induced increases in histamine and substance P levels were reversed by IL-37 administration. CCL11 expression levels were correlated with the expression levels of IFN-γ, IL-4, IL-13, IL-17a, histamine and substance P. In conclusion, IL-37 alleviated the OVA-induced allergic symptoms and allergic inflammatory response by reducing the serum cytokine levels via decreasing CCL11 expression levels in mice.

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Section: Discussionsupporting

confidence: 91%

IL‑37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis

2020

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“…Our findings are in agreement with the majority of clinical studies investigating IL-22 level in patients with allergic rhinitis and/ or allergic asthma and revealed Fig. 1 IL-22, IL-10 and IL-13 level in serum and nasal lavage in patients with allergic airway diseases and healthy individuals that concentration of IL-22 in serum or plasma was higher in these patients than in healthy subjects [27][28][29][30][31][32]. Though, studies investigating local IL-22 level provided controversial results.…”

Section: Discussionsupporting

confidence: 91%

“…Though, studies investigating local IL-22 level provided controversial results. For example, Shahsavan et al found that the gene expression level of IL-22 in human nasal mucosa was higher in patients with persistent allergic rhinitis than in healthy individuals [28]. childrens' with severe asthma bronchoalveolar lavage and did not found differences between asthma group and control group [31].…”

Section: Discussionmentioning

confidence: 98%

“…Our study showed that IL-22 level in nasal lavage negatively correlated with eosinophil count in nasal smear in patients with allergic rhinitis and allergic asthma. In contrary, Shahsavan et al revealed positive link between serum IL-22 level and eosinophil count in nasal mucosa [28]. However, IL-22 level in serum may not reflect the local IL-22 level and this could be the reason for controversial data.…”

Section: In Contrary Andersson Et Al Analysed Il-22 Level Inmentioning

confidence: 95%

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Role of IL-22 in persistent allergic airway diseases caused by house dust mite: a pilot study

et al. 2021

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Background Persistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in the pathogenesis of these diseases. Scientists argue if this cytokine acts as proinflammatory or anti-inflammatory agent. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life. Methods Patients with persistent allergic rhinitis caused by HDM and having symptoms for at least 2 years with or without allergic asthma were involved into the study. Measurements of IL-22, IL-13 and IL-10 and in serum and nasal lavage was performed by ELISA. Questionnaires assessing symptoms severity and quality of life were used. Results A tendency was observed that IL-22 in serum and nasal lavage was higher in patients with allergic airway diseases compared to control group (14.86 pg/ml vs. 7.04 pg/ml and 2.67 pg/ml vs. 1.28 pg/ml, respectively). Positive statistically significant correlation was estimated between serum IL-22 and serum IL-10 (rs = 0.57, p < 0.01) and IL-13 (rs = 0.44, p < 0.05) level. Moreover, positive significant correlation was found between IL-22 in nasal lavage and IL-10 in nasal lavage (rs = 0.37, p < 0.05). There was a negative statistically significant correlation between serum IL-22 and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) (rs = − 0.42, p < 0.05). Conclusion Our study showed a possible anti-inflammatory effect of IL-22 in patients with persistent allergic airway diseases caused by HDM.

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“…A study by Shahsavan et al 52 found that patients with moderate to severe persistent AR demonstrated significantly greater IL-22 and IL-17A production than healthy controls, suggesting that the development of persistent AR is influenced by these cytokines. A correlation was found between IL-22 and IL-17A serum levels, along with the mean number of IL-22 and IL-17A positive cells in the nasal mucosa, and specific IgE levels, nasal eosinophil count, and total nasal symptom score.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

Sheha

El‐Korashi

AbdAllah

et al. 2021

JAA

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Background Recent data display the possible role of cytokines such as interleukin-10 (IL-10), IL-17 and IL-23 as a link between dyslipidemia and atopy; however, the relationship between dyslipidemia, allergic rhinitis (AR), and the underlying mechanisms involved is unclear. Purpose To measure the lipid profile and IL-17A level in AR patients in comparison to healthy controls, and correlate serum lipid level with the severity of symptoms and quality of life (QoL) of AR patients. Patients and Methods Peripheral blood samples were collected from AR patients (n=70) and a control group (n=80). Samples were analyzed for serum total IgE by ELISA, serum lipid profile, and IL-17A level by ELISA. Severity of AR symptoms was assessed by visual analogue scale (VAS) score and the rhinoconjunctivitis QoL questionnaire. Results Serum lipid profile and level of IL-17A in AR patients were significantly higher in comparison to controls (P < 0.001). Positive correlations were found between total cholesterol (TC) and the severity of AR and QoL. IL-17A was positively correlated with triglyceride (TG) level and low-density lipoprotein cholesterol (LDL-C) (P=0.011, r =0.303; P=0.043, r =0.242, respectively). Additionally, IL-17A was negatively correlated with high-density lipoprotein cholesterol (HDL-C) level ( P =0.036, r =−0.251). IL-17A was positively correlated with both age and VAS score with statistical significance (P=0.033, r =0.225; P=0.011, r =0.302, respectively). Conclusion Dyslipidemia might play a potential role in the severity of AR symptoms and impairment of patients’ QoL. Highlighting this association might alert physicians to evaluate the lipid profile in AR patients for timely diagnosis and treatment of dyslipidemia in an attempt to improve disease control and improve QoL.

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The relationship between IL-17A and IL-22 expression and clinical severity in patients with moderate/severe persistent allergic rhinitis

Cited by 9 publications

References 25 publications

IL‑37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis

IL‑37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis

Role of IL-22 in persistent allergic airway diseases caused by house dust mite: a pilot study

Lipid Profile and IL-17A in Allergic Rhinitis: Correlation With Disease Severity and Quality of Life

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