The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Yamada, Erika; Himori, Noriko; Kunikata, Hiroshi; Omodaka, Kazuko; Ogawa, Hiroyasu; Ichinose, Masakazu; Nakazawa, Toru

doi:10.1111/aos.13693

Cited by 16 publications

(9 citation statements)

References 37 publications

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“…To be more precise, hypoxia status and parasympathetic pathway-induced retinal ischemia are correlated with glaucoma; this has been proven in previous studies [20,21,22]. In previous studies discussing the effects of obstructive sleep apnea (OSA) on glaucoma, including a population-based study conducted in the same region as the current study, patients with OSA showed a greater chance to develop and aggravate glaucoma [23,24,25,26]. The CRS is also characterized by respiratory disturbance and hypoxia due to the nasal ostial obstructions [27,28], and the hypoxia-related mediators including hypoxia-inducible factor 1 α and high-mobility group box 1 would be elevated in patient with CRS and lead to further inflammation process [29,30].…”

Section: Discussionsupporting

confidence: 60%

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Chau

Sun

et al. 2019

IJERPH

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This study investigates the development of glaucoma in subjects with surgery-indicated chronic rhinosinusitis (CRS) by the use of the National Health Insurance Research Database in Taiwan. Individuals that received the functional endoscopic sinus surgery (FESS) with a diagnostic code of CRS were regarded as surgery-indicated CRS and enrolled in the study group. Four non-CRS patients were age- and gender-matched to each patient in the study group. The exclusion criteria included legal blindness, ocular tumor, history of eyeball removal, and previous glaucoma. The outcome was regarded as the development of glaucoma, and conditional logistic regression was used for the statistical analysis, which involved multiple potential risk factors in the multivariate model. A total of 6506 patients with surgery-indicated CRS that received FESS and another 26,024 non-CRS individuals were enrolled after exclusion. The age and gender distributions were identical between the two groups due to matching. There were 108 and 294 glaucoma events in the study group and control group, respectively, during the follow-up period, and the study group had a significantly higher adjusted hazard ratio (1.291, 95% confidential interval: 1.031–1.615). The cumulative probability analysis also revealed a correlation between the occurrence of glaucoma and the CRS disease interval. In the subgroup analysis, the chance of developing open-angle glaucoma and normal-tension glaucoma was significantly higher in the study group than in the control group. In conclusion, the existence of surgery-indicated CRS is a significant risk factor for the development of glaucoma, which correlated with the disease interval.

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Section: Discussionsupporting

confidence: 60%

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Chau

Sun

et al. 2019

IJERPH

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“…We previously identified a significantly lower antioxidant capacity level and higher hydroxylinoleates, oxidation products of the linoleates, in blood samples from subjects with PG and EX as compared with those in control samples [ 9 , 10 , 11 ]. Interestingly, the lower level of blood antioxidant capacity was associated with higher IOP values in patients with glaucoma and control subjects [ 12 ] and with worse visual field defects in OAG [ 13 , 14 ]. More recently, we reported that supplementation with French maritime pine bark/bilberry fruit extracts, which are natural antioxidants compounds, could further reduce the IOP in Japanese patients with controlled PG [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

et al. 2020

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Advanced glycation end products (AGEs), which are the products of a non-enzymatic reaction between reducing sugars and other macromolecules, are critical in aging, as well as metabolic and degenerative diseases. To assess the involvement of AGEs in glaucoma, skin autofluorescence (sAF) level, which is a measurement of AGEs’ accumulation, was compared among Japanese patients with glaucoma (316 with primary open-angle glaucoma (PG) and 127 exfoliation syndrome and glaucoma (EG)) and controls (133 nonglaucomatous controls) (mean age 71.6 ± 12.8 years, 254 men and 322 women). The sAF values were estimated from the middle fingertip using a 365 nm light-emitting diode for excitation and detection at 440 nm emission light. The estimated AGE values (arbitrary unit) were 0.56 ± 0.15, 0.56 ± 0.11, and 0.61 ± 0.11 in the control, PG, and EG groups, respectively (p < 0.0001, analysis of variance); and were significantly higher in the EG group than the control (p = 0.0007) and PG (p < 0.0001) groups. After adjustment for various demographic parameters by multivariate analyses, male sex (standard β = 0.23), EG (0.19), and diabetes (0.09) were associated with higher AGE levels; PG (−0.18) and smoking (−0.19) were associated with lower AGE levels. Age, visual acuity, intraocular pressure, glaucoma medications, lens status, and systemic hypertension were not associated with AGEs. The high AGE level in EG suggested that specific oxidation and glycation mechanisms underlie the glaucoma pathogenesis associated with pseudoexfoliation syndrome.

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“…(9)(10)(11) Interestingly, the lower level of blood antioxidant capacity was associated with higher IOP values in patients with glaucoma and control subjects (12) and with worse visual field defects in OAG. (13,14) Previously, supplementation with flavonoids containing French maritime pine bark/bilberry fruit extracts improved eye health and microcirculation. (15) This evidence prompted us to evaluate the effect of pine tree French maritime pine bark/bilberry fruit extracts on the IOP in Japanese patients with glaucoma.…”

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confidence: 99%

Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma

Manabe

Kaidzu

Tsutsui

et al. 2021

J. Clin. Biochem. Nutr.

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We tested oral French maritime pine bark (40 mg)/bilberry fruit extract (90 mg) supplements for intraocular pressure-lowering effects in Japanese subjects with primary open-angle glaucoma. Eighteen subjects (29 eyes) were recruited with intraocular pressure of ≥15 mmHg who used one to three bottles of antiglaucoma medications. After a 2-week observation (period 1), subjects ingested a tablet/day of Sante ® Glagenox for 4 weeks (period 2). The mean intraocular pressure (17.2 ± 2.3 mmHg) decreased significantly to 15.7 ± 1.9 mmHg (8.7% reduction) at week 4 ( p = 0.0046). The mean morning intraocular pressure (14.1 ± 3.1 mmHg) self-measured using the iCare HOME tonometer during period 1 decreased significantly to 13.3 ± 2.9 mmHg (5.7% reduction) during period 2 ( p = 0.0291). Blood redox parameters, diacron reactive oxygen metabolites, biologic antioxidant potential, and sulfhydryl tests were unchanged after 4-week supplementation. Intra-subject comparisons, compared to period 1, showed pooled, self-measured, period-2 intraocular pressures was significantly lower in nine subjects (50%), unchanged in six subjects (33%), and elevated in three subjects (17%), suggesting some non-responders. Four-week supplementation with French maritime pine bark/bilberry fruit extracts can further reduce intraocular pressure even in Japanese patients with controlled primary open-angle glaucoma. Further study should confirm the intraocular pressure-lowering effects and mechanisms of this supplement in glaucoma management. The study was registered in UMIN (ID: UMIN000033200).

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The relationship between increased oxidative stress and visual field defect progression in glaucoma patients with sleep apnoea syndrome

Abstract: Glaucoma patients with SAS have higher dROM, as well as steeper MD slope, than patients without SAS, suggesting that SAS may induce systemic oxidative stress and promote glaucomatous visual field defect progression.

Cited by 16 publications

References 37 publications

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

The Development of Glaucoma after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

Effects of French maritime pine bark/bilberry fruit extracts on intraocular pressure for primary open-angle glaucoma

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