The relationship between infarct size and mortality and morbidity during short-term and long-term follow-up after acute myocardial infarction

Herlitz, Johan; Hjalmarson, Åke; Lomsky, Milan

doi:10.1016/0002-8703(88)90471-1

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…Large infarct size increases the risk of symptomatic heart failure and cardiac death. 1 2 3 4 One study demonstrated that patients with an infarction >12% of the left ventricle showed a 7% mortality rate at 2 years, while those with an infarction <12% had 0% mortality. 5 Thus, optimizing the strategy to minimize infarct size is essential to STEMI management.…”

Section: Introductionmentioning

confidence: 99%

Platelet Reactivity Was Not Associated with Infarct Size after Primary Percutaneous Coronary Intervention

et al. 2021

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Potent antiplatelet therapy after primary percutaneous coronary intervention (PCI) has the potential to reduce infarct size. This study analyzed the association between on-treatment platelet reactivity and myocardial infarct size in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI. In this single-center, retrospective study, 253 patients who underwent primary PCI for STEMI were divided into two groups according to platelet reactivity measurements (53 patients in the high platelet reactivity [HPR] group and 200 in the non-HPR group). Technetium Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) was performed before hospital discharge. We measured the infarct size using SPECT imaging and serial cardiac biomarker levels, and compared the infarct sizes of each group. The patients with HPR were older (65.5±13.2 vs. 60.6±12.1 years, p=0.011) than the patients with non-HPR. On the other hand, the non-HPR group had a higher incidence of smoking (26.4% vs. 51.0%, p=0.001) than the HPR group. Infarct size was similar between the two groups (22.6±17.3% vs. 24.8±17.7%, p=0.416). Multivariate analysis revealed that onset to balloon time >240 min (odds ratio [OR]=1.92; 95% confidence interval [CI]=1.08–3.40; p=0.025) and anterior infarction (OR=5.28; 95% CI=3.05–9.14; p<0.001) were independent predictors of large (>22%) infarct size. HPR was not a predictor of infarct size assessed by SPECT. The two groups also showed analogous cumulative creatinine kinase-myocardial band and troponin T levels. In conclusion, compared to non-HPR, HPR showed no significant association with myocardial infarct size measured by SPECT imaging in early phase of MI.

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Section: Introductionmentioning

confidence: 99%

Platelet Reactivity Was Not Associated with Infarct Size after Primary Percutaneous Coronary Intervention

et al. 2021

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“…It is well established, that both short-term and long-term prognosis of patients suffering from MI is dependent on the extent of myocardium involved 26 and subsequently the amount of damage inflicted on cardiac structure and function. Furthermore, based on autopsy reports, the extent of MIs can be assessed by judging size, location and extent of Q-waves as well as R-wave abnormalities.…”

Section: Q-wave Sizementioning

confidence: 99%

Prognostic significance of electrocardiographic Q-waves in a low-risk population

et al. 2012

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“…n 'ont pas d#montr# de diff#rence avec ceux qui avaient un TcPPi-SPECT n#gatif (n = 46) quant ~ la fr#quence (inf#rieure ~ !00 bpm), pression art#rielle systolique (100-120 mmHg) ou la pression veineuse centrale (8)(9)(10)(11)(12)(13)(14)(15)(16) It is well known that haemodynamic stability is essential in the anaesthetic management of coronary artery bypass graft (CABG) surgery. A strong correlation between intraoperative tachycardia ~' 2 and myocardial ischaemia I-3 leading to perioperative myocardial infarction (PMI) has been established.…”

Section: Les Buts De Cette Dtude Prospective Dtaient D'#valuer Les Vamentioning

confidence: 99%

Postoperative haemodynamic and pharmacological responses in patients with positive technetium pyrophosphate single-photon emission computed tomography following CABG

et al. 1992

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The relationship between infarct size and mortality and morbidity during short-term and long-term follow-up after acute myocardial infarction

Cited by 5 publications

References 71 publications

Platelet Reactivity Was Not Associated with Infarct Size after Primary Percutaneous Coronary Intervention

Platelet Reactivity Was Not Associated with Infarct Size after Primary Percutaneous Coronary Intervention

Prognostic significance of electrocardiographic Q-waves in a low-risk population

Postoperative haemodynamic and pharmacological responses in patients with positive technetium pyrophosphate single-photon emission computed tomography following CABG

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