The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels

In this study, we aimed to evaluate the effect of CPAP treatment on hemograms of patients with severe OSA in the lack of comorbidities which might affect the real values of hematological parameters.This retrospective cohort study patients selected from those whose polysomnography reports were compatible with severe OSAS and who underwent PAP titration in our sleep medicine department. 49 patients were enrolled to the study. The baseline hemograms of the participants were collected from one of the patients' visits before they started to use CPAP devices. The control hemograms were evaluated from one of the control visits in the first six months of treatment. We examined the red cell distribution width (RDW), mean platelet volume (MPV), hemotocrit (Hct) and platelet (Plt) count from the hemograms.The mean age was 58.2 years ± 11.3 years, 38.8% were female and 61.2% were male. 69.4% were non-smokers and 30.6% were ex-smokers. The mean body mass index (BMI) was 31.6 ± 5.8 while the mean apnea hypopnea index (AHI) was 50.2 ± 29. The mean duration of CPAP therapy was 4.8 months ± 3.3 months. The mean RDW, MPV, Hct and Plt count values before CPAP treatment were in normal ranges of laboratory tests. All of the values reduced after CPAP therapy but only the decrease in MPV was statistically significant.The reduced values supported that CPAP treatment helped to control hypercoagulability and prevented from cardiovascular disorders in OSAS. Hemogram may be a cheap and easily found laboratory test for monitoring the response to CPAP therapy.

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“…Oxidative stress and inflammation were shown to be linked to RDW [24]. Inflammation is related to ineffective erythropoiesis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Tapan¹,

Görgülü²,

Tertemiz³

et al. 2017

J Sleep Disord Ther

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“…(10)(11)(12) Recent studies have reported that RDW levels are elevated in cardiovascular disorders including heart failure, stable coronary disease, acute coronary syndrome, slow coronary flow and in non-cardiovascular diseases, stroke. (13)(14)(15)(16)(17) However, to the best of our knowledge, to evaluate the relation between RDW and AF in patients with hypertensive has not been reported in the literature previously. In this study, we aimed to investigate the relation between RDW and AF in patients with hypertensive Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient?…”

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confidence: 98%

Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient?

et al. 2014

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“…Inflammation has also been shown to be a contributing factor in the pathogenesis of CSF [28,29,30,31]. The increased plasma TM in the CSF group indirectly reflects an increased inflammatory reaction.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Plasma Thrombomodulin in Patients with Coronary Slow Flow

Wang¹,

Jia²,

Chen³

et al. 2017

Cardiology

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Background: It has been reported that coronary slow flow (CSF) is associated with acute myocardial infarction, ventricular tachycardia, ventricular fibrillation, and even sudden cardiac death. Although studies concerning the etiopathogenesis of CSF are scarce, diffuse atherosclerosis and endothelial dysfunction are thought to play important roles. It has been suggested that a high plasma thrombomodulin (TM) level seems to play an important role in the pathogenesis of atherosclerosis and endothelial dysfunction. Objectives: We hypothesized that a high plasma TM level might be associated with CSF and aimed to research the relationship between plasma TM level and CSF. Methods: Fifty-two CSF patients with angiographically proven CSF and 44 cases with normal coronary flow were included in this study. Coronary flow velocity was determined by the thrombolysis in myocardial infarction (TIMI) frame count method. Plasma TM levels were measured in all the study subjects. Results: Plasma TM levels were significantly higher in the CSF group compared to the control group (3.9 ± 0.5 vs. 3.6 ± 0.3 ng/mL, p = 0.01). There was a positive relationship (r = 0.31, p = 0.002) between plasma TM level and mean TIMI frame count (TFC). Factors associated with mean TFC were plasma TM level (β = 0.206, p = 0.038) and red cell distribution width (β = 0.088, p = 0.009) in multiple linear regression analysis. Conclusions: Patients with CSF have a higher plasma TM level, and this may play an important role in the pathogenesis of CSF. An elevated plasma TM level may be a predictor of CSF. Future studies are needed to confirm these results.

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The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels

Abstract: Our findings show that patients with SCF have significantly increased RDW and serum uric acid levels. This may help throw more light on the pathophysiological basis of SCF.

Cited by 67 publications

References 31 publications

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Effect of Continuous Positive Airway Pressure Treatment on Hemograms of Patients with Severe Obstructive Sleep Apnea in the Lack of Comorbidities

Is there any relationship between RDW levels and atrial fibrillation in hypertensive patient?

Evaluation of Plasma Thrombomodulin in Patients with Coronary Slow Flow

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