The Relationship Between Inflammation and Post-traumatic Stress Disorder

Sun, Yajing; Qu, Yuanyuan; Zhu, Jianwei

doi:10.3389/fpsyt.2021.707543

Cited by 31 publications

(15 citation statements)

References 62 publications

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“…Our data verified that MgH 2 was most likely to suppress anxiety/depression-like symptoms of EAE through modulating the inflammatory response rather than remyelination. Besides, these results, following the previous in-depth research on the neurobiological mechanism of depression, show that neuroinflammation plays an important role in the occurrence and development of depression [ 63 – 66 ].…”

Section: Discussionsupporting

confidence: 78%

Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress

Chen

Shao

et al. 2023

J Neuroinflammation

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Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). Anxiety and depression are the most common psychiatric comorbidities of MS, which seriously affect patients’ quality of life, treatment compliance, and prognosis. However, current treatments for anxiety and depression in MS show low therapeutic efficacy and significant side effects. In the present study, we explored the therapeutic effects of a novel low-toxic anti-inflammatory drug, nanoparticulate magnesium hydride (MgH2), on mood disorders of MS. We observed that anxiety/depression-like behaviors in experimental autoimmune encephalomyelitis (EAE) mice were alleviated by MgH2 treatment. In addition, disease severity and inflammatory demyelination were also diminished. Furthermore, we confirmed the suppressive effect of MgH2 on depression in the acute restraint stress model. Mechanistically, MgH2 may play a therapeutic role by promoting microglial M2 polarization, inhibiting microglial M1 polarization, and reducing oxidative stress and mitochondrial damage. Therefore, nanoparticulate MgH2 may be a promising therapeutic drug for psychiatric comorbidities of MS.

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Section: Discussionsupporting

confidence: 78%

Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress

Chen

Shao

et al. 2023

J Neuroinflammation

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“…Further, both preclinical and clinical studies have indicated an association between anxiety and immune regulation. [ 23 24 25 ] Increased levels of IL-6, a pro-inflammatory cytokine, are seen in anxiety, both in the periphery and brain. [ 26 27 ] In our present study, increased levels of IL-6 were seen after TDS in the PFC and hippocampus, in comparison to controls (no TDS) when compared to the control group, and pretreatment with WS lowered the elevated IL-6 levels seen in the experimental (V + TDS) group, in both brain areas.…”

Section: Discussionmentioning

confidence: 99%

Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats

Rehman,

Faizan,

Ali

et al. 2024

Indian Journal of Pharmacology

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AIMS AND OBJECTIVES: Posttraumatic stress disorder (PTSD) is a complex neuropsychiatric pathophysiology with an unmet need for safe, effective, and sustainable therapeutic modalities. Thus, the present study evaluated the effects of Withania somnifera (WS, Ashwagandha) on an experimental model of PTSD in rats. MATERIALS AND METHODS: Wistar rats (200–250 g) were used and time-dependent sensitization (TDS) was used as the experimental model of PTSD. Standardized WS root extract (100 and 300 mg/kg, p.o. for 15 days) was administered with TDS and their effects were observed on neurobehavioral (anxiety) and brain cytokines, corticosterone, and oxidative stress markers. RESULTS: Exposure to TDS resulted in anxiogenic behavior in the elevated plus maze (EPM) test, i.e., reductions in open arm entries and open arm time, as compared to the control group. Pretreatment with WS extract (100 and 300 mg/kg × 14 days) attenuated the TDS-induced anxiogenic activity in a dose-related manner, and these WS effects were comparable to those seen after the comparator drug fluoxetine (10 mg/kg). Assay of brain homogenates showed that TDS also resulted in elevations in brain interleukin-6 and reduction in corticosterone levels in both the hippocampus and prefrontal cortex (PFC), which were reversed after WS pretreatments. Further, WS pretreatment also reversed the TDS-induced changes in brain oxidative stress markers, namely elevated malondialdehyde and reduced glutathione levels in both the hippocampus and PFC. CONCLUSION: These results suggest that WS could have potential as a therapeutic agent for treating PTSD by attenuating anxiogenesis, neuroimmune axis activation, and oxidative stress.

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“…Certain factors that may disrupt the homeostasis of the gut microbiome are likely to contribute to both immune-mediated inflammatory diseases and leaky gut syndrome [ 41 , 42 , 43 , 44 ]. Even though the mechanisms are not entirely clear, excess, uncontrolled psychological stress was shown to predispose patients to a subsequent development of systemic immune diseases and IBD as well [ 45 , 46 , 47 ]. Moreover, the clinical course of IBD often reflects the psychological state of patients; therefore, it seems plausible that, in certain circumstances, psychological interventions (e.g., cognitive behavioral therapy—CBD) may provide benefits for patients with IBD [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases

Fedor

Zöld

Barta

2023

Life

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Background: Inflammatory bowel diseases (Crohn’s disease and ulcerative colitis) and microscopic colitis (lymphocytic and collagenous colitis) are immune-mediated diseases of the gastrointestinal tract, with distinct pathophysiology. Objective: We sought to compare the prevalence of autoimmune diseases between microscopic colitis (MC) and inflammatory bowel diseases (IBDs) in our patient cohorts in their medical history. Methods: We collected data from 611 patients (508 with IBD, 103 with MC). We recorded cases of other autoimmune diseases. The screened documentation was written in the period between 2008 and 2022. We sought to determine whether colonic involvement had an impact on the prevalence of autoimmune diseases. Results: Ulcerative colitis patients and patients with colonic-predominant Crohn’s disease had a greater propensity for autoimmune conditions across the disease course than patients with ileal-predominant Crohn’s disease. Gluten-related disorders were more common in Crohn’s disease than in ulcerative colitis, and slightly more common than in microscopic colitis. In ulcerative colitis, 10 patients had non-differentiated collagenosis registered, which can later develop into a definite autoimmune disease. Conclusions: Predominantly colonic involvement can be a predisposing factor for developing additional autoimmune disorders in IBD. Ulcerative colitis patients may have laboratory markers of autoimmunity, without fulfilling the diagnostic criteria for definitive autoimmune disorders (non-differentiated collagenosis).

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The Relationship Between Inflammation and Post-traumatic Stress Disorder

Cited by 31 publications

References 62 publications

Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress

Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress

Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats

Contrasting Autoimmune Comorbidities in Microscopic Colitis and Inflammatory Bowel Diseases

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