The relationship between lean body mass and bone mineral content in paediatric health and disease

Crabtree, Nicola; Kibirige, M S; Fordham, J N; Banks, L. M.; Muntoni, F.; Chinn, D. J.; Boivin, C. M.; Shaw, Nick

doi:10.1016/j.bone.2004.06.009

Cited by 197 publications

(99 citation statements)

References 42 publications

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“…In accordance with the mechanostat theory [11][12][13]15,16 and recent reports, the markedly reduced RBS is a risk factor for fracture. 19 -22 For example, in the British children with fragility fractures, RBS Z score was Ϫ1.9Ϯ1.5, as reported by Crabtree et al 20 Furthermore, RBS Z scores of Ϫ2.9Ϯ1.1 and Ϫ2.6Ϯ1.5 were noted in girls and boys with fragility fractures resulting from idiopathic juvenile osteoporosis. 22 These observations have led us to speculate that bone strength of our PH patients was properly adapted to muscle demands; however, especially in girls, the risk for fracture may be still increased because of increased BW.…”

Section: Discussionmentioning

confidence: 75%

“…The intensity of a shadowed area reflects an increasing risk for fracture, as hypothesized previously. 20,22 The bolded line reflects the hypothetical fracture threshold value, as suggested by data obtained in children and adolescents with fragility fractures. 20,22 The P value reflects Mann-Whitney statistics for the comparison with control subjects.…”

Section: Discussionmentioning

confidence: 99%

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Bone Mass and Body Composition in Children and Adolescents With Primary Hypertension

et al. 2008

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Abstract-Because primary hypertension (PH) is associated with calcium metabolism, it is hypothesized that PH may be related to osteoporosis risk. The study aimed to evaluate the relationship between body composition and bone strength in hypertensive adolescents. Total body scans using x-ray absorptiometry (DPX-L, GE Healthcare) were performed in 94 PH children aged 6 to 18 years (21 girls and 73 boys). References of healthy control subjects were used for the calculation of Z scores (age and gender matched), SD scores (height and gender matched), and SDs scores (weight and gender matched). Total body bone mineral density, total body bone mineral content (TBBMC), lean body mass (LBM), and fat mass (FM) were investigated. Relative bone strength index was calculated as the TBBMC:LBM ratio. As evidenced by Z scores, PH case subjects had slightly higher total body bone mineral density, TBBMC, and LBM compared with healthy subjects. Reduced LBM/body weight (BW) Z scores of Ϫ1.9Ϯ1.5 and Ϫ1.2Ϯ1.4, increased FM Z scores of ϩ2.5Ϯ2.5 and ϩ1.7Ϯ2.0, and increased FM/BW Z scores of ϩ1.6Ϯ1.3 and ϩ1.1Ϯ1.4 were noted in girls and boys compared with healthy subjects, respectively (PϽ0.001). On the other hand, PH is strictly related to sedentary behavior and nutritional habits with high-sodium and low-calcium intake, and both PH and decreased bone mass are among the main problems of elderly persons. 2,5 Calcium, vitamin D metabolites, proper nutrition, and physical activity (PA) are crucial determinants of peak bone mass. 6 -13 It was shown recently that low serum vitamin D levels correlate with higher blood pressure. 14 Therefore, PH, through its possible associations with calcium and vitamin D metabolism, as well as behavioral factors including nutritional habits and low PA, may alter skeletal status and body composition. Bone mass accrual is highly influenced by mechanical stimulation from skeletal muscles, and the proper muscle-bone interactions during growth are key determinants of skeletal adaptation toward changing loads. [11][12][13]15,16 Low PA, excessive sodium intake, and calcium loss are among the risk factors common not only for osteoporosis but also for PH. 16,17 Because exposure to similar risk factors for both osteoporosis and PH takes place already in childhood, it seems interesting to evaluate the musculoskeletal system at an early stage of PH.The method of choice for the evaluation of both skeletal status and body composition is dual-energy x-ray absorptiometry (DXA). 6 -10,18 -22 DXA offers accurate and precise measurements of total body bone mineral density (TBBMD), total body bone mineral content (TBBMC), lean body mass (LBM; predominantly muscle mass), fat mass (FM), and its fraction of whole body mass. 18 -22 Recently, DXA-derived TBBMC and LBM were implemented as the parameters

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Bone Mass and Body Composition in Children and Adolescents With Primary Hypertension

et al. 2008

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“…Therefore, all analyses were performed without sex distinction, following the tendency of other studies that evaluated PAM effect in patients with OI (Miller and Hangartner 1999;Crabtree et al 2004). …”

Section: Discussionmentioning

confidence: 99%

Pamidronate Affects the Mandibular Cortex of Children with Osteogenesis Imperfecta

et al. 2015

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“…Both measures are related with overall health risks [42,43] which further emphasizes the success of the program. An improved ratio of lean tissue to fat tissue in the body helps prevent chronic disease, contributes to stronger bones [44] helps protect against insulin resistance [45] and is associated with long-term health [46]. Additionally, research on waist circumference measurements suggests that greater levels of fat storage around the waist is associated with a greater risk of the development of heart disease and type II diabetes [42].…”

Section: Discussionmentioning

confidence: 99%

A Five-Year Evaluation of the Bearfit Worksite Physical Activity Program

Patterson¹,

Patterson²,

Walsh³

et al. 2017

Occup Med Health Aff

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Background: Regular participation in physical activity is associated with many health benefits including reduced risk of chronic diseases, premature mortality, and improved mental health. However, many American adults do not engage in enough activity to achieve health benefits. Employers recognize the value of physical activity participation among employees as a means to reduce healthcare costs and increase employee productivity.

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The relationship between lean body mass and bone mineral content in paediatric health and disease

Cited by 197 publications

References 42 publications

Bone Mass and Body Composition in Children and Adolescents With Primary Hypertension

Bone Mass and Body Composition in Children and Adolescents With Primary Hypertension

Pamidronate Affects the Mandibular Cortex of Children with Osteogenesis Imperfecta

A Five-Year Evaluation of the Bearfit Worksite Physical Activity Program

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