The Relationship between Leukocyte Counts and Venous Thromboembolism: Results from RETROVE Study

Vilalta, N.; Vázquez-Santiago, Miquel; Cuevas, Biel; Macho, Raquel; Remacha, Ángel F.; Carrasco, Marina; Mateo, José; Millon, Juan Antonio; Soria, José Manuel Nieto; Souto, Juan Carlos

doi:10.4172/0974-8369.1000400

Cited by 6 publications

(5 citation statements)

References 28 publications

(38 reference statements)

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“…Furthermore, total white blood count was associated with the risk of VTE in medical patients in multivariable analysis, while in surgical patients the association of total WBC and VTE risk was significant at invariable and multivariable analysis. Other studies have reported a high monocyte count to be associated with past VTE 18 . Platelets play a key role in thrombosis 19,20 .…”

Section: Resultsmentioning

confidence: 87%

Prevalence of venous thromboembolism risk factors in hospitalized patients at the University of Nigeria Teaching Hospital, Enugu Nigeria

Ezigbo¹,

Nwagha²,

Nwuzor³

2022

Afr H. Sci.

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Background: Venous thromboembolism (VTE) is a common and lethal disease. Assessing the risk factors will help to modify exposures. Aim: This study, assessed VTE risk factors in hospitalized patients at the University of Nigeria Teaching Hospital, Enugu. Patients and Methods: This was an observational, case-control study. Three hundred and fifty (350) patients were recruited for the study: This comprised 150 medical patients, 140 surgical patients and a population of 60 healthy control group. Subjects were evaluated once using the Caprini risk assessment model (RAM). Results: Over 50% of all hospitalized patients, were at risk for VTE. Surgical patients were at a higher risk than medical patients. Hemoglobin concentration was associated with the risk of VTE in surgical patients, while d-dimer was associated with VTE risk in medical patients. Conclusion: This study shows a high prevalence of VTE risk factors among hospitalized patients at the University of Nigeria Teaching Hospital. Keywords: Venous Thromboembolism; Risk factors; D-dimer; Patients; Nigeria.

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Section: Resultsmentioning

confidence: 87%

Prevalence of venous thromboembolism risk factors in hospitalized patients at the University of Nigeria Teaching Hospital, Enugu Nigeria

Ezigbo¹,

Nwagha²,

Nwuzor³

2022

Afr H. Sci.

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“…Leukocytes contribute significantly to clot formation and are found in both arterial and venous thrombi. 20,21 Leukocytes bind fibrin via integrin receptor α M β 2 (Mac-1), which supports the inflammatory response. 22 Neutrophils, the most abundant leukocyte in circulation, release matrix metalloproteinases, platelet-activating factor, cathepsin G, and elastase.…”

Section: Leukocytesmentioning

confidence: 99%

Thrombus Structural Composition in Cardiovascular Disease

Alkarithi

Duval

Shi

et al. 2021

ATVB

138

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Thrombosis is a major complication of cardiovascular disease, leading to myocardial infarction, acute ischemic stroke (AIS), or venous thromboembolism. Thrombosis occurs when a thrombus forms inside blood vessels disrupting blood flow. Developments in thrombectomy to remove thrombi from vessels have provided new opportunities to study thrombus composition which may help to understand mechanisms of disease and underpin improvements in treatments. We aimed to review thrombus compositions, roles of components in thrombus formation and stability, and methods to investigate thrombi. Also, we summarize studies on thrombus structure obtained from cardiovascular patients and animal models. Thrombi are composed of fibrin, red blood cells, platelets, leukocytes, and neutrophil extracellular traps. These components have been analyzed by several techniques, including scanning electron microscopy, laser scanning confocal microscopy, histochemistry, and immunohistochemistry; however, each technique has advantages and limitations. Thrombi are heterogenous in composition, but overall, thrombi obtained from myocardial infarction are composed of mainly fibrin and other components, including platelets, red blood cells, leukocytes, and cholesterol crystals. Thrombi from patients with acute ischemic stroke are characterized by red blood cell- and platelet-rich regions. Thrombi from patients with venous thromboembolism contain mainly red blood cells and fibrin with some platelets and leukocytes. Thrombus composition from patients with myocardial infarction is influenced by ischemic time. Animal thrombosis models are crucial to gain further mechanistic information about thrombosis and thrombus structure, with thrombi being similar in composition compared with those from patients. Further studies on thrombus composition and function are key to improve treatment and clinical outcome of thrombosis.

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“…10 With longer follow-up of the Atherosclerosis Risk in Communities (ARIC) study component of LITE and far more events than in our previous analysis, we reexamined the association of hematocrit with VTE incidence. Because a few research studies have associated VTE risk with other aspects of the complete blood count, 8,[11][12][13][14] and diseases manifest as altered levels of these often increase VTE risk, we also tested in a supplemental analysis whether higher leukocyte or platelet counts in ARIC also may be associated with elevated risk of VTE.…”

Section: Introductionmentioning

confidence: 99%

Hematocrit and incidence of venous thromboembolism

Folsom

Wang

Parikh

et al. 2020

Research and Practice in Thrombosis and Haemostasis

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Background Patients with polycythemia vera with high hematocrit have increased risk of venous thromboembolism (VTE). Objective To determine whether high hematocrit in the general population is also associated with elevated VTE risk. Methods The prospective Atherosclerosis Risk in Communities Study performed a complete blood count in 13 891 adults aged 45 to 64 in 1987 to 1989. We identified incident hospitalized VTEs through 2015 and performed proportional hazards regression analyses using race‐sex–specific categorization of hematocrit percentiles (ie, <5th, 5th to <25th, 25th to <75th, 75th to <95th, and 95th‐100th percentiles, with the 25th to <75th percentile serving as the reference). Results Over a median follow‐up of 26 years, 800 participants had an incident venous thrombosis of the leg and/or a pulmonary embolism. There was a nonlinear association of hematocrit with VTE incidence, with risk elevated 72% for participants above the 95th percentile of hematocrit compared with the reference. Specifically, hazard ratios (95% confidence intervals) of incident VTE were 1.27 (0.91‐1.76), 1.06 (0.87‐1.28), 1 (reference), 1.17 (0.98‐1.40) and 1.72 (1.30‐2.27) across the 5 hematocrit percentiles, adjusted for age, race, sex, body mass index, smoking status and pack‐years, and other confounding variables. The association of high hematocrit with VTE was limited to provoked VTE, with little evidence for unprovoked VTE. Hemoglobin above the 95th percentile also was associated with an increased risk of VTE. In contrast, there were no significant associations of platelet, leukocyte, neutrophil, or lymphocyte counts with VTE incidence. Conclusion High hematocrit and hemoglobin in a general middle‐aged population sample were associated with increased long‐term risk of VTE, particularly provoked VTE.

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The Relationship between Leukocyte Counts and Venous Thromboembolism: Results from RETROVE Study

Cited by 6 publications

References 28 publications

Prevalence of venous thromboembolism risk factors in hospitalized patients at the University of Nigeria Teaching Hospital, Enugu Nigeria

Prevalence of venous thromboembolism risk factors in hospitalized patients at the University of Nigeria Teaching Hospital, Enugu Nigeria

Thrombus Structural Composition in Cardiovascular Disease

Hematocrit and incidence of venous thromboembolism

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