The relationship between lipid profile and erectile dysfunction

Nikoobakht, Mohammad Reza; Nasseh, Hamidreza; Pourkasmaee, Maziar

doi:10.1038/sj.ijir.3901350

Cited by 60 publications

(44 citation statements)

References 16 publications

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“…In 1994, the Massachusetts Male Aging Study Group reported that the probability of complete impotence was 0% in the older men with HDL values more than 90 mg/dl, whereas the probability increased to 7.2 and 16.1%, respectively when the HDL values dropped to 60 or 30 mg/dl. 8 Just recently, Nikoobakth et al 15 also reported on results compareable to ours, revealing LDL and total cholesterol as significant risk factors for ED with a relative risk between 1.74 and 1.97. Furthermore, several animal studies were able to demonstrate a significant effect of hyperlipidemia on erectile function.…”

Section: Discussionsupporting

confidence: 54%

Vascular risk factors and erectile dysfunction in a cohort of healthy men

Ponholzer

Temml²,

Rauchenwald

et al. 2006

Int J Impot Res

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To determine the impact of vascular risk factors in the genesis of erectile dysfunction (ED) in a cohort of healthy men. Participants of a health-screening project were carefully selected as men without known vascular disease. Erectile dysfunction was quantified via the IIEF5-questionnaire. All men underwent a detailed health examination including determination of blood pressure, blood lipid profile and fasting serum glucose. In total 1519 men (42.977.9 years) were analysed. Age (Po0.01), elevated levels of total cholesterol (P ¼ 0.04) and low-density lipoproteins (LDL) (P ¼ 0.02) were associated with moderately to severly impaired erectile function (IIEF5: o12). Men with total cholesterol 4240 mg/dl had a 2.7 (1.5-4.9)-fold increased risk for moderate to severe ED, the respective figure for LDL 4160 mg/dl was 2.6 (1.4-4.9). In this well characterized, healthy population, elevated serum lipids are the most important risk factors for the development of ED.

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Section: Discussionsupporting

confidence: 54%

Vascular risk factors and erectile dysfunction in a cohort of healthy men

Ponholzer

Temml²,

Rauchenwald

et al. 2006

Int J Impot Res

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“…Manning et al 31 found a correlation between high LDL and organic ED (68.6 vs 32.4% in the psychogenic impotence group), and a clear positive correlation between high LDL and cavernovenous insufficiency was determined. Nikoobakht et al 32 demonstrated that there was a significant correlation between total cholesterol and LDL with ED. According to this study, every mg dl -1 increase in plasma cholesterol and LDL levels decreased IIEF-5 scores by 0.036 and 0.035, respectively.…”

Section: Discussionmentioning

confidence: 99%

Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction

Aldemir¹,

Okulu²,

Neşeli̇oğlu³

et al. 2011

Int J Impot Res

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We investigated the effects of Antep pistachio on International Index of Erectile Function (IIEF) scores, penile color Doppler ultrasound (PCDU) parameters and serum lipid levels in patients with ED. A total of 17 married male patients with ED for at least 12 months were included in this prospective study. Patients were put on a 100 g pistachio nuts diet for 3 weeks. IIEF and PCDU were evaluated before and after the pistachio diet. In addition, plasma total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride were measured before and after dietary modifications from all subjects. Mean IIEF-15 score was 36±7.5 before the diet and 54.2±4.9 after the diet (P ¼ 0.001). Similarly, an increase in all five domains of IIEF was observed after the diet (Po0.05). Mean peak systolic velocity values before and after the pistachio diet were 35.5 ± 15.2 and 43.3 ± 12.4 cm s -1 , respectively (P ¼ 0.018). After the pistachio diet, TC and LDL levels decreased significantly, whereas HDL level increased (P ¼ 0.008, 0.007 and 0.001, respectively). We demonstrated that a pistachio diet improved IIEF scores and PCDU parameters without any associated side effects in patients with ED. Furthermore, the lipid parameters showed statistically significant improvements after this diet.

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“…31 High total cholesterol and LDL cholesterol in men older than 40 were associated with ED in contrast to younger men and controls suggest that hyperlipidemia explains, in part, ED with age. 32 Hypertension causes endothelial dysfunction, and is associated with ED. 22 Blood pressure adjustment and adequate control of other risk factors improves erectile function, unless medications adversely affect it.…”

Section: Sd and Diseasementioning

confidence: 99%

Sexual dysfunction in the elderly: age or disease?

2005

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Sexuality is an important component of emotional and physical intimacy that men and women experience through their lives. Male erectile dysfunction (ED) and female sexual dysfunction increase with age. About a third of the elderly population has at least one complaint with their sexual function. However, about 60% of the elderly population expresses their interest for maintaining sexual activity. Although aging and functional decline may affect sexual function, when sexual dysfunction is diagnosed, physicians should rule out disease or side effects of medications. Common disorders related to sexual dysfunction include cardiovascular disease, diabetes, lower urinary tract symptoms and depression. Early control of cardiovascular risk factors may improve endothelial function and reduce the occurrence of ED. Treating those disorders or modifying lifestyle-related risk factors (eg obesity) may help prevent sexual dysfunction in the elderly. Sexuality is important for older adults, but interest in discussing aspects of sexual life is variable. Physicians should give their patient's opportunity to voice their concerns with sexual function and offer them alternatives for evaluation and treatment.

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The relationship between lipid profile and erectile dysfunction

Cited by 60 publications

References 16 publications

Vascular risk factors and erectile dysfunction in a cohort of healthy men

Vascular risk factors and erectile dysfunction in a cohort of healthy men

Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction

Sexual dysfunction in the elderly: age or disease?

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