The relationship between lipodystrophy-associated body changes and measures of quality of life and mental health for HIV-positive adults

Burgoyne, Robert W.; Collins, Evan; Wagner, Claudio; Abbey, Susan; Halman, Mark; Nur, Margaret; Walmsley, Sharon

doi:10.1007/s11136-004-2580-2

Cited by 40 publications

(39 citation statements)

References 35 publications

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“…Even though the sample size was small, men scored lower on negative mood and homosexual men scored lower on psychological functioning. On a subsample of this study 8 applying a different questionnaire, Blanch and coauthors 9 found that changes in the breast, face, or legs were significantly associated with greater impairment of psychosocial functioning. In the multivariate analysis only changes in the breast remained significant.…”

Section: Lipodystrophy and Quality Of Life 581mentioning

confidence: 78%

“…6,7 Few studies have addressed quality-of-life issues in HIVinfected patients with LD, and its impact has not been es-tablished definitively. Some studies demonstrating effects have used instruments not widely validated in people with HIV infection, 8,9 while others have failed to find correlations with health-related quality of life. 10,11 The main objective of this study was to identify the impact of LD on the health-related quality of life in HIV-infected people taking HAART.…”

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confidence: 99%

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Severity of Lipodystrophy Is Associated with Decreased Health-Related Quality of Life

Guaraldi

Murri

Orlando

et al. 2008

AIDS Patient Care and STDs

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The impact of lipodystrophy (LD) on quality of life is high, but it has not been demonstrated in literature. The objective of the study was to assess the impact of LD on the health-related quality of life (HRQOL) in HIV-infected people on highly active antiretroviral therapy (HAART). Patients with LD phenotype defined by the Multicenter AIDS Cohort Study (MACS) were included. Three different methods were used to define LD severity: both patient and physician evaluation using the HIV Outpatient Study (HOPS) severity scales and the Lipodystrophy Case Definition (LDCD). The HRQOL was evaluated by MOS-HIV Health Survey. Four hundred one patients on HAART for a mean of 108 Ϯ 52 months were evaluated for LD at the Metabolic Clinic of Modena and Reggio Emilia University were enrolled from January 2003 to July 2006. According to self-perceived or physician-based HOPS, 106 (26.5%) and 122 (30.4%) patients had severe LD. Females had significantly more severe LD. Few HRQOL scores correlated to LD severity using the physician-based score (both HOPSph and LDCD), while all the HRQOL scores correlated with LD severity when a patient-based score was used (HOPSpt). In multiple linear regression analysis, Mental Health HRQOL score, gender, body mass index, age, body image satisfaction were independent predictors of patient-based (HOPSpt) LD, while none of the HRQOL scores, but female gender, age, waist-to-hip ratio, limb fat, and body image satisfaction were correlated with physician-estimated HOPSph LD severity. HRQOL was strongly correlated with LD severity when a patientbased score was used. For an overall assessment of the impact of LD on HIV-infected people, both patientbased and physician-based measures are required. 577

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Section: Lipodystrophy and Quality Of Life 581mentioning

confidence: 78%

mentioning

confidence: 99%

Severity of Lipodystrophy Is Associated with Decreased Health-Related Quality of Life

Guaraldi

Murri

Orlando

et al. 2008

AIDS Patient Care and STDs

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“…Alterations in body image faced by persons taking ART can have repercussions on affective and emotional health. Low self-esteem, poor body image, and depression have been associated with LS (Bourgoyne et al, 2005;Peterson et al, 2008). Despite the benefits of ART, treatment may, ironically, reduce quality of life.…”

Section: Discussionmentioning

confidence: 99%

Facial Lipoatrophy: Appearances Are Not Deceiving

Sanches

Mill²,

Machado³

et al. 2009

Journal of the Association of Nurses in AIDS Care

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Lipodystrophy syndrome (LS) has been reported as visible markers that can identify HIV status. Changes in body shape are detrimental in terms of psychological welfare and may affect well-being and increase the stigma associated with HIV disease. In the current study, the psychosocial impact of LS was evaluated. A total of 84 HIV-infected patients receiving antiretroviral therapy and exhibiting dyslipidemia were interviewed in an urban hospital setting in Brazil in 2006 using a standardized questionnaire. Of the 84 patients exhibiting dyslipidemia, 40 patients also exhibited body changes, and of these, 25 had facial lipoatrophy. From a psychosocial perspective, patients presenting with facial lipoatrophy reported alterations in self-image and self-esteem and believed that other people noticed their body changes. The results are relevant for nurses who need to be well-prepared to recognize lipodystrophy, to implement nursing interventions including lifestyle changes, and to provide psychosocial support to patients with LS.

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“…HIV-infected individuals with HAART-related lipodystrophy are significantly more likely than HIV-infected individuals without HAART-related lipodystrophy to report body image dissatisfaction [28][29][30][31][32]. Lipodystropy is associated with diminished self-esteem and depression, fear of stigmatization, problems with dressing and social isolation [18].…”

Section: Consequencesmentioning

confidence: 99%