The Relationship Between Low-Density Lipoprotein Cholesterol Levels and the Incidence of Cardiovascular Disease in High-Risk Patients Treated With Pravastatin

Daida, Hiroyuki; Teramoto, Tamio; Kitagawa, Yasuhisa; Matsushita, Yasuyuki; Sugihara, Masahiro

doi:10.1536/ihj.13-002

Cited by 12 publications

(11 citation statements)

References 44 publications

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“…The APPROACH-J study was a prospective Japanese study that investigated the 2-year incidence rate of cardiovascular events for high-risk patients in primary prevention who had recently started statin therapy. The risk of CAD incidence plateaued at LDL-C levels ≤ 119 mg/dL, which demonstrates the importance of maintaining an LDL-C level of < 120 mg/dL 624 ) . The importance of the comprehensive management of overlapping complicating risk factors in addition to LDL-C, such as smoking, hypertension, and diabetes, was affirmed in this study.…”

Section: Comprehensive Risk Managementmentioning

confidence: 95%

Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017

Kinoshita

Yokote

Arai

et al. 2018

J Atheroscler Thromb

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569

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Section: Comprehensive Risk Managementmentioning

confidence: 95%

Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017

Kinoshita

Yokote

Arai

et al. 2018

J Atheroscler Thromb

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619

569

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“…Most individuals and families with FH may simply be overlooked among the huge number of patients with any CAD caused by more common risk factors. 9) In particular, we expect the high prevalence of …”

Section: Editorial P1mentioning

confidence: 99%

Estimated Prevalence of Heterozygous Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome

et al. 2017

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SummaryHeterozygous familial hypercholesterolemia (FH) represents a strong risk for development of premature coronary artery disease (CAD). However, the majority of patients with FH are undiagnosed and the prevalence likely represents an underestimate in most countries. In Japan, the possible contribution of FH to the development of CAD may be higher because of the low incidence of CAD among the general population. We estimated the prevalence of heterozygous FH by measuring Achilles tendon thickness (ATT) in patients with acute coronary syndrome (ACS).A total of 359 patients suffering from ACS were enrolled in this multicenter registration study. Heterozygous FH was defined according to the diagnostic criteria proposed by the Japan Atherosclerosis Society. After excluding 63 patients because of missing ATT data or plasma triglyceride levels that were 4.5 mmol/L or more, 296 patients were eligible for inclusion in the study. The number of patients with ATT of 9 mm or more was 53 (17.9%). They were significantly younger and had significantly higher LDL cholesterol levels than patients with an ATT less than 9 mm. The prevalence of heterozygous FH was 5.7% (1/17.5) and more prominent in younger patients who were less than 60 years old (7.8%). In patients with ATT of 9 mm or more, approximately 1 in 3.5 fulfilled the criteria for heterozygous FH.We demonstrated the usefulness of measuring ATT by radiography and the high prevalence of heterozygous FH in patients with ACS in Japan, especially in younger patients who were less than 60 years old. (Int Heart J 2017; 58: 88-94)

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“…Hyperlipidaemia is also an important factor in the development of atherosclerosis. The causal relationship between LDL and atherosclerosis has been extensively studied 169,170,[172][173][174][175] .…”

Section: Atherosclerosismentioning

confidence: 99%

Large animal models of cardiovascular disease

Tsang

Rashdan

Whitelaw

et al. 2016

Cell Biochemistry & Function

116

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The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome, transcriptome and proteome, is pivotal to the biological complexity of both normal and abnormal mammalian processes. Despite our advancing knowledge and understanding of cardiovascular disease (CVD) through the principal use of rodent models, this continues to be an increasing issue in today's world. For instance, as the ageing population increases, so does the incidence of heart valve dysfunction. This may be because of changes in molecular composition and structure of the extracellular matrix, or from the pathological process of vascular calcification in which bone‐formation related factors cause ectopic mineralization. However, significant differences between mice and men exist in terms of cardiovascular anatomy, physiology and pathology. In contrast, large animal models can show considerably greater similarity to humans. Furthermore, precise and efficient genome editing techniques enable the generation of tailored models for translational research. These novel systems provide a huge potential for large animal models to investigate the regulatory factors and molecular pathways that contribute to CVD in vivo. In turn, this will help bridge the gap between basic science and clinical applications by facilitating the refinement of therapies for cardiovascular disease. 2016 The Authors. Published by John Wiley & Sons Ltd.

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The Relationship Between Low-Density Lipoprotein Cholesterol Levels and the Incidence of Cardiovascular Disease in High-Risk Patients Treated With Pravastatin

Cited by 12 publications

References 44 publications

Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017

Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017

Estimated Prevalence of Heterozygous Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome

Large animal models of cardiovascular disease

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