The relationship between mental health and risk of active tuberculosis: a systematic review

Hayward, S E; Deal, Anna; Rustage, Kieran; Nellums, Laura B; Sweetland, Annika C.; Boccia, Delia; Hargreaves, Sally; Friedland, Jon S.

doi:10.1136/bmjopen-2021-048945

Cited by 32 publications

(27 citation statements)

References 49 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the results, schizophrenia increases the risk of active tuberculosis, ranging from HR = 1.52 (95% CI: 1.29-1.79) to RR = 3.04 [39,47]. Considering that these results are from an Asian cohort study, it is likely that the risk of tuberculosis itself is higher in Asia, consistent with the results of this study.…”

Section: Discussionsupporting

confidence: 87%

Characteristics of Comorbid Physical Disease in Patients with Severe Mental Illness in South Korea: A Nationwide Population-Based Study (2014-2019)

Lee

Sohn

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose: The purpose of this study was to identify the associations of chronic physical disease between patients with severe mental illness and the general population of South Korea. Methods: This study was conducted with National Health Insurance Corporation (NHIC) data from 2014 to 2019. A total of 842,459 people were diagnosed with severe mental illness (SMI) in this period, and the same number of controls were established by matching by sex and age. A descriptive analysis was conducted on the sociodemographic characteristics of patients with SMI. Conditional logistic regression analysis was performed to identify the associations between comorbid physical disease in patients with SMI and those of the general population. SAS Enterprise Guide 7.1 (SAS, Inc, Cary, NC) were used to perform all statistical tests. Result: The analysis revealed significant differences in medical insurance, income level, and Charlson Comorbidity Index (CCI) weighted by chronic physical disease, between patients with severe mental illness and the general population. Conditional logistic regression analysis between the two groups also revealed significant differences in all nine chronic physical diseases. Conclusions: The study found that people with severe mental illness had more chronic comorbid physical diseases than the general population. Therefore, people with severe mental illness have a reduced quality of life and a higher risk of excess mortality.

show abstract

Section: Discussionsupporting

confidence: 87%

Characteristics of Comorbid Physical Disease in Patients with Severe Mental Illness in South Korea: A Nationwide Population-Based Study (2014-2019)

Lee

Sohn

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“… 40 In summary, the association between pulmonary TB and mental disorders may be bidirectional. 41 , 42 …”

Section: Discussionmentioning

confidence: 99%

Social Support and Depression Among Pulmonary Tuberculosis Patients in Anhui, China

Fang¹,

Wu²,

Tao³

et al. 2022

JMDH

View full text Add to dashboard Cite

Introduction Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis affecting multiple tissues and organs. It is one of the leading causes of death and is a social disease in China. Increasing studies have revealed that the state of mental health and the social support are associated with the morbidity, mortality and community transmission of pulmonary TB patients. However, the previous global TB control and research strategy focused almost solely on the biomedical aspects. Therefore, in this study, we evaluated the level of depression and explored potential factors, including social support domains and socio-demographic characteristics in pulmonary TB patients to research the mental health state and the association between social support and pulmonary TB, ultimately implementing a multilevel intervene. Methods A cross-sectional study was carried out to describe the status of depression and social support, and explore related factors associated with depression among pulmonary TB patients in Anhui Province, China. Five counties (districts) in Anhui Province, China were selected by simple random sampling method. Patients diagnosed with pulmonary TB eligible to the study criteria were investigated. A structured questionnaire composed of information on socio-demographic characteristics, self-rating depression scale (SDS) and social support rating scale (SSRS) was used to collect the data. Results In this study, a total of 250 questionnaires were issued, and the effective questionnaires 237 were actually returned. Of the 237 patients with pulmonary TB, 71.3% of them were male and the mean age was 46.16 years (SD = 13.09). Depression symptoms were observed in 125 (52.7%) participants. Objective support ( β = −0.192, P =0.002) and subjective support ( β = −0.158, P = 0.015) had significantly negative effects on depression, while the effect of support utilization was not statistically significant. In contrast, being female ( β = 0.119, P = 0.036) and patients with positive sputum smear results ( β = 0.140, P = 0.014) were positively related to depression. Patients with monthly income between 500 and 999 were less likely to suffer from depression ( β = −0.134, P = 0.024) than those who were poorer. Additionally, both education level and marital status were found to be correlated with social support and depression state (all P <0.05). Discussion In summary, the prevalence of depressive symptoms in pulmonary TB patients were high in Anhui Province, China. Low levels of social support can be an important predictor of depression symptoms. Therefore, screening for depress...

show abstract

“…The rate of psychiatric diseases at baseline was also higher in patients with history of TB when compared to control (10% vs 3.5%, p=0.034). Despite the fact that the role of psychiatric diseases as a risk factor for developing TB is still under debate, schizophrenia and depression have shown to be possible risk factors for its development [29]. Both diseases share a strong relationship with social determinants, such as homelessness and poverty [29].…”

Section: Discussionmentioning

confidence: 99%

“…Despite the fact that the role of psychiatric diseases as a risk factor for developing TB is still under debate, schizophrenia and depression have shown to be possible risk factors for its development [29]. Both diseases share a strong relationship with social determinants, such as homelessness and poverty [29]. Unfortunately, our data did not retrieve social and economic variables to try to explore these issues in Covid-19 patients and those with a history of TB, but the association between psychiatric diseases and TB can reinforce that theory.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: A matched Case-Control from the Brazilian Covid-19 Registry

Carvalho,

Pereira,

Chagas

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The Covid-19 pandemic caused a negative impact on other infectious diseases control, prevention, and treatment. Consequently, low and middle-income countries suffer from other endemic diseases, such as tuberculosis. This study was designed to compare Covid-19 manifestations and outcomes between patients with previously treated tuberculosis and controls without this condition. Methods: We performed a matched case-control study drawn from the Brazilian Covid-19 Registry data, including in-hospital patients aged 18 and over with laboratory-confirmed Covid-19 from March 1, 2020 to March 31, 2022. Cases were patients with a past history of tuberculosis. Controls were Covid-19 patients without tuberculosis history. Patients were matched by hospital, sex, presence of HIV and number of comorbidities, with a 1:4 ratio. Results: From 13,636 patients with laboratory-confirmed diagnosis of Covid-19 enrolled in this study, 80 had a history of tuberculosis. Statistical differences in history of chronic pulmonary obstructive disease (15% vs 3.2%), psychiatric disease (10% vs 3.5%,), chronic kidney disease (11.2% vs 2.8%) and solid-organ transplantation; (5% vs 0.9%, p<0.05 for all) were higher in patients with a past history of tuberculosis. Prior use of inhalatory medications (5% vs 0.6%,), oral corticoids (8.8% vs 1.9%), immunosuppressants (8.8% vs 1.9%,) and the use of illicit drugs were more common in the case group (6.2% vs 0.3% p<0.05for all). There were no significant differences in in-hospital mortality, mechanical ventilation, need for dialysis and ICU admission. Conclusions: Patients with a history of tuberculosis infection presented a higher frequency of use of illicit drugs, chronic pulmonary obstructive disease, psychiatric disease, chronic kidney disease, solid-organ transplantation, prior use of inhalatory medications, oral corticoids, and immunosuppressants. The outcomes were similar between cases and controls.

show abstract

The relationship between mental health and risk of active tuberculosis: a systematic review

Cited by 32 publications

References 49 publications

Characteristics of Comorbid Physical Disease in Patients with Severe Mental Illness in South Korea: A Nationwide Population-Based Study (2014-2019)

Characteristics of Comorbid Physical Disease in Patients with Severe Mental Illness in South Korea: A Nationwide Population-Based Study (2014-2019)

Social Support and Depression Among Pulmonary Tuberculosis Patients in Anhui, China

Characteristics and outcomes of in-hospital patients with Covid-19 and history of tuberculosis: A matched Case-Control from the Brazilian Covid-19 Registry

Contact Info

Product

Resources

About