The Relationship Between Metabolic Presbycusis and Serum Paraoxonase/Arylesterase Activity

Abstract

To determine the presence of a relationship between metabolic presbycusis and serum paraoxonase/ arylesterase activity. A total of 30 patients who had been admitted to the Ear, Nose, and Throat (ENT) Clinic of Fırat University Medical Faculty and diagnosed as metabolic presbycusis were included in the study. The control group was composed of 30 healthy volunteers. Pure tone audiometry and impedencemeter were performed on all subjects included in the study at the audiometry laboratory of the ENT clinic. The presence of a regular hearing curve, a symmetrical sensorineural hearing loss more than 25 dB with preserved speech discrimination were accepted as criteria for metabolic presbycusis. Blood samples were drawn from the patients prior to the hearing tests. The sera were separated for measurements of total cholesterol, triglyceride, high-density lipoprotein, very low-density lipoprotein, low-density lipoprotein, human serum paraoxonase and arylesterase levels, respectively. No statistically significant difference was found between the patient and the control groups in terms of age and gender. Paraoxonase, arylesterase and paraoxonase/arylesterase, high-density lipoprotein levels were found to decrease in the study group and the difference was found to be statistically significant compared to the control group (P \ 0.001). Low-density lipoprotein and total cholesterol levels were found to increase in the patient group and the difference was found to be significant compared to the control group (P \ 0.001). This study puts forth that especially the type of nutrition and life style are very important with regard to metabolic presbycusis. Furthermore, the results of this study make us think that there could be a relationship between metabolic presbycusis and cardiovascular diseases. In this case, metabolic presbycusis may be a determining parameter in the early diagnosis of cardiovascular diseases. We consider that this study may be the pioneer for further studies conducted with larger patient numbers.

Presbycusis and hyperlipidemia: Is there any link?

“…Presbycusis has a major impact on the quality of human life, and is related to a reduce communication skills, social isolation and possibly exacerbating anxiety-depressive status [7]. The degenerative processes of presbycusis are probably influenced by many factors such as heredity, environmental and systemic comorbidities such as hyperlipidemia, many studies tried to evaluate this relationship, but it is still subject to question [8].…”

Presbycusis and hyperlipidemia: Is there any link?

“…Keles et al [7] compared serum level of metabolic presbycusis patients and control group and reported that total cholesterol was found to be statistically significantly high in those with presbycusis. Our findings disagree with Jones and Davis [24] who found that the study of 85 patients with sensorineural hearing loss showed no significant difference between their cholesterol level and that of the control group.…”

Kualitas Hidup Penderita Presbikusis di RSUD Sultan Syarif Mohamad Alkadrie Pontianak tahun 2019

“…Atrofi ini menyebabkan gangguan pendengaran. 14 Pada penelitian ini didapatkan penderita presbikusis yang disertai riwayat kronik seperti hipertensi dan DM tipe II. Hipertensi dan DM tipe II dapat memacu proses gangguan pendengaran pada lansia.…”