The relationship between motor function, cognition, independence and quality of life in myelomeningocele patients

Luz, Carolina Lundberg; Moura, Maria Clara Drummond Soares de; Becker, Karine Kyomi; Teixeira, Rosaní Aparecida Antunes; Voos, Mariana Callil; Hasue, Renata Hydeé

doi:10.1590/0004-282x20170088

Cited by 11 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some potentially important factors were omitted, largely for practical purposes. Cognition may be one such omitted but important variable 45 . It is likely that cognition plays a meaningful role in function and including this variable could change the effect sizes of the factors we have examined.…”

Section: Discussionmentioning

confidence: 99%

Causal factors affecting gross motor function in children diagnosed with cerebral palsy

MacWilliams

Prasad

Shuckra

et al. 2020

Preprint

View full text Add to dashboard Cite

Cerebral palsy (CP) is a complex neuromuscular condition which may negatively impact gross motor function. Children diagnosed with CP often exhibit spasticity, weakness, reduced motor control, contracture, and bony malalignment. Despite many previous association studies, the causal impact of these impairments on motor function is unknown. In this study, we propose a causal model for motor function as measured by the 66-item Gross Motor Function Measure (GMFM-66), and estimate the direct and total effect sizes of these common impairments using linear regression based on covariate adjustment sets implied by the causal model. We evaluated 300/314 consecutive subjects with cerebral palsy who underwent routine clinical gait analysis. The largest effect sizes, as measured by standardized regression coefficients (standard error), were for static motor control (direct = 0.35 (0.04), total = = 0.40 (0.04)) and dynamic motor control (direct = 0.26 (0.04), total = 0.31 (0.04)), followed by strength (direct = 0.23 (0.04), total = 0.26 (0.04)). The next largest effect was found for gait deviations (direct = total = 0.15 (0.04)). In contrast, common treatment targets, such as spasticity (direct = 0.05 (0.03), total = 0.08 (0.03)) and orthopedic deformity (direct = 0.00 (0.03) to 0.08 (0.03), total = -0.01 (0.03) to 0.11 (0.03)), had relatively small effects. We also show that effect sizes estimated from bivariate models, which fail to appropriately adjust for other causal factors dramatically overestimate the total effect of spasticity (510%), strength (271%), and orthopedic deformity (192% to -2017%). Understanding the relative influences of impairments on gross motor function will allow clinicians to direct treatments at those impairments with the greatest influence on gross motor function and provide realistic expectations of the anticipated functional changes.

show abstract

Section: Discussionmentioning

confidence: 99%

Causal factors affecting gross motor function in children diagnosed with cerebral palsy

MacWilliams

Prasad

Shuckra

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Accordingly, the presence of postural instability, high body mass index and worse baseline motor scores are key predictors of poorer functional and QOL outcomes after DBS (13). On the other hand, QOL is also related to functional independence (14). Floden et al (15) examined the disease, treatment, cognitive, and psychological factors associated with QOL before and after surgery by assessing the strength of these factors in the prediction of QOL outcomes.…”

Section: Discussionmentioning

confidence: 99%

Effect of Deep Brain Stimulation on Quality of Life in Patients with Parkinson’s Disease

Hüzmeli¹,

Yılmaz²

2018

tnd

View full text Add to dashboard Cite

show abstract

“…Pois, quanto maior o nível ou o local onde está localizada a lesão, maior o comprometimento funcional e diminuição da força muscular dos membros inferiores. 11,13…”

Section: Categoria 2 Intervenções Cirúrgicasunclassified

Desenvolvimento biopsicossocial de adultos com Mielomeningocele

Borges

Kovalhuk

2021

Saúde e meio ambient.: rev. interdisciplin.

View full text Add to dashboard Cite

A Mielomeningocele é uma doença decorrente da malformação do tubo neural nas primeiras semanas de gestação. Não possui cura, porém são proporcionados tratamentos ao longo do desenvolvimento para evitar complicações irreversíveis. Objetivo: Mostrar a atual qualidade de vida dos portadores de mielomeningocele e os obstáculos ao longo do seu desenvolvimento. Método: Trata-se de uma pesquisa descritiva exploratória de natureza qualitativa, com cinco indivíduos com sequelas da Mielomeningocele maiores de 18 anos, que foram entrevistados. Resultado: A análise dos dados coletados foi realizada com o apoio da literatura pré-existente, os resultados permitiram compreender o impacto diário desta malformação no desenvolvimento e as dificuldades enfrentadas ao longo dos anos. Conclusão: A partir dos relatos coletados foi possível compreender as limitações desenvolvidas diante das sequelas secundárias, assim como a superação e adaptação dos indivíduos com mielomeningocele ao longo do seu desenvolvimento. Palavras-chave: Mielomeningocele. Qualidade de vida. Perfil de impacto.

show abstract

The relationship between motor function, cognition, independence and quality of life in myelomeningocele patients

Cited by 11 publications

References 22 publications

Causal factors affecting gross motor function in children diagnosed with cerebral palsy

Causal factors affecting gross motor function in children diagnosed with cerebral palsy

Effect of Deep Brain Stimulation on Quality of Life in Patients with Parkinson’s Disease

Desenvolvimento biopsicossocial de adultos com Mielomeningocele

Contact Info

Product

Resources

About