The relationship between mucosal damage in celiac disease and the risk of neurological and psychiatric conditions is much more complex than previously thought

Parisi, Pasquale

doi:10.1111/ene.13614

Cited by 7 publications

(11 citation statements)

References 11 publications

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“…A complex interaction between CD and such psychiatric disorders is proposed in the literature [10,12,15,16]. Theories are often split into specific and non-specific mechanisms [16].…”

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

“…Theories are often split into specific and non-specific mechanisms [16]. Specific mechanisms refer to biological processes that may be producing overlapping pathologies, such as speculation over a direct 'gut-brain' relationship [12,16,17]. Non-specific mechanisms include the social and emotional consequences of CD diagnosis [7].…”

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

“…The proposal of a direct gut-brain relationship contributing to the pathophysiology, commonly features in literature, in particular in reference to schizophrenia and ASD [1,12,16,[18][19][20][21]. Theories often describe autoimmunity and inflammation as potentially playing a role [11,22,23].…”

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

“…Other theories highlight the fact that the gastrointestinal tract is the region of entry of many substances that may be implicated to psychiatric pathology [19]. Furthermore, the ingestion and breakdown of gluten into immunogenic peptides leaking through the intestinal wall and getting into the brain may potentially interfere with its functioning [12,13,[19][20][21]24].…”

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

“…Psychiatric disorders often reported in the literature include autistic spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder, depression, anxiety, schizophrenia, other psychotic disorders and eating disorders [1,7,8,[10][11][12][13][14][15]. These psychiatric disorders are therefore the focus of this systematic review and meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

2020

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Background: Coeliac disease (CD) is increasingly prevalent and is associated with both gastrointestinal (GI) and extra-intestinal manifestations. Psychiatric disorders are amongst extra-intestinal manifestations proposed. The relationship between CD and such psychiatric disorders is not well recognised or understood. Aim: The aim of this systematic review and meta-analysis was to provide a greater understanding of the existing evidence and theories surrounding psychiatric manifestations of CD. Methodology: An online literature search using PubMed was conducted, the prevalence data for both CD and psychiatric disorders was extracted from eligible articles. Meta analyses on odds ratios were also performed. Results: A total of 37 articles were included in this review. A significant increase in risk was detected for autistic spectrum disorder (OR 1.53, 95% CI 1.24–1.88, p < 0.0001), attention deficit hyperactivity disorder (OR 1.39, 95% CI 1.18–1.63, p < 0.0001), depression (OR 2.17, 95% CI 2.17–11.15, p < 0.0001), anxiety (OR 6.03, 95% CI 2.22–16.35, p < 0.0001), and eating disorders (OR 1.62, 95% CI 1.37–1.91, p < 0.00001) amongst the CD population compared to healthy controls. No significant differences were found for bipolar disorder (OR 2.35, 95% CI 2.29–19.21, p = 0.43) or schizophrenia (OR 0.46, 95% CI 0.02–10.18, p = 0.62). Conclusion: CD is associated with an increased risk of depression, anxiety, eating disorders as well as ASD and ADHD. More research is required to investigate specific biological explanations as well as any effect of gluten free diet.

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“…A complex interaction between CD and such psychiatric disorders is proposed in the literature [10,12,15,16]. Theories are often split into specific and non-specific mechanisms [16].…”

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

Section: Interaction Between CD and Psychiatric Disordersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

2020

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Review article: Systemic consequences of coeliac disease

Laurikka

Kivelä

Kurppa

et al. 2022

Aliment Pharmacol Ther

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Epidemiology and risk of psychiatric disorders among patients with celiac disease: A population‐based national study

Alkhayyat

Qapaja

Aggarwal

et al. 2021

J of Gastro and Hepatol

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Background and Aim: Celiac disease (CD) is a chronic disorder resulting from an immune reaction to gluten in genetically predisposed individuals. Although several studies have linked CD to psychiatric diseases, there are limited data on this topic. Using a large database, we sought to describe the epidemiology of several psychiatric disorders in CD. Methods: We queried a multicenter database (Explorys Inc), an aggregate of electronic health record data from 26 major integrated healthcare systems from 2016 to 2020 consisting of 360 hospitals in the USA. A cohort of patients with a Systematized Nomenclature Of Medicine -Clinical Terms diagnosis of CD was identified. Multivariate analysis was performed using Statistical Package for Social Sciences version 25. Results: Of the 37 465 810 patients in the database between 2016 and 2020, there were 112 340 (0.30%) individuals with CD. When compared with patients with no history of CD, patients with CD were more likely to have a history of anxiety (odds ratio [OR]:

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The relationship between mucosal damage in celiac disease and the risk of neurological and psychiatric conditions is much more complex than previously thought

Abstract: Click http://onlinelibrary.wiley.com/doi/10.1111/ene.13564/abstract to view the accompanying paper in this volume.

Cited by 7 publications

References 11 publications

Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

Review article: Systemic consequences of coeliac disease

Epidemiology and risk of psychiatric disorders among patients with celiac disease: A population‐based national study

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