The relationship between neonatal factors and involving with glucose-6-phosphate dehydrogenase deficiency (G6PD) and patients' outcome in Fars Province

Abstract

Introduction: Glucose-6-phosphate dehydrogenase deficiency (G6PD) or fauvism is the most common enzyme deficiency in human, so that 400 million people are living with this disease worldwide. This study aimed to investigate the role of some neonatal factors among newborns suffering from G6PD deficiency and neonatal outcomes associated with this disease. Materials and methods: In this study, two methods including case-control and retrospective cohort regarding some neonatal factors associated with G6PD deficiency were used. These methods were performed on 142 children with this kind of deficiency and 142 healthy infants in the city of Marvdasht during 2013-2014. The analysis of data was based on chi-square tests, t-test, logistic regression, descriptive statistics and estimation of odds ratios or relative risks via SPSS16 software. Results: Totally 284 newborns including 132 (46.6%)/ 152 (53.4%) boys/girls and mean weight on birth of 3163 ± 471 (gr) were analyzed. Comparison of case and control samples did not show any significant differences between sex and involving with G6PD deficiency but the chance of having a baby with this defect in pregnancy intervals between 6 to 8 years was increased (95% CI: 1-4.4, OR: 2). Relative risk of jaundice in infected and healthy infants was estimated as 3.73, which demonstrated a statistically significant association (95% CI: 1.33-10.4). Conclusion:The results of this study showed that the number of hospitalization is increased due to jaundice in infants with G6PD. There is also an insignificant relation between low birth weight, rank of birth and type of delivery.

Glucose-6-Phosphate Dehydrogenase Deficiency among Newborns in Sana’a City, Yemen

“…The lack of significant association between the mode of delivery of the newborns and G6PD deficiency in the present study is in line with those reported from Fars, Iran [40] and Egypt [41], while the lack of significant association of G6PD deficiency among newborns and prematurity is consistent with findings from Fars and Isfahan in Iran [40,42] and India [43]. Some studies suggest that premature infants can even have a higher G6PD activity compared to near term infants, and prematurity does not interfere with the diagnosis of G6PD deficiency [44,45].…”

Newborn screening and diagnosis for Glucose-6-phosphate dehydrogenase deficiency at Danang Hospital for Women and Children

“…Trong khi đó, không có sự khác biệt có ý nghĩa thống kê khi khảo sát theo các đặc điểm tiền sử gia đình, tuổi thai khi sinh, trọng lượng khi sinh, thiếu máu. Nghiên cứu của Daliri ở Iran cũng cho thấy mối liên quan của thiếu enzyme G6PD với vàng da, nhưng không liên quan với tuổi thai khi sinh, trọng lượng khi sinh [16]. Nghiên cứu của chúng tôi ghi nhận có 82,98% trẻ thiếu enzyme G6PD có vàng da.…”